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Viral Replication and Genome Characteristics, Quizzes of Physiology

Indiana University Bloomington (IU)Physiology

Definitions and terms related to viral replication, genome possibilities for viruses, and viral structures. Topics include icosahedral and helical capsids, viral attachment, diassembly, replication, assembly, burst size, viral eclipse, and viral replication mechanisms for both dna and rna viruses. Also discussed are genetic variations due to viruses and mechanisms of viral infection and immune response.

Typology: Quizzes

2011/2012

Uploaded on 08/17/2012

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TERM 1
Genome possibilities for virus
DEFINITION 1
DNA: ss or ds, linear or circularRNA:1. positive sense2.
negative sense3. double stranded positive sense4 double
stranded negative sense5. ambisense
TERM 2
icosahedral capsid
DEFINITION 2
polygon with 12 vertices and 20 symmetric facets
TERM 3
helical capsid
DEFINITION 3
easier to destroyrepeating single polypeptides with h-
bonding to each other.
TERM 4
viral attachment
DEFINITION 4
virus attaches self to host cell
TERM 5
viral diassembly
DEFINITION 5
the viruses are being broken down
pf3
pf4
pf5

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Genome possibilities for virus

DNA: ss or ds, linear or circularRNA:1. positive sense2.

negative sense3. double stranded positive sense4 double

stranded negative sense5. ambisense

TERM 2

icosahedral capsid

DEFINITION 2

polygon with 12 vertices and 20 symmetric facets

TERM 3

helical capsid

DEFINITION 3

easier to destroyrepeating single polypeptides with h-

bonding to each other.

TERM 4

viral attachment

DEFINITION 4

virus attaches self to host cell

TERM 5

viral diassembly

DEFINITION 5

the viruses are being broken down

viral replication

the replication of the viral genome and proteins

TERM 7

viral assembly

DEFINITION 7

the increase in # of virons

TERM 8

burst size

DEFINITION 8

final titer- initial titernet gain

TERM 9

viral eclipse

DEFINITION 9

nucleic acid is uncoated, infectious virus particles can't be

recovered from the cell.

TERM 10

viral replication; attachment

DEFINITION 10

passive absorption due to the interactions between the host

cell glycoproteins and the virus (naked=capsid proteins,

enveloped=glycoproteins)

RNA virus replication

replicate in cytoplasm; exception, influenza and

retroviruses.

viruses genome replication require

RNA-dependent RNAP; exception,

retroviruses.

TERM 17

+ssRNA viruses, viral genome

DEFINITION 17

mRNA

TERM 18

for ssRNA or dsRNA viruses how is mRNA

synthesized?

DEFINITION 18

virion-associated RNA-dependent RNAP

TERM 19

what is an inclusion body

DEFINITION 19

virus in duced chane in the host cell membrane or

chromosomal structure

TERM 20

why are inclusion used as a diagnostic

test

DEFINITION 20

nature and location are characteristic of particular viral

infection

mechanisms of genetic variation due to

viruses

mutation resulted from error-prone viral

polymerasessgenetic exchanges between viruses and host

genomes-> cause a new strain of virus

TERM 22

recombination def.

DEFINITION 22

Intramolecular or intermolecular genetic exchange between

related viruses or the virus and the host.

TERM 23

reassortment def.

DEFINITION 23

coinfection with viruses of segmented genomes from

different species

TERM 24

phenotypic mixing def.

DEFINITION 24

coinfection of two phenotypes, transcapsidation takes place

and pseudotypes of virions can arise

TERM 25

marker rescue/ complementation def.

DEFINITION 25

a defective viral strain (lethal or conditional) rescued by a

replacement gene offered from host or other sources.

latent infection

def.

caused by DNA viruses or retrovirusesinfection can be

reactivated.