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Uric acid is a byproduct of purines (PYUR-eenz). Purines are naturally occurring substances and are found in many food items. As purines are broken down in the body, they are eliminated as uric acid.
Normally, uric acid passes through the kidneys and is excreted in urine. However, when the kidneys cannot process all of the uric acid, hyperuricemia , or elevated uric acid in the blood, may develop. This can lead to development of uric acid crystals in joints and tissues causing a type of arthritis known as gout. Gout or gouty arthritis, occurs when these uric acid crystals build up in your joints, particularly in the big toes or ankles. This can cause acute pain, tenderness, swelling and redness. If left untreated, it can structurally damage the joints.
Recent research has determined that approximately 10% of Americans with Chronic Kidney Disease (CKD) also have gout (or hyperuricemia), and if left untreated, can further worsen kidney function, (1). In addition to decreasing foods high in uric acid from your diet, your healthcare provider may also prescribe medications to reduce the uric acid in the blood as well.
When your kidneys are not functioning properly, they do not filter out uric acid properly, thus potentially leading to a number of health issues.
Elevated hyperuricemia (elevated uric acid levels) may cause;