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MCCQE- batch 1 2026
If a new born has not passed Meconium within the first 48hours after birth, what does it suggest? Congenital Aganglionic megacolon (Hirschsprung disease) Initial steps for unexplained ventricular premature beats 24hour ambulatory (Holter Monitor) First Line for Panic Attacks? SSRIs Screening for Antiphospholipids syndrome? Lupus anticoagulant How to confirm a hyperfunctioning Thyroid nodule? Thyroid uptake & scan Most Appropriate management of neurological deficit from spinal cord compression in malignancy? Emergent Glucocorticoids ( IV Dexamethasone therapy) Most common cause of Infectious Epididymitis in sexually active postpubertal men < Chlamydia & Gonorrhoea 1st Line Treatment of Gastroparesis? Metoclopramide (lowest effective dose) tetrad of henoch schonlein purpura palpable purpura , arthritis/arthralgia, abdominal pain, and renal involvement(hematuria) Treatment of Endometrial hyperplasia without atypia Progestin therapy Immediate control of hyperthyriodism symptoms beta blockers(propanolol) What is Hamman's sign and what could it indicate? crunching, rasping sound, synchronous with the heartbeat,heard over the precordium,could be seen in bronchial rupture
Treatment of early localized lyme disease Doxycycline, Amoxicillin and Cefuroxim axetil. avoid doxycycline in children<8 and pregnant women. Symptoms and treatment of Wilsons disease? "Symptoms: Jaundice, tremors, stiffness, speech/coordination issues,depression, mood swings, and characteristic brownish Kayser-Fleischer rings in the eyes; treatment : chelators like penicillamine/trientine or zinc" Symptoms and management of ethylene glycol poisoning? "Presentation: dizziness, nausea, vomiting, slurred speech, flank pain, oliguria, seizures, coma due to calcium oxalate crystals(detectable in urine); management - fomepizole or ethanol" Drug of choice in Narcolepsy Modafinil 1st line therapy for patients with urinary stones in mid or distal ureter >10mm "uterorenoscopy (esp in morbidly obese) second line: Shockwave Lithotripsy " What is acalculous cholecystitis? severe gallbladder inflammation without gallstones, typically striking critically ill patients due to factors like prolonged fasting, trauma, or sepsis, causing gallbladder stasis, ischemia, and potential gangrene or perforation, with symptoms like RUQ pain, fever, nausea Symptoms and First line for acute hapatic encephalopathy? "Symptoms; Confusion, Irritability management: Lactulose" What causes increased risk of calcium oxalate nephrolithiasis in crohns? Malabsorption of Fatty acids. Most common complication of Kawasaki? Coronary artery aneurysm. Signs & Symptoms of Kawasaki?
Treatment of Alzheimers "Mild to moderate- acetylcholinesterase inhibitors (Donopezil), Moderate to severe (<18/30 MMSE) - NMDA receptor antagonist (Memantine)" What is the treatment of choice in stable women with acute uterine bleeding? High-dose Oral conjugated estrogen First line treatment for prolactinomas Dopamine receptor agonists such as Cabergolin or Bromocriptine. Preferred initial test in patients with high pretest probality of DVT Compression Ultrasonography First Line for restless leg syndrome Dopamine agonist like Ropinirole Recommended Contraceptive in Breastfeeding women Progestin-only pills (mini pill) First line management of patients with dermatitis herpetiform and celiac disease Oral Dapsone Symptoms of Fibromuscular dysplasia "High blood pressure, kidney function issues. Headaches, dizziness, tinnitus, stroke, vision changes." What investigation confirms diagnosis of Fibromuscular dysplasia CT angiography (strings of beads appearance of renal artery) Most common complication of caustic liquid ingestion esopahgeal strictures treatment of varicocele surgery (microsurgical varicocelectomy, laparoscopic) or embolization Cause of indirect inguinal hernia failure of processus vaginalis closure First line treatment for trigeminal neuralgia & Epilepsy Carbamazepine
Treatment of acute Bacterial Rhinosinusitis (>10days) Oral Amoxicillin-clavulanate 1st line surgical procedure for stress incontinence Urethral sling Osgood schlatter disease-symptoms & management Osgood-Schlatter Disease causes pain, swelling, and a tender bump below the kneecap in growing adolescents, especially athletes, due to repetitive stress on the patellar tendon insertion. Management focuses on rest, ice, activity modification, pain relievers (ibuprofen/acetaminophen), stretching tight leg muscles (quads/hamstrings), and strengthening exercises, with most cases resolving as the child stops growing. Formular for Relative risk a/(a+b) / c/(c+d) Formular for Negative predictive Value TN/(TN + FN) x 100% Formular for Positive predictive Value TP / (TP + FP) x 100% formular for Specificity TN / (TN + FP) formular for sensitivity TP / (TP + FN) formular for Attack Rate: Total new cases / Total population Formular for Attributable risk (Also known as ; ARI) a/(a+b) - c/(c+d) Formular for Attributable risk percent (Risk in Exposed - Risk in Unexposed) / Risk in Exposed * 100% formular for number needed to treat NNT = 1 / ARR formular for number needed to harm
serum transferrin saturation. management for organophosphate poisoning artropine & pralidoxime What are the most common tool for assessing stroke patients Rankin scale & Barthel index What is the treatment for nerve gas (sarin) poisoning? Atropine What is the preferred treatment of mania or hypomania in patients with bipolar disorder? Valproic acid What is reaction formation? It is converting unacceptable impulses into their opposite What medication can be used for management of conduct disorder in children? Risperidone, an atypical antipsychotic, is effective in reducing aggression and irritability in children with conduct disorder and other behavioural issues. What are the side effects of quetiapine? "Quetiapine is an antipsychotic medication that can cause sedation and impair motor coordination, increasing the risk of falls, especially in older patients (≥ 65 years) with cognitive impairment. " What are the side effects of Risperidone? (Gyne) Anti-pyschotic induced hyperprolactinemia (amenorrhea, infertility, sexual dysfunction, galactorhea, weight gain). Tetrad of neuroleptic malignant syndrome Hyperthermia, Muscle rigidity, mental status change, autonomic disability ( tachycardia, high blood pressure, tachypnea) What Chemoprophylaxis is used for patients (close contacts) exposed to meningococcal disease? Rifampin, Ciprofloxacin, and Ceftriaxone, Prophylactic treatment for eosophageal varices Beta-adrenegic blockers (propanolol, nadolol)
How is Diagnosis of tinea versicolor made? Potassium hydroxide (KOH) preparation of skin scraping shows curved hyphae and round yeast cells appearing as spagetti and meatballs. What is the treatment for tinea versicolor? "Topical Terbinafine, Ketoconazole, Selinium sulfide widespread, Recurrent, resistant to treatment : Oral Ketoconazole, fluconazole:" What is the treatment for cellulitis? "Non-purulent : cephalexin (Keflex) or dicloxacillin Purulent : clindamycin (Cleocin) or trimethoprim-sulfamethoxazole (Bactrim)" What is the most sensitive imaging modality in patients with foot osteomyelitis? MRI of the foot What is the best diagnostic test for superior vena cava syndrome Contrast CT scan of chest and neck What are the symptoms of superior vena cava syndrome? (secondary to lung malignancy) dyspnea, persistent cough, facial swelling, neck pain, hoarness of voice, dysphagia Most common cause of infective endocarditis following dental procedures? Strepococcus viridans group esp S. mutans Management of serotonin syndrome "Mild- Supportive Moderate - Cyproheptadine (5-HT2A agonist) Severe- ICU, intubation, Sedation, aggressive cooling" Management of Alcohol induced psychosis (due to intoxication) Mechanical restraints & Haloperidol Meaning of the Acronym SIGECAPS for depression Sleep, interest, guilt, Energy, concentration, Apetitie, psychomotor, suicide Management of hypomanic to mild-moderate manic episodes Monotherapy with risperidone or olanzapine Treatment of severe mania
fatigue, weakness, pancytopenia (aneamia, thrombocytopenia, neutropenia), ovalmicrocytosis, basophilic stippling and reticulocytosis on peripheral blood smear How do you confirm diagnosis of Myelodisplastic syndrome Bone marrow biopsy What type of collagen is affected in osteogenesis Imperfecta? Type 1 collagen (COL1A1) What drug is used in the treatment of open angle glaucoma Timolol CSF in Guillian barre syndrome shows? high protein levels with a normal white blood cell count groove sign is seen in what std presentation lymphogranuloma venereum (chlamydia trachomatis) signs of Metrothrexate toxicity stomatitis, G.I disturbances, fever, macular rash, megaloblastic anemia prevention of Metrothrexate toxicity folic acid
