Microbiology and Immunity notes, Lecture notes of Biology

A few notes on the basics of microbiology and immunity

Typology: Lecture notes

2018/2019

Uploaded on 04/11/2019

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MICROBIOLOGY AND INMUNITY.
Handy definitions.
Microbe (com.name)/microorganisms organisms that you can see with a microscope.
Pathogen is a microbe that causes disease.
Immunity the ability to stop getting ill/infected.
Lymph defensive fluid.
Commensal bacteria bacteria that that live inside/on you and don’t cause you any harm.
Pathogenic bacteria bacteria that DO cause harm.
Virus not alive; can cause disease.
Pathogen microorganism that causes disease (including viruses).
1. The immune system and non-specific defences.
The immune system can be characterised as being made up of
different lines of defence. The first two lines are non-specific; the
third one is specific.
1.1. The first line of defence.
The first line of defence of the immune system is a collection of defences. They
prevent pathogens from entering the body or persisting in/on it.
1.2. The second line of defence.
The second line of defence consists of blood clotting, inflammation, wound repair and
phagocytosis.
1.1. Blood Clotting.
What are 4 things needed for clotting to occur?
Platelets, clotting factors, fibrin and other cells (red, white cells)
What are the 4 stages in the clotting process?
Firstly, the nearby platelets become sticky and stick together to create a plug.
Secondly, clotting factors add themselves to the plug to make it stronger. Thirdly,
fibrin acts as glue, holding everything together. Finally, other cells usually get caught
in the glue making the clot stronger.
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MICROBIOLOGY AND INMUNITY.

  • Handy definitions.

Microbe (com.name)/microorganisms organisms that you can see with a microscope.

Pathogen is a microbe that causes disease.

Immunity the ability to stop getting ill/infected.

Lymph defensive fluid.

Commensal bacteria bacteria that that live inside/on you and don’t cause you any harm.

Pathogenic bacteria bacteria that DO cause harm.

Virus not alive; can cause disease.

Pathogen microorganism that causes disease (including viruses).

1. The immune system and non-specific defences.

The immune system can be characterised as being made up of

different lines of defence. The first two lines are non-specific; the

third one is specific.

1.1. The first line of defence.

The first line of defence of the immune system is a collection of defences. They

prevent pathogens from entering the body or persisting in/on it.

1.2. The second line of defence.

The second line of defence consists of blood clotting, inflammation, wound repair and

phagocytosis.

1.1. Blood Clotting.

  • What are 4 things needed for clotting to occur? Platelets, clotting factors, fibrin and other cells (red, white cells)
  • What are the 4 stages in the clotting process? Firstly, the nearby platelets become sticky and stick together to create a plug. Secondly, clotting factors add themselves to the plug to make it stronger. Thirdly, fibrin acts as glue, holding everything together. Finally, other cells usually get caught in the glue making the clot stronger.
  • How is the clot removed by the body when no longer needed? Your body dissolves it.

1.2. Inflammation.

Inflammation is the generic term given to the physiological response to tissue damage or infection. It is characterised by swelling, heat, pain, redness and loss of function. It is complex.

1.3. Wound repair.

At the scab, stem cells divide by mitosis and platelets secrete growth factors.

New blood vessels collagen granulation tissue to fill the wound new epithelial cells death of unwanted cells

1.4. Phagocytosis.

Phagocytes are a kind of white blood cells. Different kinds of phagocytes are found in different parts of the body.

  • Neutrophils: They circulate in blood; they have a rapid response and they are short lived (pus)
  • (^) Monocytes: They leave the bloodstream and they differentiate into macrophages; they process and present antigens, some migrate, and some are stationary (spleen, lymph)
  • Dendritic cells: they have a large surface area and they passage infected and foreign materials to lymph nodes.
  • Macrophages: they are found throughout the body, waiting to attack invaders.

Every cell in the body have antigens, and they are ‘markers’ that identify the cell/toxin/ substance and if the antigens do not match that of yourself, they are identified as antigens and they will be chased and eaten by macrophages.

2. The immune system and specific defences.

Phagocytes once they have eaten antigens, they show it to T cells (cell-

mediated response) which then differentiate into many cells, one of them, Cell T Helper which pass the message to B cells that now will have receptors for the antigen that had been