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NR565 Week 2 Study Guide
Chapter 1: The Role of the Nurse Practitioner as Prescriber Roles and Responsibilities of APRN Prescribers APRN prescriber is responsible for the final decision on which drug to use and how to use it. Degree of autonomy in this role and the breadth of drugs that can be prescribed vary from state to state based on the nurse practice act of that state. Nurse practitioner prescriptive authority is regulated by the State Board of Nursing for each state. Advanced Knowledge o Additional knowledge, critical thinking, and assumption of a higher level of legal responsibility are required to assume the prescriber role o Knowledge of medicine, pharmacology, and nursing intertwine in the NP role o As a prescriber, it becomes the role and responsibility of the NP to determine the diagnosis for which the drug will be ordered, prescribe the appropriate drug, monitor the expected outcome of the drug, and incorporate a holistic assessment of the impact of disease and therapy on patient lives Benefits of an APRN as Prescriber o Alternative treatment options are also part of the armamentarium that can be used to treat a given disorder and may interact with the pharmacotherapeutic intervention o APRN look at the big picture and consider alternative treatment options and lifestyle changes o Patients are looked at in a holistic approach and include the patient in decision making regarding their care. o NP practice may thrive under healthcare reform because of the demonstrated ability of nurse practitioners to control costs and improve patient outcomes Clinical Judgment in Prescribing Prescribing drug results from: o Clinical judgment based on a thorough assessment of the patient and the patient's environment o Determination of medical and nursing diagnoses o A review of potential alternative therapies, and specific knowledge about the drug chosen and the disease process it is designed to treat o NPs factoring in the cost to the patient of the medication prescribed Is there a clear indication for drug therapy? o In the age of health-care reform and increased awareness of the limitations of drugs, whether a medication is the best option for treatment has become an important question. What drugs are effective in treating this disorder? o Several drugs may be effective in treating a condition, so which one is best for a particular patient? Even if only the most effective class of drug is considered, few classes of drugs include only one drug o How does one determine “best”; what are the criteria? Are there nationally recognized guidelines that can be used? The Agency for Health Care Quality (AHCQ), the National Institutes of Health (NIH), and many specialty organizations publish disease-specific treatment guidelines that include both pharmacological and nonpharmacological therapies Consult nationally recognized guidelines for disease management
What is the goal of therapy with this drug? o What is the best drug to achieve treatment goals? Various goals are possible in the choosing of therapy Under what conditions is it determined that a drug is not meeting the goal and a different therapy or drug should be tried? o At the onset of therapy, the provider and patient should have a clear understanding of what outcome or goal is expected of the medication prescribed o Follow-up and monitoring times are established to see how well treatment with the drug is meeting the goal Are there unnecessary duplications with other drugs that the patient is already taking? o The patient’s medication history should be reviewed at each encounter to detect duplications or medications that may be discontinued Would an OTC drug can be just as useful as a prescription drug? o Increasing numbers of drugs are being moved from prescription to over-the-counter (OTC) status What about cost? o Who will pay for this drug? Can the patient afford it? Will the cost of the medication affect adherence to the treatment regimen? Cost is an issue for several reasons Many insurance policies do not cover the cost of drugs or only provide partial coverage, so the patient must pay “out of pocket” The newer the drug, the more likely the cost is too high based on the drug manufacturer’s need to reclaim research and development costs while the corporation still holds the patent on that drug Newest is not always best, and condition of cost is a major factor in choosing between newer drugs and ones that have been around long enough to be available in generic form Many insurance plans have larger copays for name-brand drugs than for generic medications Multiple national retail pharmacies have developed $4 prescription formularies Awareness of what is on the local discount formulary may save the patient hundreds of dollars in prescription costs and may increase compliance Factors likely to lead to poor adherence include a drug that is expensive in relation to a patient's finances, a drug that must be taken daily as part of a complex regimen, and a drug that is not covered by insurance. Where is the information to answer these questions? o Wide array of professional literature that ranges from the well-reputed journals to literature from specialty and professional organizations, the multitude of computerized drug databases Collaboration with Other Providers Collaborate with physicians, pharmacists, podiatrists, mental health specialists, therapists, and other providers, including APRNs who are not NPs, physician assistants (PAs), and other nurses. Physicians o Early in the development of the NP role, physicians were the teachers in the NP programs and accepted NPs as physician-extenders Pharmacists o Profession of pharmacy requires graduate-level preparation for all pharmacists with the granting of a practice doctorate, the Doctor of Pharmacy (PharmD) o A PharmD can assist by offering expertise on the clinical management of patients, including available dosage forms, potential adverse reactions, and drug interactions Other APRNs
of compounds-- animals, isolated cell cultures and tissues, enzymes, and cloned receptor sites, as well as computer models o Pharmaceutical dosage formulation and stability testing make up the process of turning an active compound into a form and strength suitable for human use o Toxicology and safety testing determines the potential risk a compound poses to people and the environment Stage Two: Clinical Investigation o Investigational new drug (IND) application is filed with the FDA prior to human testing of any new drug entity--description of the clinical research plan -- clinical tests can begin 30 calendar days after submission Phase 1: Establishing the tolerance of healthy human subjects at different doses; defining its pharmacological effects (absorption, distribution, metabolism, and excretion). Phase II: Target disease or disorder to determine a compound's potential --small number of patients. Phase III: Trials are controlled and uncontrolled clinical trials of a drug's safety and efficacy in hospital and outpatient settings--drug's efficacy for specific indications-- broader range of adverse effects --best way of administering and using the drug for the purpose intended.--verify that the acceptable risk/benefit ratio seen in phase II persists under--must report in writing to the FDA within 10 working days any serious and unexpected adverse reactions. Stage Three: NDA Review o To market a new drug for human use, a manufacturer must have a new drug application (NDA) approved by the FDA o All information about the drug gathered during the drug discovery and development process is assembled in the NDA o During the review period, the FDA may ask the company for additional information about the product or seek clarification of the data contained in the application o The FDA has 60 days to determine whether the NDA will be filed for review o Once filed, a team reviews the drug sponsor’s research on safety and effectiveness of the drug o Usually, the FDA requests additional information, and the manufacturer needs from 1-5 years to complete any additional well-controlled trials necessary to support the claimed indications or prove the drug’s safety Stage Four: Postmarketing Research o In order to detect rare adverse drug reactions, hundreds of thousands of patients have to have taken the drug. Clinical trials conducted after a drug is marketed are an important source of information for postmarketing evaluation o Regulatory authorities can require companies to conduct phase IV studies as a condition of market approval o An important source of postapproval information is data collected and submitted by practitioners in the field through programs such as MedWatch U.S. FDA Regulatory Jurisdiction Official Labeling o The legal distinction between a legend drug and an over-the-counter (OTC) drug is not founded on relative safety per se but rather involves a regulatory decision on whether adequate directions for the drug's proper use can be written for the layperson o The FDA is concerned with the marketing and availability of drugs that have demonstrated substantial evidence of an acceptable risk/benefit ratio for labeled indications o The proper and efficacious therapeutic use of these drugs is the responsibility of the prescriber
o FDA regulates the official labeling for all prescription and OTC drugs Off-Label Use of Drugs o Use of an FDA-approved drug in a dose or route for which it was not approved or for a clinical indication other than the FDA-approved use o Nurse practitioners (NPs) are responsible for knowing the FDA indication and approval status of any drug they prescribe o Prescribing is legal if there is scientific evidence for the use Controlled Substance Laws o The most comprehensive federal drug legislation is the Controlled Substances Act of 1970 o Every person who manufactures, distributes, prescribes, procures, or dispenses any controlled substance must register and obtain a registration number with the U.S. Drug Enforcement Administration (DEA) o NPs wanting authority to prescribe controlled substances must apply for state prescriptive authority prior to application for a federal DEA number o National Provider Identifier number (NPI) The NP should obtain an NPI as soon as it is feasible NPs must know the different classifications and schedules of controlled drugs as well as the associated prescribing rules and regulations Controlled Substance Prescribing Precautions o Some states, NP's license number appear on the prescription in addition to that of any supervising/collaborating practitioner o DEA registration number must be designated on all controlled substance prescriptions o DEA registers manufacturers and prescribers of controlled substances o Prescription should be dated on the day it is written, indicating any authorized refills as allowed and clinically appropriate o As of 2009, tamper-proof prescription pads are required for prescriptions written for patients under Medicaid payment plans Controlled Drug DEA Schedules (Table 4-1) Schedule Controls Required Drug Examples I No accepted medical use No legal use permitted For registered research facilities only Heroin, LSD, mescaline, peyote, marijuana* II No refills permitted No telephone orders unless true emergency and followed up by written prescription within 7 days Electronic prescribing permitted as of 2011 with specific software and secure identification processes Narcotics (morphine, codeine, meperidine, opium, hydromorphone, oxycodone, oxymorphone, methadone, fentanyl) Stimulants (cocaine, amphetamine, methylphenidate) Depressants (pentobarbital, secobarbital)
Pressure to Prescribe o Another factor that increases the demand for controlled substances is the pressure to prescribe at every visit and the expectation that patients deserve a prescription for something at each visit or for each symptom offered o This process results in two well-known adverse situations Overprescribing of antibiotics and resulting antibiotic resistance Polypharmacy Complaints Enabling o The powerful instinct in practitioners to do anything medically possible to enable patients with present or potential disability to live at a higher level of function When You Suspect a Patient is Misusing Medications Communication Barriers o Clinical interview and practitioner–patient relationship-building skills Skill building involves active learning strategies in the areas of verbal and nonverbal communication, empathy, and rapport building Communication Skills One strategy is to just say no and mean it. By making the statement “I am feeling pressured by you to write a prescription today that is not clinically indicated. Because of this I am really concerned about you, and we need to talk about your use of alcohol or other substances,” the NP can often effectively turn the tables and shift the discomfort to the patient while still refusing to prescribe Systemic Solutions to Problems of Controlled Substance Prescribing o Careful charting and documentation habits are essential for prescribing controlled drugs Document clearly in a progress note Physical evaluation of the patient The diagnosis The clinical indications for treatment The written treatment plan The expected symptom outcomes Informed consent and agreement for treatment from the patient Consultation and/or collaboration necessary to meet treatment goals and objectives These strategies reduce, but do not eliminate, the risk of controlled drug diversion from one's practice Prescribing Tips o A few tips can help the practitioner reduce environmental facilitation of prescription misuse Collect and document a complete history and examination before prescribing controlled substances Do not rely on patient-supplied history, xrays, or medical records to confirm your assessment—obtain this information directly from the primary source Passik and Weinreb (2000) advise use of the four “A’s” to guide initial and ongoing assessment of medication efficacy o Analgesia measurement by use of pain scales or other assessment tools o Activities of daily living (ADLs) as measured by levels of physical and psychological functioning o Adverse effects
o Abuse issues Prescribe limited quantities without refills on a first visit, allowing additional time for patient assessment and confirmatory documentation Educate medical and assistive staff in reinforcement of consistent clinic policies and procedures related to scheduling, forms, urine drug screening, records view and release, and refills It is not uncommon for patients who do misuse substances to quickly identify the “weak link” among the treatment team and focus their energies on this person or process Standardize expectations regarding after-hours calls, use of multiple providers, and weekend or early refills and post them where they are readily available Patients covered by insurance plans, including Medicaid and Medicare, can be limited to one pharmacy or one prescriber through their payment plan Case managers can often be utilized to help review and manage medication use and advocate for access to additional options for pain management and control Other tips Prescribing generic, longer-acting formulations of drugs that have less stress value Writing out the quantity prescribed rather than using only numerals, which can be altered Use tamper-proof paper for all prescriptions written for controlled drugs Medication Agreements/”Pain Medication Contracts” o Defining and implementing treatment objectives is the medication agreement This written tool can be incorporated into treatment of chronic pain, particularly if long- term management with opioids is indicated o NPs are advised to familiarize themselves with urine drug and alcohol screens and their availability, cost, sensitivity, and specificity o In-office rapid screenings are now available that can be done quickly and without prior notice in order to confirm adherence to medication agreement criteria o Contract used universally for all prescribing for chronic pain Prescription Drug Monitoring Programs o As of 2012, all but one state (Missouri) have an active or legislatively enabled Prescription Drug Monitoring Program (PDMP) o A PDMP enables practitioners to query a confidential database of controlled substances statewide to evaluate State Law o Authority to prescribe is a function of state law o Prescriptive authority varies from state to state o A license is always required for practice as an NP o The state Nurse Practice Act specifies the exact title that must be used for practice and on a prescription o Independent authority permits the prescriber to exert autonomous judgment o Dependent authority exists when the primary prescriber delegates the authority to another through a collaborative or supervisory agreement status of prescribing in each state Writing and Transmitting the Prescription o Use preprinted prescription pads/electronic templates that contain the name, address, and telephone number and NPI number of the prescriber o This will allow the pharmacist to contact the prescriber if there are any questions about the prescription Designate the complete drug name, strength, dosage, and form
o May sell supplements –vitamins Chapter 13: Over-the-Counter Medications OTC Medication Characteristics and Regulation Characteristics o Must be safe o Has low potential for misuse or abuse o Can be labeled o Patient must be able to self-diagnose the condition for which the drug is being taken o Must be for a condition that the patient can manage without supervision by a licensed health professional Regulation o FDA Center for Drug Evaluation and Research (CDER) is responsible for ensuring that OTC drugs are properly labeled and that their benefits outweigh their risks o New OTC drug ingredients must undergo the New Drug Application process, just like prescription drugs OTC Medication Sales The Consumer Healthcare Products Association (CHPA) o $33.1 billion in 2013 in sales of OTC medications o Proposes that every dollar spent on OTC medications by consumers saves the U.S. healthcare system $6-$7, based on cost savings in clinical visits and drugs Pharmaceutical companies may apply for the drug to change to OTC status in order to continue making large profits from their blockbuster brand-name drug Cough and colds are the ailments that generates the greatest OTC annual drug sales Hazards of OTC Self-Medication Self-Prescribing o The treatment of common health problems with medicines especially designed and labeled for use without medical supervision and approved as safe and effective for use Interactions o OTC medications may be harmful if misused or may cause harmful interactions with prescription drugs Ex: A patient may accidentally overdose on acetaminophen by taking two OTC medications that both contain acetaminophen or by taking OTC acetaminophen with prescription drugs that contain acetaminophen such as Vicodin or Percocet Adverse Effects of OTC Self-Medication Adverse Effects o All medications have predictable and unpredictable adverse effects o May be mild such as GI upset, or severe, such as GI bleeding associated with NSAID or aspirin use Treatment Duration
o Exceeding treatment duration or taking the wrong dose increases the likelihood of adverse reactions Patient Education o Patients must be educated regarding the adverse effects of OTC medications o Education includes reading the label carefully and asking questions of a pharmacist or the provider o Patients must be educated about disclosing intermittent OTC medication use as part of their drug history Drug Interactions Antacids o Consist of a metallic cation and basic ion (calcium carbonate, magnesium hydroxide), which neutralize acidity in the stomach by raising the pH o Basic property of these drugs causes them to interact with most medications by either binding with the drug molecule or altering pH and thus the absorption of drugs that need an acidic environment for optimal absorption o Most interactions can be avoided by separating the dosing of antacids by at least 2 hours from the dosing of the other oral medications Ex: tetracycline. Aluminum hydroxide and magnesium hydroxide have a strong affinity for tetracycline and form an insoluble and inactive chelate. This interaction can reduce bioavailability of tetracycline by 90% Anticholinergics o The primary adverse effects of diphenhydramine and doxylamine are anticholinergic, such as dry mouth, constipation, blurred vision, and tinnitus o Older male patients may have difficulty in urinating o Older patients may develop delirium from modest doses of diphenhydramine CNS Depressants o OTC medication taken with prescribed medication can cause additive CNS sedating effects o OTC medications that contain alcohol, antihistamines, antitussives, or antidiarrheals may all cause additive sedation when taken with CNS-sedating medications NSAIDS & ASA o The cyclooxygenase inhibitors (aspirin & NSAIDS) have a well-documented risk of GI bleeding o When combined with antiplatelet or anticoagulant medications, the risk is significantly increased and may be life-threatening o Patients who are taking antiplatelet or anticoagulant medications should be educated to not taking any OTC medication without consulting with a pharmacist or their provider Abuse of OTC Medications Combat Methamphetamine Epidemic Act o Concern over the use of OTC decongestant medications to manufacture methamphetamine has led to changes in how the drugs are sold in the U.S o The Combat Methamphetamine Epidemic Act (2006 Patriot Act) restricts the sales of all cough and cold products that contain methamphetamine precursor chemicals ephedrine, pseudoephedrine, or phenylpropanolamine o The law includes a daily and 30-day limit on retail store and internet purchases of known methamphetamine precursors o All potential precursors are to be stored behind the counter in retail stores and retailers are required to ask for ID and keep a log of who is purchasing the drugs
o Reduces fever by direct actions on the hypothalamic heat-regulating centers, which increase dissipation of body heat via vasodilation and sweating o Has advantages of minimal GI irritation and of not affecting bleeding times, uric acid levels, or respiration Pharmacokinetics After oral administration, NSAIDs are rapidly and almost completely absorbed All NSAIDs are more than 90% protein bound Widely distributed in tissues, cross the placenta, and enter breast milk in low concentrations NSAIDs are all metabolized by the liver and excreted by the kidneys, primarily as metabolites Acetaminophen is extensively metabolized by the liver and excreted by the kidneys, primarily as inactive metabolites When it is taken regularly or in large doses, the stores of one hepatic conjugate become depleted, and hepatic necrosis may occur Pharmacotherapeutics Only relative contraindications are for ketorolac, mefenamic acid, flurbiprofen, and nabumetone in the presence of preexisting renal impairment Because NSAID metabolites are excreted primarily by the kidneys, all others should be used with caution in the presence of renal function impairment The liver extensively metabolizes NSAIDs Naproxen may exhibit an increase in unbound fraction and reduced clearance of free drug in cirrhotic patients A reduced dose may be necessary Acetaminophen Poisoning o Common cause of poisoning, either intentional or accidental, due to the lay public underestimating the toxicity of the drug o A single dose of 150mg/kg of acetaminophen in children or 7.5 g to 10g in adults may be toxic o Drugs that induce CYP2E1 enzymes (carbamazepine, phenobarbital, phenytoin, isoniazid, and rifampin) or alcohol ingestion may cause hepatotoxicity when combined with acetaminophen o Stages Stage 1: 0.5-24 hours: Nausea, vomiting, diaphoresis, pallor, and anorexia. Some patients may be asymptomatic initially. Stage 2: 25-72 hours: Clinically improved; AST, ALT, bilirubin, and prothrombin levels begin to rise. Stage 3: 72-96 hours: Peak hepatotoxicity; jaundice, confusion, AST of 10, not unusual. Stage 4: 4-14 days: Death or recovery. Patients who survive enter a recovery phase. o Treatment Should be referred to a poison control center hospital If this is not possible, the following treatment regimen may be followed If the acute ingestion is more than 150mg/kg or the dose cannot be determined, obtain a serum acetaminophen assay 4 hours after ingestion If the level is more than 300mg/mL, hepatic damage has occurred in 90% of patients Minimum hepatic damage results from a level below 120mg/mL Treatment is by gastric lavage in all cases, preferably within 4 hours of ingestion Oral N-acetylcysteine is a specific antidote for acetaminophen toxicity
Contact a poison control center for correct dosing of the antidote Drug Interactions NSAIDs decrease the effectiveness of antihypertensive drugs because of their tendency to cause fluid retention and increased extracellular fluid volume Coadministraction with anticoagulants may prolong prothrombin time because both drugs affect platelet aggregation (ex. Warfarin) Drugs that have adverse reactions associated with increased risk for GI bleeding or ulcerations associated with increased risk for GI bleeding or ulceration have an even higher risk if taken with NSAIDs Drugs that require glucuronidation for metabolism may affect the metabolism of acetaminophen by competing for metabolic sites Rational Drug Selection There is no clear difference in efficacy between NSAIDs, although there may be individual differences in response The rationale for choices is provided in the Clinical Use and Dosing section below Acetaminophen is used for fever and for mild to moderate pain not associated with inflammation! Monitoring Required for long-term therapy Because NSAIDs may produce acute renal insufficiency, assess renal function (serum Cr) before initiation of therapy and annually throughout long-term therapy A CBC prior to initiation of therapy and annually is appropriate because of the risk for GI bleeding Patient Education Take the dose exactly as prescribed A missed dose should be taken as soon as the patient remembers unless it is almost time for the next dose For drugs taken more than once daily, ideally the missed dose should be taken within 1-2 hours of the time it was scheduled Doses should not be doubled Taking higher doses than prescribed dose not increase efficacy and may increase adverse reactions Patients should be informed if there is a prescribed length of time beyond which the drug may not be taken. Taking the drug with food or a full glass of fluid and remaining in an upright position for 15-30 minutes may reduce GI discomfort and adverse reactions Remind patients to avoid aspirin, alcohol, or other GI irritants while taking these drugs Patients should be aware of products that may contain acetaminophen, including cough and cold products and combination opioid products to avoid accidental overdose of acetaminophen Clinical Dosing for RA
Indomethacin SR, naproxen, and sulindac are used Naproxen and sulindac both are intermediate-acting and provide longer duration of action than indomethacin Naproxen is less likely to produce GI adverse reactions These same three drugs are used to manage the pain in gout because it is associated with inflammation. See Table 25-9 page 823. Clinical Dosing for Fever Ibuprofen is the NSAID of choice for fever in children over age 6 months and adults Acetaminophen may also be used for this purpose, but for no longer than 3 days Patients should be well hydrated if using ibuprofen for fever to decrease renal toxicity. See Table 25- page 823. Aspirin Pharmacodynamics o All salicylates have analgesic, anti-inflammatory, antipyretic, and antiplatelet actions o Salicylates lower body temperature through their effect on the hypothalamic thermostat and vasodilation of peripheral vessels, thus enhancing dissipation of heat Prostaglandin o The anti-inflammatory and analgesic activities are mediated through inhibition of prostaglandin synthesis in the same manner as NSAIDs o However, aspirin more potently inhibits prostaglandin synthesis and has greater anti- inflammatory activity than the NSAIDs o The acetyl group of the aspirin molecule is thought to be responsible for these differences COX Inhibitor o Aspirin acetylates the cyclo-oxygenase enzyme in the prostaglandin biosynthesis pathway; therefore, it may be theoretically classified as a COX inhibitor Antiplatelet o Aspirin also irreversibly inhibits platelet aggregation o Single analgesic-level doses prolong bleeding time o Acetylation of platelet cyclo-oxygenase prevents synthesis of thromboxane A, which is a potent vasoconstrictor and inducer of platelet aggregation for the life of the platelet o This drug has shown success as an antiplatelet agent for patients with thromboembolic disease Pharmacokinetics Salicylates are rapidly and completely absorbed after oral administration Bioavailability depends on the dosage form, gastric emptying time, gastric pH, presence of antacids or buffering agents, and particle size Salicylic acid is eliminated by renal excretion of salicylic acid and by oxidation and conjugation of metabolites by the liver Include H2 blockers if patient complains of heartburn to prevent GIB Pharmacotherapeutics
Taking salicylates, especially aspirin, by children or adolescents with influenza or chickenpox has been associated with the development of Reye Syndrome (vomiting, lethargy, delirium and coma) The mortality rate is 20-30%, and permanent neurological deficits have been reported in survivors Long term therapy should have CBC checked annually Hepatic Impairment o Salicylates should be used cautiously for patients with hepatic impairment o Reversible hepatic encephalopathy has occurred after even therapeutic doses for RA Renal Impairment o Cautious use is also required for patients with renal insufficiency because salicylates may cause a transient decrease in renal function and aggravate chronic kidney diseases Uric Acid Accumulation o In low doses (<2g/day), they decrease urate excretion and raise serum uric acid levels o At high doses (3-5g/day), they have a uricosuric effect; however, they are rarely tolerated at this high a dose Gout o Salicylates should be used with caution in the presence of gout ADRs o Most common adverse reaction to salicylates is GI irritation and bleeding o The amount of blood lost from GI bleeding secondary to salicylate use is usually clinically insignificant, but with prolonged use it can result in IDA o Hypersensitivity to salicylates or NSAIDs contraindicates aspirin use and requires extremely cautious use of the other salicylates o Aspirin sensitivity is more prevalent in patients with asthma, nasal polyps, or chronic urticaria o Ototoxic at increased blood levels Should be discontinued if dizziness, tinnitus, or impaired hearing develops Temporary hearing loss disappears gradually when the drug is stopped Toxicity o The acute lethal dose of salicylates in adults is 10-30g, and in children it is 3 g o Chronic salicylate toxicity can occur when more than 100mg/kg is ingested daily for 2 or more days o Signs of salicylate poisoning appear at serum levels of 30-60mg/dL o Early sign of toxicity is tinnitus o Respiratory alkalosis is seen initially o Hyperpnea and tachypnea occur as a results of increased CO2 production and a direct stimulatory effect of the salicylate on the respiratory center in the brain o Other symptoms include nausea, vomiting, hypokalemia, tinnitus, disorientation, irritability, seizures, dehydration, hyperthermia, thrombocytopenia, and other hematological disorders Treatment o Induction of emesis or gastric lavage to remove any unabsorbed drug from the stomach o Activated charcoal diminishes salicylate absorption if it is given within 2 hours of ingestion o Salicylate levels and acid-blasé, fluid, and electrolyte balances are carefully monitored o Forced alkaline diuresis by administering sodium bicarbonate increases salicylate excretion. Hemodialysis for severe poisoning Clinical Use and Dosing for Fever Aspirin is the salicylate of choice for reduction of fever in adults Contraindicated for use with pregnant patients Acetaminophen or ibuprofen are probably better for fever management in children because there is not the risk of Reye syndrome. See Table 25-12 page 832.
Periodic salicylate levels should be drawn during long-term management to check maintenance of therapeutic levels and monitor for toxic manifestations Elimination o Because all of these drugs are eliminated by the kidneys and dosage adjustments may be required based on renal function, serum Cr levels should be assessed before therapy is begun and annually throughout long-term therapy o Urinary pH should also be monitored regularly o Sudden acidification of urine can more than double the plasma salicylate level, resulting in toxicity CBC o Salicylates interfere with homeostasis o A CBC should be drawn prior to initiating therapy and at least annually throughout long-term therapy o A CBC should also be drawn and fecal occult blood studies should be done as well if there is any indication of GI bleeding Hepatic Function o Should be monitored prior to anti-rheumatic therapy and if hepatotoxicity symptoms occur o These problems are more likely in patients with rheumatic fever, juvenile RA, or preexisting hepatic diseases, especially children Ophthalmic Effects o Have been reported in patients taking diflunisal o Ophthalmic studies are appropriate for patients who develop eye complaints during therapy Patient Education Instruct the patient to take salicylates exactly as prescribed Taking with food or a full glass of water and remaining in the upright position for 15-30 minutes after administration can reduce GI irritation. Food slows absorption but does not alter the total amount absorbed Do not crush or chew enteric-coated tablets or take antacids within 1 hour of enteric-coated tablets Chewable tablets may be chewed, dissolved in liquid, or swallowed whole Instruct patients not to increase the dose beyond that prescribed Increased doses increase the risk for salicylate poisoning Most common adverse reactions are ototoxicity and GI irritation/bleeding Advise patients to report tinnitus; unusual bleeding from the gums; bruising; black tarry stools; or fever lasting longer than 3 days Patients taking salicylates should not use alcohol or other substances that increase GI irritation Parents should be informed of the risk of Reye Syndrome and educated regarding not giving aspirin to a child with a viral illness Prednisone If patient is taking 10mg daily > 6 mo, monitor for osteoporosis, especially in women If patient’s total dose will exceed 1 gram, patient will need a second prescription for omeprazole or a PPI to prevent peptic ulcer disease When discontinuing prednisone, develop a tapering schedule to slowly wean pt off medication Pt taking chronic low-dose prednisone with RA, will need co-treatment with bisphosphonate to prevent further adverse effects
Corticosteroids Patients starting chronic corticosteroid therapy will need monitoring of serum glucose Educate patients to report black tarry stools and abdominal pain Chapter 52: Pain Management: Acute and Chronic Pain Overview of Pain Concepts Pain Most common reason people seek medical attention (CDC and NIH) Expect relief when seeking treatment Brennan/Colleagues and Fishman (2007) o Pain management is a basic human right o BUT standard of care for pain management is not an absolute science or free of risk o (2011) Undertreatment for pain widely reported in the literature = Significant problem Failure to treat pain is Unethical Poor clinical practice Violation of human rights (Appropriate management) IOM- examining pain as a national health problem and transforming the understanding, prevention, assessment and treatment of pain International Association for the Study of Pain (IASP) Pain is the unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage or both PAIN IS SUBJECTIVE Suffering Emotional reaction to pain and can be manifested by feelings of helplessness or hopelessness Understanding these terms can help APN to assess pain symptoms, consider cause and develop the best pain management plan with specific presentations Acute vs Chronic Pain can be acute or chronic, generally classified by duration of symptoms and presence or absence of sympathetic nervous system activity Acute Associated with tissue injury and resolves when healing occurs. (Subcategorized: Physiological) Chronic Last more than 6 months- well beyond expected time of healing. (Subcategorized: Pathological)
