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Prescribing Basics: 2 questions Prescriptive authority regulated by the state BON in each state. Tall man lettering to highlight dissimilaries with look-alike names *Prescription contains… Physicians Name, Address, and telephone number are required to be included in the prescription. DEA number (two letters, five numbers) if the prescription is for controlled substance, Patient name and DOB (also may include address and weight), Date Rx is written (expires 1 year after date issued), Name of drug and strength- avoid trailing zeroes, use leading zeroes, Directions with indications/route of administration and frequency, write out number of refills, quantity of drug, signature, NPI number (9 or 11 numbers), sign as A-PNP or role recognized by the BON Drug schedules – one is most addictive, up to schedule 5.
- heroin, LSD, marijuana.
- oxycodone, hydrocodone, methamphetamines.
- codeine, ketamine, testosterone.
- Xanax, valium, ambien, tramadol.
- antidiarrheal, antitussives, Lomotil, lyrica. *calculation question Pharmacology Principles: 3 questions Pharmacodynamics – effect of drugs on body. Works by receptors. Usually proteins that interact with drugs. Agonist – produce receptor stimulation, conformational change every time they bind. Partial agonist – properties between agonists and antagonists. Submaximal effect. Stimulate only some of the receptors. Antagonist – affinity for receptor but NO intrinsic activity. Affinity allows antagonist to bind to receptors, but lack of intrinsic activity prevents receptor activation. Blocks action of drugs (example Narcan). Therapeutic range – between minimum effective concentration and toxic concentration. Working effectivity with no toxicity or adverse effects. Wider therapeutic range is better! Easiest to control. Bioavailability – percentage of dose of drug that survives first pass through liver and reaches blood stream. Half life – time required for amount of drug to decline by 50%. Shorter half life admin more frequently. 4.5- 5 half lives to get to steady state and to eliminate from body.
Pharmacokinetics – what body does to drug. Absorption, distribution, metabolism, elimination. (ADME) Parenteral (bypass first pass), then oral, then lungs, then skin, eye and ears for best absorption. Distribution affected by lipid/water solubility, PH, protein binding, size of molecule. Protein binding – unbound drug is free drug which is active. When 2 highly bound drugs are given it increases the level of one of the drugs, leading to toxicity. IE warfarin and phenytoin are both highly protein bound. Low plasma protein result in more free drug. May be in elderly, so decrease dose of medication. T3 and T4 both highly protein bound. 1% of drug is powerful. Distribution – BBB (only lipid soluble will pass) – these such as narcotics, only work because they do cross BBB. Some meds we do not want to pass. Placental barrier (many drugs can pass) so be careful with drugs in pregnancy. Metabolism – liver. Chemical change of a drug structure to enhance excretion, inactivate drug, increase therapeutic action, activate prodrug, increase or decrease toxicity. Substrate – agent that is metabolized by an enzyme into a metabolite and product and eventually excreted. *Inhibitors – compete with other drugs for a particular enzyme affecting the metabolism (decreases) of the substrate and decreases the excretion of the substrate and increasing the circulating drug. Need to decrease dose of substrate if start on an inhibitor. INH increases substrate. *Inducer – competes with other drugs for a particular enzyme affecting metabolism of the substrate (increases) decreasing the efficacy of the drug. Need to increase dose of substrate if start on an inducer. IND decreases substrate. Renal excretion – passive glomerular filtration, active tubular secretion, tubular reabsorption. Pharmacogenomics: 1 question Pharmacogenomics - the study of the influence of hereditary factors on the response of individual organism to drugs, and the study of variations of DNA and RNA characteristics as related to drug response. Pharmacogenetic tests mentioned on drug labels can be classified as “test required”, “test recommended”, and “information only”. Currently there are 4 drugs requiring to have pharmacogenetic testing performed before they are prescribed: Cetuximab, Trastuzumab, Maraviroc, and Dasatinib. No genetic testing is required by the FDA for the initiation of medications such as warfarin, carbamazepine, valproic avid and abacavir are currently in place, such tests are recommended prior to initial dosing. BBW initiated in December 2007 - on carbamazepine label – testing recommended for HLA-B 1502 in patient with Asian ancestry due to high risk of developing SJS or toxic epidermal necrolysis (TEN). Drugs across the lifespan: 3 questions
Extended- Spectrum- Ticarcillin, Piperacillin Beta Lactamase Inhibitors- Clavulanic Acid, Tazobactam, Sulbactam Cephalasporins- binds to penicillin binding proteins (PBPs), disrupts cell wall synthesis, causing cell to lyse. First generation cephalosporins – gram positive cocci. Second and third generation more broad spectrum
- gram positive and gram negative. !st generation- prophylactic for surgery- never for active infection
- Cephazolin (do not give with alcohol)
- Cephalexin
- Cefadroxil 2 nd^ generation- works against URI- pneumonia from h. flu, klebsiella, pneumoniacocci, staphylococci
- Cefotetan (do not give with alcohol or drugs that promote bleeding)
- Cefprozil
- Cefoxitin
- Cefuroxime
- Cefactor 3 rd^ generation - preferred gram - , treats meningitis
- Ceftriaxone (do not give with drugs that promote bleeding, or calcium)
- Cefixime
- Cefditoren
- Cefotaxime 4 th^ generation- Used to treat HAP, pseudomonas aeruginosa
- Cefepime
- Ceftolozone 5 th^ generation- used to treat MRSA
- Ceftaroline *which can cause bleeding, which contraindicated with alcohol? If have an anaphylactic reaction, do not give PCNs or Cephalosporins. If not anaphylactic, can give cephalosporins. Vancomycin – active against MRSA, bacteriocidal, red man syndrome. Bacteriostatic inhibitors of protein synthesis: 1 question Tetracyclines - non-lethal inhibitors of protein synthesis- Broad Spectrum
Used to treat: Infectious Disease, Acne, Peptic Ulcer disease, Periodontal disease, RA, Mycoplasma Pneumoniae, helicobacter Pylori, lyme disease, anthrax, RMSF Do not give with calcium, iron, mag, aluminum, zinc, laxatives, antacids- decreases absorption- wait a couple of hours between Adverse reactions- GI irritation, staining of bones and teeth in children less than 8 years (only exception is with the infection of RMSF and doxycycline), superinfection, renal toxicity, photo sensitivity, caution of women in childbearing age.
- Diarrhea may indicate potential life-threatening superinfection
- High dose may be associated with liver damage (tetracycline- Short acting, Doxycycline- long acting, Minocycline- long acting) Macrolides (Mycins)- Bacteriostatic or Bacteriocidal- inhibit protein synthesis, broad spectrum Used if: a patient is allergic to PCNs, whooping cough, active diptheria, coryne bacterium, diptheriae, chlamydia infections, m. pneumoniae, group A strep pyogens, may also be used as an alternative for PCN G if allergic. Drug interactions- CYP3A4, Cisapride, ergotamine or dihydroergotamine, terfenadine, astemizole, lovastatin, simvastatin Adverse Effects- GI, QT prolongation and sudden cardiac death, superinfection, thrombophlebitis, transient hearing loss Clindamycin- BBW- can cause C-diff. Example: Erythromycin, (Others: Clarithromycin, Azithromycin- prolong QT) Rifampin, Metronidazole, and Floroquinolones- inhibit synthesis of DNA or RNA by binding directly to nucleic acids or interacting with enzymes required for nucleic acid synthesis Aminoglycosides MOA – inhibit protein synthesis, can cause ototoxicity and nephrotoxicity. Gentamicin – continues to exert antibacterial effects even after plasma levels decrease below detectable levels – reaction will stay for a while. Erythromycin – can prolong QT interval, so pause simvastatin while taking erythromycin! Traveler’s diarrhea – ciprofloxacin for E.Coli (gram negative bacillus) Sulfonamides – most common SE is skin reactions. Allergy to sulfa – usually skin rx. Ciprofloxacin – tendonitis and tendon rupture may occur. Drugs used for UTIs: 2 question *Tx UTIs. 80% E.Coli, then Proteus and Klebsiella. Most UTI gram- d/t cause from intestinal bacteria. Prophylaxis - SMZ/TMP- 3x/wk for 6 months
Antifungals: 1 question Onychomychosis of toenail- Terbinafine x3 months ( check liver enzymes) Fluconazole – penetrates the BBB, not safe during pregnancy, eliminated renally. ***** Tx for fungal disease SEs of antifungal medications. Systemic mycoses: amphotericin B. SE infusion reaction, nephrotoxicity, hypokalemia, bone marrow suppression. Azoles are less toxic than amphotericin B and can be given orally. Itraconazole (Sporanox) can cause cardiosuppression (do not use in HF), liver damage, inhibitor of CYP450, GI. Many are inhibitors so increases effects of substrates. Teratogenicity. STD: 1 question Chlamydia trachomatis – azithromycin, doxycycline. Erythromycin in child <45kg. Neisseria gonorrhea – cephalosporins. Nongonococcal urethritis – azithromycin, doxycycline. Syphilis – penicillin G. Herpes Simplex – acyclovir, famciclovir, valacyclovir. Genital Herpes - Valacyclovir Herpes Labialis - Penciclovir HIV prophylaxis- Truvia Bacterial Vaginosis- Metronidazole applicator x5 days (AE- neurotoxicity, risk for Ca in mice and rats, unknown for humans, disulfiram reaction when given with alcohol for 3 days before or after) Faginal Candidas- Fluconazole x Trichamonas - Metronidazole x1, Tinedazole x *review treatment of STDs Non-HIV antivirals: 1 question All antivirals either induce or inhibit CYP40 system, a lot of drug reactions. Flu meds have to be given w/in 48 hours of onset to be effective.
oseltamivir - MOA– selectively inhibits neuraminidase. Can only be given over 2 weeks and older. Given BID x5 days. SE: N/V. Zanamivir - powder form, given over the age of 7, do not give to COPD/Asthma pts due to SE or bronchospasms. Peramivir- IV, given over the age of 2, SE of diarrhea Baloxavir- 1 dose, given over the age of 12 years, not recommended in pregnant and lactating women. If having flu for more than 4 days, give supportive therapy. Headaches: 1 question Abortive VS preventive medications for HA. Aborting an ongoing attack: nonspecific analgesics (aspirin-like drugs, opioid analgesics – butorphanol, meperidine), migraine-specific drugs (Serotonin 1B1D receptor agonists – sumatriptan, all end in triptan, ergot alkaloids – ergotamine). PREVENT attack from occurring with beta blockers propranolol and metoprolol, antiepileptic drugs divalproex, topiramate, tricyclic antidepressants amitriptyline, estrogens and triptans for menstrual associated migraine. Sumatriptan (serotonin B1D1 agonist for treating acute migraine by vasoconstriction) taken in one day – 200mg. Not cause rebound HA from overuse – Propranolol is preventive (BBs, antiSZ, amitriptyline), will not cause rebound HA. All meds to treat acute migraine can cause rebound HA (sumatriptan, ibuprofen, acetaminophen). Menstrual migraine – give low dose estrogen three days prior. Trigger migraines – nitrates in hot dog. Serotonin receptor agonist – sumatriptan. Butterbur can prevent migraine, can cause liver damage. Nasally for migraines – butorphanol, sumatriptan (nasally, subque, PO). Analgesics, antagonists, nonopioid central acting antagonists: 4 questions Cox 1 - good- found in nearly all tissue- complete tasks like promoting gastric mucosa, supporting renal function, promoting platelet aggregation- blocking therapeutic effects: prevent MI, prevent stroke
*first line drug for 6 month old with fever- acetaminophen- know SE Non-Opioid Centrally acting analgesics- Tramadol (suicide risk), Clonidine, Ziconotide, Dexmedetomidine Tramadol ■ Mechanism of action- Combination of opioid and nonopioid mechanisms ■ Therapeutic use moderate to severe pain ■ Adverse effects and interactions: sedation, dizziness, headache, constipation, Seizures ■ Drug interactions
- CNS depressants ■ Abuse liability ■ Suicide ■ Preparations, dosage, and administration
- Immediate-release and extended-release Clonidine ■ Treatment of hypertension and relief of severe pain ■ Mechanism of pain relief
- Alpha 2 - adrenergic agonist ■ Analgesic use
- Used in combination with opioid analgesics ■ Adverse effects
- Cardiovascular: Severe hypotension, rebound hypertension, and bradycardia ■ Contraindications: bradycardia, hypotension Ziconotide ■ Mechanism of action
- Selective antagonist at N-type voltage-sensitive calcium channels on neurons
- Blocks calcium channels on primary nociceptive afferent neurons in dorsal horn of the spinal cord ■ Pharmacokinetics
- Distributed through cerebrospinal fluid and then transported to systemic circulation ■ Adverse effects
- CNS and muscle injury ■ Drug interactions
- Formal studies not done ■ Preparations, dosage, and administration
- Intrathecal administration Dexmedetomidine ■ Selective alpha 2 - adrenergic agonist
- Acts in the CNS to cause sedation and analgesia ■ Uses
- Short-term sedation in critically ill patients who are initially intubated and undergoing mechanical ventilation
- Sedation for nonintubated patients before or during surgical and other procedures ■ Adverse effects
- Hypotension
- Bradycardia
■ Preparations, dosage, and administration Given IV infusion with loading dose Second generation Cox 2 inhibitors – suppress inflammation, less risk gastric ulceration, increase risk heart disease!!! Give for acetaminophen overdose – acetylcysteine. Antiinflammatory Drugs and Glucocorticoids: 5 questions *SEs of glucocorticoids – major SEs- GI bleeds, increased blood sugar, negative effect on protein metabolism, decrease muscle mass, decrease protein matrix of bone causing osteoporosis and thinning of skin. central adiposity, moon face, adiposity on cervical of the spine, psychosis. Can lead to Cushing’s syndrome. If diabetic, and on glucocorticoids, sugars can go up- may need to adjust diabetic meds. *steroids used to: suppress immune response and inflammation, reducing swelling, redness, warmth, and pain. Used to treat RA, SLE, Inflammatory Bowel Disease, misc inflammatory disorders (bursitis, tendonitis, synovitis, OA, gouty arthritis, disorders of the eye. Also used to treat allergic conditions, asthma, and dermatologic disorders. Used for neoplasms, suppression of allograft rejection, and Given to mother in preterm labor in maturation of the lungs of infant. If on long term, want to get to minimum dose= 5mg/day, Be aware of adrenal suppression, need to taper if over 7 days, except for asthmatic or COPD patients, can go up to 10 days without tapering. *Do not give glucocorticoids with ASA – BBW increased risk for GI bleeds. Nonendocrine uses for glucocorticoids – RA, SLE, IBS, OA, bursitis, gout, disorders of eye. Monitor adrenal glands and endocrine system. Prolonged use of glucocorticoids – adrenal insufficiency. Principles of Neuropharmacology/PNS Pathophysiology: 2 question PNS: Parasympathetic functions – constrict pupils and bronchial smooth muscle, decreases HR, increases gastric secretions, empties bladder and bowel, digestion of food, excretion of waste, control vision, conservation of energy – muscarinic agonists, cholinergic agonists, acetylcholine function Sympathetic functions – mostly acts on vascular- maintain blood flow to brain, redistribution of blood, and compensation for loss of blood (fight or flight)- increase HR and BP, shunting blood to vital organs, dilating bronchi and pupils, mobilizing stored energy. Agonist and antagonist
Beta2: use in asthma, COPD, delay of perterm labor. Can cause hyperglycemia. Adrenergic Agonists: Epinephrine, Norepinephrine, Isoproterenol, Dopamine, Dobutamine, Phenylephrine, Albuterol, Ephedrine Epinephrine: alpha1,2, beta 1, Norepinephrine: alpha 1,2, beta 1 *selective and non selective BB (ABEAM selective) Isoproterenol for AV block, cardiac arrest Dopamine for shock, HF Dobutamine for HF Phenylephrine for nasal congestion Albuterol for asthma Ephedrine acts on all receptors Adrenergic antagonists: Alpha1 blockade (-osin): use in BPH, raynauds, phenochromocytoma. Adverse effects orthostatic hypotension, reflex tachycardia, impotence, increased sodium and blood volume. If BPH and HTN, use alpha blocker. Beta antagonists: do not use in asthma unless selective to beta1 only. Same for diabetics, beta2 can cause hyperglycemia. (ABEAM are selective) *Methyldopa is best drug for pregnant with HTN. CNS Pharmacology: 1 Question CNS medications used to relieve pain, suppression of seizures, and treatment of psychotic disorders Atropine: dilate pupil Bethanechol: GI/GU stimulation Pyridostigmine: myasthenia gravis Doxazosin: SE: HTN, BPH Albuterol: asthma inhaler Scopolamine: anticholinergic Phenylephrine: sympathomimetic (cardiac) Bethanechol: parasympathomimetic (organs)
Propranolol: adrenergic blocker Dobutamine: sympathomimetic Acetylcholine binds to muscarinic and nicotinic receptors. Atropine antidote for muscarinic agonist toxicity. Sympathomimetic is a adrenergic agonist. Muscarinic antagonist is anticholinergic. Cholinergic is muscarinic agonist and parasympathomimetic Toxicity of cholinergic: bradycardia, bronchoconstriction, pupil constriction, urinary urgency. Muscarinic antagonist toxicity opposite symptoms. Alpha1 agonists increase blood pressure. Alpha 1 antagonists decrease blood pressure. Beta 1 activation will cause bronchodilation, nonselective beta blocker causes bronchoconstriction Alpha 2 agonist (clonidine) decreases blood pressure Epinephrine in cardiac arrest, anaphylaxis, hypotension Parkinson’s: 1 question Parkinson’s: caused by low dopamine, high acetylcholine- characterized by dyskinesias(tremmors at rest, rigidity, postural instability, bradykinesia) and akinesia, motor symptoms (autonomic disturbances, depression, psychosis and dementia)- early symptoms include loss of smell, excessive salivation, clumsiness in hands, worstening handwriting, bothersome tremor, slower gait, and reduced voice volume. Treatment to cure does not exist, goal is to improve patients ability to carry out activities of daily life. Mild symptoms: MAO-B inhibitor- Selegiline or Rasagiline If respond to Levodopa, diagnosis is sure. Levodopa can also make dyskinesias worse, especially as it is given longer. Usually only good for five years, so wait to start on levodopa for as long as you can. Initially when mild start on dopamine agonist. Start to have off periods when levodopa levels drop, so combine with * MAOB inhibitor (selegilene, rosagiline) or COMT inhibitor (entacapone)- add for off periods of disease. Amantadine can also help with off periods. Shorten dosage interveral, give another drug listed above, give dopamine agonist. *Give levodopa with carbidopa, they work better together. Levodopa replaces depleted stores of dopamine Alzheimer’s Disease/Spasticity: 2 questions
Depression: 4 questions Antidepressants: first line are SSRI, SNRI, bupropion SSRI: fluoxetine, sertraline, paroxetine, fluvoxamine, escitalopram *Side effects of SSRI: sexual dysfx, nausea and vomiting in first few weeks, but resolves SNRI: venlafaxine, desvenlafaxine, duloxetine (given for neuropathies). Can give patient more energy than SSRIs. Bupropion: CNS stimulant, can help with ADHD and sexual dysfunction associated with SSRI as well. Increased risk SZ. Before starting antidepressants, check for hypothyroidism Ethosuximide: monitor for blood dysgracias TCAs: not in CAD *SSRI for children are the safest option Bipolar disorder: 2 question Lithium: mood stabilizer for BPD, Schizo…, excreted by kidneys (less excretion when sodium is low), narrow therapeutic index, monitor closely. Side effects N/V/D, thirst, ataxia, polyuria, can develop clonic movement and SZ when levels are toxic. Can use valproate, carbamazepine, lamotrigine in BPD Can use olanzapine, queitapine, aripirazole, risperidone, ziprasidone. Can cause weight gain. BPD: lithium toxicity: drowsiness and nausea Anxiety: 1 question Anxiety: benzodiazepines (alprazolam, lorazepam, diazepam, chlordiapoxide, oxazepam, chorazepate) work immediately. Can develop dependence. Buspirone: no abuse potential. Use for anxiety, and ED due to SSRI SE. Can use SSRIs when pt is anxious and depressed (escitalopram, citalopram, fluoxetine, fluvoxamine, paroxamine, sertraline). Also venlafaxine SNRI. *Buproprion SE and what it is used for? ADHD:1 question
CNS stimulants: highly addictive. Decrease appetite, insomnia are side effects. Substance abuse: 1 question Alcohol abuse: overdose S/S are vomiting, respiratory depression, hypotension, aspiration, coma. Drugs to facilitate withdrawal: benzodiazepines and adjuncts. Drugs to maintain abstinence: disulfiram, naltrexone, acamprosate. Nicotine abuse: cardiac toxicity includes vasoconstriction, accelerated HR, increased force of contraction causing HTN, increase cardiac work. Can cause tremors and convulsions. Teratogen. Pharmaceutical nicotine is safer than tobacco smoke. Bupropion: decreases urge to smoke and decreases nicotine withdrawal symptoms of anxiety and irritability. Varenicline is an agonist at nicotinic receptors and is the most effective aid for smoking cessation. Diuretics/RAS:4 questions Loop diuretics: Lasix- acts on the ascending loop of henle to block reabsorbtion , bumatide. Block sodium and chloride reabsorption. Can cause hypoelectrolytes and increase lipids and increase glucose. Thiazide: *MOA: increase renal excretion of sodium, chloride, potassium, and water to decrease BP. HCTZ- works on the early segment distal convoluted tubule, metolazone (give with Lasix to diuresis much more, give prior to giving Lasix). Chlorthalidone – older diuretic that is coming back in use for HTN. Osmotic: mannitol- promotes diuresis by creating osmotic force within lumen of the nephron. To decrease ICP, given parenterally. Potassium sparing diuretics: spironolactone – blocks aldosterone in the distal nephron, causes retention of potassium and increased excretion of sodium. (decrease mortality in HF patients), triamterene, amiloride. ACE inhibitors (-pril): use in HTN, HF, MI, diabetic and nondiabetic nephropathy. Decrease mortality in HF and MI. Prevent MI and death in high risk patients. Give diabetics ACE inhibitors and ARBs to protect the kidneys. Can cause dry cough and angioedema (bradykinin increase). Can cause hyperkalemia, check potassium one week after starting. Can cause neutropenia. Help kidney until pt has CKD and creatinine is up to 2.5 then REMOVE medication. Can cause fetal injury, teratogenic. ARBs (-sartan): same uses, same side effects (except cough!). DRIs: aliskiren, tecturna. Same side effects. Renin inhibitors: inhibits angiotensinogen to angiotensin I ACE inhibit (-pril): constrict renal blood vessels, promote sodium and water excretion, keep potassium (can cause hyperkalemia) ARBs (-sartan): block angiotensin II, promote vasodilation
Antiarrhythmics:1 question Antidysrhythmics: classifications Afib: BB, diltiazem, amiodarone if others don’t work. Aflutter: same as Afib. Easy to tx. SVT: diltiazem, BB, adenosine VT and Vfib: amiodarone, lidocaine, procainamide. Long term amiodarone and setolol. Nifedipine: HTN, migraines, angina BBs decrease adverse effects of nifedipine, but increase effects of verapamil and diltiazem. Hydralazine: can cause lupus like syndrome, check ANA if arthralgias or other symptoms. Untreated HTN leads to angina, CHF, MI, kidney disease, stroke. Treat HTN!!! Treat digoxin induced dysrhythmias: phenytoin *Amiodarone for Afib: check TSH and CXR Q6months because can cause pulmonary fibrosis!! ACE inhibit effect on failing heart: reduce preload ACE inhib can cause hyperkalemia Selective BB: atenolol, bezoprolol, esmolol, acebutalol, metoprolol – can use in diabetic and asthmatic (ABEAM) *Why do we give BB after MI?- Prevention CAD: 3 questions Risk factors include smoking, high blood pressure, high blood sugar, family history and ethnicity and certain health conditions such as metabolic syndrome, chronic kidney disease, chronic inflammatory conditions, premature menopause or pre-eclampsia and high lipid biomarkers. High LDL- tx with smoking cessation, TLC diet, and exercise- second line therapy are drugs only if TLC fails, such as HMG-CoA reductase inhibitors (Statins- Atorvastatin, Fluvastatin, Lovastatin, Pravastatin, etc), Bile sequestrants (Colesevelam), Nicotinic acid (Niacin), and Fibrates (reduce levels of TGs, not LDLs) Secondary Treatment Targets ▪ Metabolic syndrome High TG levels — 150 mg/dL or higher (or undergoing drug therapy for high TGs) Low HDL cholesterol —below 40 mg/dL for men or below 50 mg/dL for women (or undergoing drug therapy for reduced HDL)
Hyperglycemia —fasting blood glucose 100 mg/dL or higher (or undergoing drug therapy for hyperglycemia/diabetes mellitus) High blood pressure —systolic 130 mm Hg or higher and/or diastolic 85 mm Hg or higher (or undergoing drug therapy for hypertension) Waist circumference 40 inches or more for most men or 35 inches or more for most women ▪ High blood glucose ▪ High triglycerides ▪ High apolipoprotein B ▪ Low-HDL cholesterol ▪ Small LDL particles ▪ Prothrombotic state ▪ Proinflammatory state ▪ Hypertension ▪ High triglycerides ▪ Levels above 150 mg/dL HMG-CoA Reductase Inhibitors (Statins)- Reduce LDL, Elevate HDL, reduce Triglyceride Levels, promote plaque stability, reduce CV events, increase bone formation
- Administer at night
- Common SE- Headache, Rash, GI disturbances
- Drug interactions- other lipid lowering drugs, CYP3A4, teratogenic Nicotinic Acid (Niacin)-
- Common SE- flushing (intense flushing initially, can pre-treat with asprin, or can prevent with sustained release version of niacin), itching, GI upset, hepatotoxicity, hyperglycemia, gout arthritis, can raise blood levels of uric acid Bile Acid Sequestrants (colesevelam)- Reduces LDL, Increases VLDL levels in some patients by inceasing LDL receptors on hepatocytes, and preventing reabsorbtion of bile acids.
- SE- Constipation Fibric Acid Derivatives (Fibrates)- most effective drug available at lowering TG levels, Can raise HDL cholesterol, but little to no effect on LDL
- Side Effects- increased risk for bleeding in patients taking warfarin, increased risk for rhabdomyolysis in patients taking statins
- 3 available drugs: Gemfibrozil, Fenofibrate, Fenofibric acid Angina:1 question *Chronic Stable( exertional angina- brought on by emotional excitement, large meals, cold exposure, CAD): nitrates, can develop tolerance so use lowest dose and have eight hours drug free during each day. Variant (Prinzmetal or vasospastic) angina: ranolazine (new drug, good in HF), CCBs, nitrates (Beta blockers are not effective with vasospastic angina) Unstable:symptoms of angina at rest, new-onset exertional angina, intensification of existing angina= Treatment strategy is to maintain oxygen supply, and decrease oxygen demand. EKG changes. (if also
