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Nursing 6210 Patho Case Study 2
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Question 1 Patient's Chief Complaints "My breasts have been naturally cystic, but I have a new lump in my right breast that has me concerned." History of Present illness G.S. is a 46 yo white, premenopausal woman who presents for her annual physical examination. Approximately six weeks ago, the patient noticed a small, painless lump in the upper outer quadrant of her right breast. At the time, she gave this observation little thought, assuming that the lump was like the many others that she tends to develop around her menses. She states that the lumps in her breasts become palpable and bothersome approximately 10 days before the start of menstruation. At present, she is approximately four days from this start date. There is no history of dysmenorrhea associated with her periods. However, the lump failed to resolve like the others and seemed to get larger with time. The patient denies tenderness, pain, nipple discharge, and skin changes in her breasts. She also denies any masses in the axillary region of the right arm, The patient practices breast self-exams, but not routinely. She has never had a mammogram. Several years ago she had a breast biopsy that was consistent with fibrocystic changes. Her only Pap smear was done two years ago and the result was normal. Mrs. S. is married and the mother of three children—ages 3, 8, and 10 years. She breast fed all three children. Her first full-term pregnancy occurred at age 35. She had been pregnant at age 15, but terminated the pregnancy with an elective abortion. She has also suffered a first-trimester miscarriage at age 20. She has had no pregnancies in which the delivery was conducted with caesarean section. The patient's menarche occurred at age 11 years and 1 month. She has taken oral contraceptives for three years since the birth of her third child. Mrs. S. is the only child born to her parents late in life (father was 45, mother was 42). ******THERE IS NOT A QUESTION ASSOCIATED WITH QUESTION 1****** Patient’s risk factors for breast cancer include:
Cl 104 meq/L Plt 313 x 10^3/mm^3 ALT IU/L
HCO3 24 meq/L WBC 7.0 x 10^3/mm^ Alk phos IU/L
mg/dL 8 •^ Neutros^ 60%^ T bilirubin mg/dL
Cr 1.0 mg/dL •^ Lymphs^ 32%^ T protein 6.9 g/dL Glu, fasting 90 mg/dL •^ Eos^ 2%^ Alb 4.0 g/dL Chest X-Rays Lungs were clear Bilateral Mammogram There were four 1.0-1.5 cm masses diffusely distributed throughout the left breast and three 0.5- 1.0 cm masses in the right breast. There also was a 2.3 cm x 2.9 cm X 3.2 cm mass with irregular borders within the upper outer quadrant of the right breast. Associated with the suspicious lesion was diffuse skin thickening and an enlarged axillary lymph node of approximately 2.0 cm in greatest dimension. Six Y-shaped microcalcifications that extended toward the nipple were seen. There is some evidence of extension of the abnormal mass into pectoral muscle. Patient Case Question 3. Identify six distinct clinical manifestations derived from the mammogram that strongly suggest that breast cancer is present. Ultrasound Right Breast and Right Axilla
Core-Needle Biopsy of Large Right Breast Mass
- Question 3 of 6
Three microscopic findings within the tumor sample indicate that the cancer is grade I : a. Tubules in more than 75% of the sample (A = 1) b. Fewer than seven cell divisions per high-power field (B = 1) c. Very little variation in cell size (i.e., pleomorphism) (C = 1) Therefore, A + B + C = 3 —> grade I. Patient Case Question 5. Based on the grade of the cancerous mass, what is this patient's expected 10-year survival rate?
References “Breast Cancer Stages: 0 Through IV.” Breastcancer.org , 4 May 2020, www.breastcancer.org/symptoms/diagnosis/staging#stage1. “Hormone Therapy for Breast Cancer.” American Cancer Society , 18 Sept. 2019, www.cancer.org/cancer/breast-cancer/treatment/hormone-therapy-for-breast-cancer.html. McCance, Kathryn L., and Sue E. Huether. Pathophysiology. 8th ed., Elsevier, 2019. Narod, Steven A, et al. “Why Have Breast Cancer Mortality Rates Declined?” Science Direct , Elsevier, Sept. 2015, doi.org/10.1016/j.jcpo.2015.03.002. Weiss, Marissa, et al. “Metastatic Breast Cancer: Symptoms, Treatment, and More.” Breastcancer.org , 29 Jan. 2020, www.breastcancer.org/symptoms/types/recur_metast.