Nursing 6210 Patho Case Study 2, Study Guides, Projects, Research of Nursing

Nursing 6210 Patho Case Study 2

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Nursing 6210 Patho Case Study 2
Question 1
Patient's Chief Complaints
"My breasts have been naturally cystic, but I have a new lump in my right breast that has
me concerned."
History of Present illness
G.S. is a 46 yo white, premenopausal woman who presents for her annual physical examination.
Approximately six weeks ago, the patient noticed a small, painless lump in the upper outer
quadrant of her right breast. At the time, she gave this observation little thought, assuming that
the lump was like the many others that she tends to develop around her menses. She states that
the lumps in her breasts become palpable and bothersome approximately 10 days before the start
of menstruation. At present, she is approximately four days from this start date. There is no
history of dysmenorrhea associated with her periods. However, the lump failed to resolve like
the others and seemed to get larger with time. The patient denies tenderness, pain, nipple
discharge, and skin changes in her breasts. She also denies any masses in the axillary region of
the right arm,
The patient practices breast self-exams, but not routinely. She has never had a mammogram.
Several years ago she had a breast biopsy that was consistent with fibrocystic changes. Her only
Pap smear was done two years ago and the result was normal.
Mrs. S. is married and the mother of three children—ages 3, 8, and 10 years. She breast fed all
three children. Her first full-term pregnancy occurred at age 35. She had been pregnant at age 15,
but terminated the pregnancy with an elective abortion. She has also suffered a first-trimester
miscarriage at age 20. She has had no pregnancies in which the delivery was conducted with
caesarean section.
The patient's menarche occurred at age 11 years and 1 month. She has taken oral
contraceptives for three years since the birth of her third child. Mrs. S. is the only child born to
her parents late in life (father was 45, mother was 42).
****THERE IS NOT A QUESTION ASSOCIATED WITH QUESTION 1 ****
Patient’s risk factors for breast cancer include:
- First full-term pregnancy at age 35, a woman’s age when her first child is born affects
her risk for developing breast cancer, the younger she is, the lower the risk.
- Race – whites have higher incidence rates after age 40
- Estrogen exposure – early menarche (before age 12), oral contraceptives
Concerns:
- Lump is painless
- Rapid growth
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Nursing 6210 Patho Case Study 2

Question 1 Patient's Chief Complaints "My breasts have been naturally cystic, but I have a new lump in my right breast that has me concerned." History of Present illness G.S. is a 46 yo white, premenopausal woman who presents for her annual physical examination. Approximately six weeks ago, the patient noticed a small, painless lump in the upper outer quadrant of her right breast. At the time, she gave this observation little thought, assuming that the lump was like the many others that she tends to develop around her menses. She states that the lumps in her breasts become palpable and bothersome approximately 10 days before the start of menstruation. At present, she is approximately four days from this start date. There is no history of dysmenorrhea associated with her periods. However, the lump failed to resolve like the others and seemed to get larger with time. The patient denies tenderness, pain, nipple discharge, and skin changes in her breasts. She also denies any masses in the axillary region of the right arm, The patient practices breast self-exams, but not routinely. She has never had a mammogram. Several years ago she had a breast biopsy that was consistent with fibrocystic changes. Her only Pap smear was done two years ago and the result was normal. Mrs. S. is married and the mother of three children—ages 3, 8, and 10 years. She breast fed all three children. Her first full-term pregnancy occurred at age 35. She had been pregnant at age 15, but terminated the pregnancy with an elective abortion. She has also suffered a first-trimester miscarriage at age 20. She has had no pregnancies in which the delivery was conducted with caesarean section. The patient's menarche occurred at age 11 years and 1 month. She has taken oral contraceptives for three years since the birth of her third child. Mrs. S. is the only child born to her parents late in life (father was 45, mother was 42). ******THERE IS NOT A QUESTION ASSOCIATED WITH QUESTION 1****** Patient’s risk factors for breast cancer include:

  • First full-term pregnancy at age 35, a woman’s age when her first child is born affects her risk for developing breast cancer, the younger she is, the lower the risk.
  • Race – whites have higher incidence rates after age 40
  • Estrogen exposure – early menarche (before age 12), oral contraceptives Concerns:
  • Lump is painless
  • Rapid growth
  • No mammogram
  • Inconsistent self-breast exams
  • Delayed pap smears Textbook, page 796 Question 2 Physical Examination and Laboratory Tests General The patient appears well and is in no acute distress. She appears her stated age and is both alert and oriented. Vital Signs Patient Case Table 63.1 Vital Signs BP 130/84 RR 13 HT 5 ft-4 in P 74 T 98.2°F WT stable at 125 lbs HEENT Head exam normal Neck / Lymph Nodes
  • Neck supple with no JVD
  • No palpable cervical, supraclavicular, or infraclavicular adenopathy
  • One movable, firm, non-tender axillary lymph node of approximately 2 cm was palpated under the right arm
  • Thyroid non-palpable Chest / Lungs CTA and percussion Heart

Cl 104 meq/L Plt 313 x 10^3/mm^3 ALT IU/L

HCO3 24 meq/L WBC 7.0 x 10^3/mm^ Alk phos IU/L

BUN

mg/dL 8 •^ Neutros^ 60%^ T bilirubin mg/dL

Cr 1.0 mg/dL •^ Lymphs^ 32%^ T protein 6.9 g/dL Glu, fasting 90 mg/dL •^ Eos^ 2%^ Alb 4.0 g/dL Chest X-Rays Lungs were clear Bilateral Mammogram There were four 1.0-1.5 cm masses diffusely distributed throughout the left breast and three 0.5- 1.0 cm masses in the right breast. There also was a 2.3 cm x 2.9 cm X 3.2 cm mass with irregular borders within the upper outer quadrant of the right breast. Associated with the suspicious lesion was diffuse skin thickening and an enlarged axillary lymph node of approximately 2.0 cm in greatest dimension. Six Y-shaped microcalcifications that extended toward the nipple were seen. There is some evidence of extension of the abnormal mass into pectoral muscle. Patient Case Question 3. Identify six distinct clinical manifestations derived from the mammogram that strongly suggest that breast cancer is present. Ultrasound Right Breast and Right Axilla

  • Three 0.5-1.0 cm cystic lesions diffusely distributed throughout the right breast
  • Solid-appearing, non-cystic mass consistent with cancer in upper outer quadrant
  • Ill-defined mass with abnormal vascularity
  • The mass measures 2.3 cm x 2.9 cm X 3.2 cm
  • There is some suggestion of skin thickening and mild tissue edema

Core-Needle Biopsy of Large Right Breast Mass

  • Pathology was consistent with that of infiltrating breast carcinoma
  • Tubules were observed in 80-90% of the sample
  • Approximately 3-5 cell divisions were seen per high-power field and there was only a mild degree of pleomorphism
  • The tumor was positive for both estrogen and progesterone receptors Patient Case Question 4. Based on the clinical information available to this point, to which grade has this patient's cancer progressed? Patient Case Question 5. Based on the grade of the cancerous mass, what is this patient's expected 10-year survival rate? Ultrasound of Liver
  • No masses suggesting metastasis were observed
  • A 0.5 cm x 0.6 cm faintly visible region was observed to the left side and slightly cepha lad of the ligamentum venosum. The appearance of this lesion is more consistent with that of a small hemangioma than with a metastatic nodule. Bone Scan
  • No definitive evidence of bone metastasis was seen
  • Positive for mild degenerative changes of the lower lumbar spine and multiple peripheral joints consistent with degenerative joint disease Clinical Course The breast surgeon met with the patient and provided her with two treatment options: (1) lumpectomy with sentinel node biopsy, followed by breast irradiation; (2) modified radical mastectomy with sentinel node biopsy with or without reconstruction surgery. The patient also met with a radiation oncologist who discussed with her the potential benefits and side effects of radiation therapy. The patient elected breast conservation therapy and sentinel lymph node biopsy with radiation therapy. The sentinel nodes were negative and all surgical

- Question 3 of 6

  • Moving to the next question prevents changes to this answer. Question 3 Ultrasound Right Breast and Right Axilla
  • Three 0.5-1.0 cm cystic lesions diffusely distributed throughout the right breast
  • Solid-appearing, non-cystic mass consistent with cancer in upper outer quadrant
  • Ill-defined mass with abnormal vascularity
  • The mass measures 2.3 cm x 2.9 cm X 3.2 cm
  • There is some suggestion of skin thickening and mild tissue edema Core-Needle Biopsy of Large Right Breast Mass
  • Pathology was consistent with that of infiltrating breast carcinoma
  • Tubules were observed in 80-90% of the sample
  • Approximately 3-5 cell divisions were seen per high-power field and there was only a mild degree of pleomorphism
  • The tumor was positive for both estrogen and progesterone receptors

Three microscopic findings within the tumor sample indicate that the cancer is grade I : a. Tubules in more than 75% of the sample (A = 1) b. Fewer than seven cell divisions per high-power field (B = 1) c. Very little variation in cell size (i.e., pleomorphism) (C = 1) Therefore, A + B + C = 3 —> grade I. Patient Case Question 5. Based on the grade of the cancerous mass, what is this patient's expected 10-year survival rate?

  • The 10-year survival rate for a patient with stage I breast cancer is 97.8%. Sciencedirect.com Why was tamoxifen therapy initiated? Tamoxifen is a selective estrogen receptor modulator. It blocks estrogen receptors on breast cancer cells and acts like an estrogen in other tissues like the uterus and bones. This would be beneficial to a patient who has not gone through menopause. For women with hormone-receptor positive breast cancer, tamoxifen lowers the chance or recurrence and increases life expectancy. Cancer.org The patient did well with the therapeutic plan for the first 6 years and all check-ups were negative for breast cancer. At 80 months after surgery and radiation, however, the patient returned to the clinic complaining of bone pain in her lower back and left hip and a severe headache that was not responding to OTC medications. The following tests were conducted: bone scan, chest x-ray, brain MRI scan, abdominal CT scan, and laboratory blood tests. The bone scan revealed lesions in the lumbar spine without impending fracture or spinal cord compression. The chest x-ray showed three small nodules in the upper lobe of the left lung. The right lung was clear. The MRI scan revealed a small mass in the right frontal lobe. The abdominal CT scan was

References “Breast Cancer Stages: 0 Through IV.” Breastcancer.org , 4 May 2020, www.breastcancer.org/symptoms/diagnosis/staging#stage1. “Hormone Therapy for Breast Cancer.” American Cancer Society , 18 Sept. 2019, www.cancer.org/cancer/breast-cancer/treatment/hormone-therapy-for-breast-cancer.html. McCance, Kathryn L., and Sue E. Huether. Pathophysiology. 8th ed., Elsevier, 2019. Narod, Steven A, et al. “Why Have Breast Cancer Mortality Rates Declined?” Science Direct , Elsevier, Sept. 2015, doi.org/10.1016/j.jcpo.2015.03.002. Weiss, Marissa, et al. “Metastatic Breast Cancer: Symptoms, Treatment, and More.” Breastcancer.org , 29 Jan. 2020, www.breastcancer.org/symptoms/types/recur_metast.