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A concise overview of thyroid disorders, including hypothyroidism and hyperthyroidism. It covers symptoms, causes, diagnostic tests, and treatments. Key topics include thyroid hormone regulation, the hypothalamic-pituitary axis, and the effects of thyroid dysfunction on various body systems. The document also addresses specific conditions like myxedema and graves' disease, along with their respective management strategies. It serves as a quick reference for understanding thyroid-related conditions and their clinical implications. It also includes information about thyroid cancer and its treatment. Useful for medical students and healthcare professionals seeking a quick review of thyroid disorders.
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Thyroid disorders are 5-8x more common in ... - ANSWER women undiagnosed or inadequately managed hypothyroidism in pregnant women increases the risk of ... - ANSWER miscarriage premature birth severe developmental problems why do you examine the neck of your patients - ANSWER to check for goiter (enlargement of thyroid gland) 3 hormones secreted by thyroid gland - ANSWER triiodothyroine T thyroxine T calcitonin what does calcitonin do - ANSWER controls serum calcium and phosphorus _____ must be available for the synthesis of T3 and T4 - ANSWER iodine hypothalamus secretes _____ to the anterior pituitary gland - ANSWER thyrotropin releasing hormone (TRH) the anterior pituitary gland secretes _____ to the thyroid gland - ANSWER thyroid stimulating hormone (TSH) the thyroid secretes T3 and T4 which leads to .... - ANSWER increased
metabolism growth and development increased catecholamine effect thyroid function: thyroid increases _____ - ANSWER basal metabolic rate thyroid function: depending on the metabolic status the thyroid can induce _____ or _____ - ANSWER lipolysis or lipid synthesis thyroid function: thyroid stimulates the metabolism of _____ - ANSWER carbohydrates thyroid function: anabolism of _____ - ANSWER proteins thyroid function: thyroid hormones can also induce _____ in high doses - ANSWER catabolism of proteins thyroid function: permissive effects of _____ - ANSWER catecholamines thyroid function: in children, thyroid hormones act synergistically with _____ to stimulate _____ - ANSWER with growth hormones to stimulate bone growth thyroid function:
growth failure
signs of hypothyroidism - slowing of metabolic processes - ANSWER slow movement slow speech delayed relaxation of tendon reflexes bradycardia carotenemia
symptoms of hypothyroidism - accumulation of matrix substances - ANSWER dry skin hoarseness edema
signs of hypothyroidism - accumulation of matrix substances - ANSWER coarse skin puffy face loss of eye brows periorbital edema enlargement of tongue
other hypothyroid symptoms - ANSWER decreased hearing myalgia & paresthesia depression menorrhagia arthralgia pubertal delay
other hypothyroid signs - ANSWER diastolic hypertension pleural/pericardial effusions ascites galactorrhea
thyroid hormone is regulated by the - ANSWER hypothalamic-pituitary axis
abnormalities in anterior pituitary gland or the thyroid gland - ANSWER euthyroid hyperthyroidism (thyrotoxicosis) hypothyroidism
euthyroid - ANSWER normal thyroid hormone levels
60-150nml/L
normal T3 levels - ANSWER 70-190 nmol/dl
normal TBG - ANSWER 12-30 mg/L
normal TSH - ANSWER 0.5-5 mIU/L
thyroid tests - ANSWER radioiodine uptake thyroid scan thyroid ultrasound
radioiodine uptake - ANSWER 10-30% for 24 hours
iodine test
hyperthryoid vs hypothyroid - ANSWER hyper = take up too much iodine
hypo = take up too little iodine
causes of hypothyroidism - ANSWER hashimotos thyroiditis (chronic autoimmune thyroiditis)
surgical removal of gland
radioactive iodine thyroid gland ablation
external irradiation
drug induced
pituitary and hypothalamic disease
drugs that induce hypothyroidism - ANSWER lithium sulfonamides
what you see in hypothyroid patients ... - ANSWER delayed growth dull expression dry,rough yellow skin dry coarse hair
most severe form of hypothyroidism - ANSWER myxedema
myxedema - ANSWER non pitting edema caused by accumulation of mucopolysaccharides in skin
brittle hair, fatigue, weight gain
myxedema coma is _____ and _____ - ANSWER rare and life threatening
myxedema is caused by ... - ANSWER overwhelmed homeostatic mechanism (infection, hypothermia, hypoglycemia, surgery, medications)
myxedema leads to .... - ANSWER mental deterioration (confusion, psychosis, apathy) hypothermia (less than 35.5C) diastolic hypertension followed by hypotension (bradycardia, low CO) hypoventilation coma
cretinism = - ANSWER thyroid deficiency in utero
cretinism causes - ANSWER abnormalities in intellectual and physical development
medicines used to treat hypothyroidism - ANSWER synthroid (levothyroxine)
armour thyroid
hyperthyroidism (thyrotoxicosis) = excessive thyroid hormone that causes - ANSWER acceleration of metabolic processes
causes of hyperthyroidism - ANSWER autoimmune adenoma multinodular goiter subacute thyroiditis iodine induced hyperthyroidism excessive TSH
hyperthyroid cardiovascular effects - ANSWER palpitation
infiltrative dermopathy (graves disease) excessive sweating
other changes with hyper - ANSWER osteoporosis
decreased appetite and weight loss
increased risk for diabetes and thrombocytopenia
heat intolerance
exophthalmia
most frequent cause of hyperthyroidism - ANSWER graves disease
graves disease - ANSWER autoimmune disorder with a toxic diffuse goiter
main symptom of graves disease - ANSWER exophthalmos (protrusion of the eye, proptosis, and restriction of eye movement)
treatment of hyperthyroidism - ANSWER methimazole propythiouracil thyroidectomy radioactive iodine beta blockers
methimazole - ANSWER inhibits thyroid peroxidase and synthesis of thyroid hormone
when is propylthiouracil used - ANSWER when other treatments fail due to liver hepatotoxicity
severe adverse effects of hyperthyroid meds - ANSWER agranulocytosis thrombocytopenia hepatotoxicity leukopenia decreased sense of taste
oral manifestations with hypothyroid - ANSWER gingival enlargement hypercholesterolemia
ANSWER inform patient avoid surgery infection could precipitate crisis avoid (limit) epinephrine monitor vital signs
recommended guidelines for CONTROLLED hyperthyroid patients - ANSWER treat as normal treat infections early monitor vital signs
uncontrolled hyperthyroid patients are at risk of a - ANSWER thyrotoxic crisis
thyrotoxic crises are triggered by - ANSWER stress or injury
uncontrolled hyperthyroid caution with: - ANSWER resp and cardiovascular depression
epinephrine and catecholamines
uncontrolled hyperthyroid avoid: - ANSWER surgery trauma infection epinephrine
thyrotoxic crisis (thyroid storm) = - ANSWER life threatening
onset for thyroid storm - ANSWER sudden
symptoms of thyroid storm - ANSWER fever sweating excitability tachycardia nausea vomiting pulmonary edema shock (hypotension)
thyroid storm puts you at risk for ... - ANSWER lethal arrhythmias
most thyroid cancers present as .. - ANSWER enlarging thyroid nodules/masses
what may be present to indicate thyroid cancer - ANSWER change in vocal cord function enlarged cervical lymph nodes
thyroid cancer treatment - ANSWER surgery radioactive iodine I-
thyroid disease can present as ... - ANSWER hypofunction hyperfunction tumor (benign or malignant)
severe adverse outcomes of thyroid disease - ANSWER thyrotoxic crisis myxedema