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A collection of questions and answers related to various aspects of the immune system, including physical barriers, innate immunity, adaptive immunity, and the complement system. Topics covered include the role of lysosomes, defensins, mannose-binding lectin (mbl), opsonization, complement activation, chemotaxis, anaphylatoxins, diapedesis, vasodilation, inflammation, and various immune cells and their functions.
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Quiz: inate immunity ANS: Examples of physical barriers include the stratified squamous epithelium of the skin or the mucociliary escalator of the respiratory tract. QUIZ: adaptive immunity ANS: the ability to recognize and remember specific antigens and mount an attack on them QUIZ: Lysosomes ANS: an antibiotic found in tears, saliva, and other body fluids, provides a chemical barrier to infection. QUIZ: Defensins are ANS: antimicrobial peptides found in various bodily secretions QUIZ: Mannose-binding lectin (MBL) ANS: help the immune system recognize foreign invaders by binding to the unique sugars (mannose) on the surface of foreign invaders (bacteria, viruses, fungi, etc). MBL is made by the liver and circulates in plasma. QUIZ: Opsonization ANS: An immune response in which the binding of antibodies to the surface of a microbe facilitates phagocytosis of the the microbe by a macrophage QUIZ: complement activation ANS: stimulates inflammation, attracts phagocytes, and enhances phagocytosis QUIZ: complement ANS: There are approximately 20 different complement proteins that can undergo activation in several ways: 1) foreign proteins on the surface of invaders, 2) MBL attaching to sugars on foreign invaders, or 3) antigen-antibody reactions of specific immunity. QUIZ: Chemotaxis ANS: attracts immune cells to the area QUIZ: Direct cell killing ANS: (complement proteins can assemble themselves to make "holes" in bacterial cell membranes, similar to the defensins) QUIZ: anaphylatoxins ANS: C3a and C5a; directly stimulate mast cell release of histamine QUIZ: diapedesis: ANS: the passage of blood cells through the intact walls of the capillaries, typically accompanying inflammation. QUIZ: vasodilation ANS: increase in diameter of a blood vessel
QUIZ: Why would inflammation be beneficial ANS: it brings blood and nutrients to the area for healing QUIZ: C3b (opsonin) ANS: causes mast cell degranulation (release of histamine) and hence, results in inflammation. QUIZ: clotting proteins ANS: play an important role in preventing the spread of microorganisms (trap bacteria in fibrin threads). Products made during clotting stimulate inflammation. QUIZ: endothelial cells ANS: cells lining the blood vessels QUIZ: nitric oxide (NO) ANS: blood vessel dilator QUIZ: Prostacyclin ANS: inhibits blood clotting and vasoconstriction QUIZ: kinin system ANS: Functions to activate and assist inflammatory cells Primary kinin is bradykinin Causes dilation of blood vessels, pain, smooth muscle contraction, vascular permeability, and leukocyte chemotaxis QUIZ: Bradykinin ANS: which in turn dilates blood vessels and mediates pain. QUIZ: Toll-like receptors (TLRs) ANS: transmembrane protein of immune cells that recognizes pathogens and activates an immune response directed against those pathogens QUIZ: cytokines ANS: proteins secreted by cytotoxic T cells to aid in antigen destruction QUIZ: mast cells ANS: Mast cells are present in areolar (connective) tissue QUIZ: Basophils ANS: A circulating leukocyte that produces histamine. QUIZ: Histamine causes ANS: increases blood vessel permeability and increases blood flow to the area (promotes inflammation) QUIZ: Mast cells also release ANS: eukotrienes and prostaglandins. QUIZ: Leukotrienes ANS: act like histamine, but they promote a much longer and slower effect QUIZ: Prostaglandins ANS: cause smooth muscle contraction, pain, and an increase in capillary permeability
QUIZ: fibrinogen ANS: plasma protein that is converted to fibrin in the clotting process QUIZ: C-reactive protein ANS: A nonspecific protein, produced in the liver, that becomes elevated during episodes of acute inflammation or infection. QUIZ: granulomas ANS: Type IV hypersensitivity QUIZ: Antibodies (immunoglobulins): ANS: Proteins within plasma that react with antigens. QUIZ: IgA: ANS: mucosal immunity QUIZ: IgG ANS: crosses placenta and breast feeding QUIZ: IgM ANS: first antibody produced can bind to 10 pathogens QUIZ: IgE ANS: allergic reactions mast cells and basophils QUIZ: IgD ANS: Attached to B cells Activates B cells QUIZ: Mutualism ANS: A relationship between two species in which both species benefit QUIZ: Commensalism ANS: A relationship between two organisms in which one organism benefits and the other is unaffected QUIZ: Parasitism ANS: A relationship in which one organism lives on or in a host and harms it. QUIZ: Natural active immunity ANS: immunity which results from the response of the body to the invasion of a pathogen. QUIZ: Natural passive immunity ANS: acquired by a child through placenta and breast milk QUIZ: Artificial active immunity ANS: Production of one's own antibodies or T cells as a result of vaccination against disease QUIZ: Artificial passive immunity ANS: immunity which results from the administration of antibodies from another animal against a dangerous pathogen.
QUIZ: Primary (congenital) immune deficiencies ANS: are due to genetic defects from birth. According to your textbook these are more common than cystic fibrosis or childhood leukemia! QUIZ: secondary (acquired) immune deficiencies ANS: A secondary immune deficiency is due to other factors (infection, cancer, etc). QUIZ: B-cell deficiency ANS: IgA deficiency: recurrent sinus and lung infections QUIZ: T-cell deficiency: ANS: recurrent infections with fungi, viruses, protozoa QUIZ: combined immune deficiency ANS: no immunity QUIZ: