Respiratory System: Anatomy, Physiology, and Pathology - A Comprehensive Guide, Exams of Cardiology

A comprehensive overview of the respiratory system, covering its anatomy, physiology, and common pathologies. It includes detailed explanations of various respiratory conditions, such as chronic bronchitis, emphysema, asthma, and interstitial pulmonary fibrosis, along with their clinical manifestations, pathophysiology, and diagnostic findings. The document also explores lung volumes and capacities, gas exchange, and acid-base balance, providing a solid foundation for understanding respiratory function and dysfunction.

Typology: Exams

2024/2025

Available from 03/25/2025

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PCE Cardio Latest Update Graded A+
1:2 ✔✔Normal ratio of inspiration:expiration
35-40 ✔✔Normal newborn RR range
Chronic bronchitis ✔✔CXR findings: cardiomegaly, white haziness
Emphysema ✔✔CXR findings: increased black area, flattened diaphragm and ribs, narrow
mediastinum
Bullae ✔✔Dilated air space in the lung
Requires surgery to avoid pneumothorax
Extrinsic ✔✔Asthma attack due to allergic factors
Bronchiectasis ✔✔CXR findings: dilated airways, dark lung fields, flattened diaphragm, may or
may not see areas of consolidation or atelectasis
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PCE Cardio Latest Update Graded A+

1:2 ✔✔Normal ratio of inspiration:expiration

35 - 40 ✔✔Normal newborn RR range

Chronic bronchitis ✔✔CXR findings: cardiomegaly, white haziness

Emphysema ✔✔CXR findings: increased black area, flattened diaphragm and ribs, narrow mediastinum

Bullae ✔✔Dilated air space in the lung

Requires surgery to avoid pneumothorax

Extrinsic ✔✔Asthma attack due to allergic factors

Bronchiectasis ✔✔CXR findings: dilated airways, dark lung fields, flattened diaphragm, may or may not see areas of consolidation or atelectasis

High resolution CT more commonly used to help Dx

Interstitial pulmonary fibrosis ✔✔CXR findings: small contracted lungs, raised diaphragms, diffuse reticular markings

High resolution CT more commonly used

Pneumothorax ✔✔CXR findings: blackened area around lungs, flattened hemi-diaphragm

Pleural effusion ✔✔CXR findings: white in area of increased fluid, contralateral tracheal deviation, may see elevated hemidiaphragm

Pneumonia ✔✔CXR findings: air bronchograms, opacities in surrounding alveoli

Pulmonary edema ✔✔CXR findings: cardiomegaly, enlarged pulmonary vessels, white fluffy/hazy airspace, Kerley B lines

1:3 ✔✔Ratio of inspiration:expiration in obstructive diseases

I:E 3:

Heard over peripheral lung tissue

Bronchovesicular breath sounds ✔✔Inspiration is soft, low, pitched, expiration is loud, high- pitched

I:E 1:

Heard over main stem bronchi in 1st and 2nd intercostal spaces and posteriorly between the scapulae

Bronchial breath sounds ✔✔Loud, high-pitched, hollow quality

Louder on exhalation

I:E 1:1 or 1:

Distinct pause between I and E

Heard over trachea and manubrium

Crackles (rales) ✔✔Short, explosive breath sounds

Can be inspiratory or expiratory, and coarse or fine

Coarse ✔✔(Coarse/fine) crackles heard in the presence of sputum/secretions (i.e. pneumonia)

Fine ✔✔(Coarse/fine) crackles heard over fluid (i.e. in pulmonary edema), also heard in atelectasis and fibrosis

Wheezes (ronchi) ✔✔Musical breath sounds

Can be affected by coughing

Classified by pitch, timing, duration and notes

Pleural friction rub ✔✔Long, low-pitched, leathery creaking sound

Pain may be associated

Heard in pleural effusion

Stridor ✔✔Loud, musical, high-constant pitch breath sounds

Audible from a distance without a stethoscope

Most prominent during inspiration

Vital capacity (VC) ✔✔The maximum amount of gas that can be expired from the lungs following a maximum inspiration

= VT + IRV + ERV

Inspiratory capacity (IC) ✔✔The maximum amount of gas that can be inspired from the resting expiratory level

= VT + IRV

Functional residual capacity (FRC) ✔✔The amount of gas remaining in the lungs at the resting expiratory level

= ERV + RV

Forced vital capacity (FVC) ✔✔The total volume of air that can be expired after a maximal inhalation (independent of time)

Forced expiratory volume (FEV) ✔✔The maximum volume of air that can be expired from maximal inhalation in x seconds

<70 ✔✔FEV1/FVC% that indicates obstructive disease

Obstructive ✔✔FEV1 and FEV1/FVC% are both low in (obstructive/restrictive) diseases

Restrictive ✔✔FVC is low in (obstructive/restrictive) diseases

Diffusion Capacity of Carbon Monoxide (DLCO) ✔✔Tests which measure the functioning gas exchange from the lungs (alveoli) to the blood (pulmonary capillary bed)

Either ✔✔Low DLCO: problem with (pulmonary/circulatory) system?

Circulatory ✔✔High DLCO: problem with (pulmonary/circulatory) system?

7.35-7.45 ✔✔Normal pH range

35-45 ✔✔Normal PaCO2 range

22-26 ✔✔Normal HCO3- range

Hypertrophy + hyperplasia of mucous glands and goblet cells = increased mucous

Decreased # of cilia

Chronic inflammatory changes in bronchial walls

Decreased gas exchange

Chronic bronchitis ✔✔Inspection:

Obese and cyanotic

Mucus is white, yellow or green

Increased JVP and ankle edema due to association with RHF

Decreased/hyperresonant in areas of air trapping, increased/dull in areas of secretion retention ✔✔Chronic bronchitis tactile fremitus, percussion findings

Decreased breath sounds, inspiratory wet crackles ✔✔Chronic bronchitis auscultation findings

Cardiomegaly, white haziness ✔✔Chronic bronchitis CXR findings

Emphysema ✔✔Enlargement of the airway distal to the terminal bronchioles, accompanied by destruction of their walls

Centrilobar ✔✔More common form of emphysema

Affects respiratory bronchioles

Panlobar ✔✔Form of emphysema

Affects terminal and respiratory bronchioles

D/t alpha-antitrypsin deficiency

Emphysema ✔✔Pathophysiology:

Bullae may be found

Develops from an obstruction of air flow during expiration

Leads to hyperinflation --> destruction of alveolar walls --> decreased elastic recoil, increased dead space, decreased gas exchange

Emphysema ✔✔Inspection:

Thin and wasted, barrel chest

Asthma ✔✔Clinical findings include chest tightness, dyspnea, increased accessory muscle use and respiratory distress

Decreased, hyperresonant ✔✔Asthma tactile fremitus, percussion findings

Decreased breath sounds, wheezing ✔✔Asthma auscultation findings

Bronchiectasis ✔✔Irreversible, abnormal dilation of medium-sized bronchi and bronchioles resulting in airflow obstruction and secretion retention

Commonly associated with chronic inflammation and infection within these airways

Considered an extreme form of chronic bronchitis

Bronchiectasis ✔✔Pathophysiology:

Destruction of bronchial wall causing permanent dilation of airways

Ciliated walls replaced by non-ciliated, mucus-secreting cells

Pooling of infected secretions leading to recurrent infections

May cause atelectasis distal to obstruction

Bronchiectasis ✔✔Inspection findings include: thin and fatigued, clubbing, increased accessory muscle use, other signs of respiratory distress, severe cough and ++mucous that is foul-smelling, purulent and may contain blood

Decreased, hyperresonant ✔✔Bronchiectasis tactile fremitus, percussion findings

Decreased breath sounds, wheezing, possible coarse crackles ✔✔Bronchiectasis auscultation findings

Restrictive diseases ✔✔Diseases that restrict the lung from expanding fully

Difficult to get air IN

Interstitial pulmonary fibrosis (IPF) ✔✔Thickening of the interstitium of the alveolar walls which progress to fibrosis or scarring

Interstitial pulmonary fibrosis ✔✔Pathophysiology:

Decreased lung compliance

Increased elastic recoil

Acute respiratory distress syndrome (ARDS) ✔✔An acute lung injury which is characterized by respiratory distress, severe hypoxemia, and increased permeability of the alveolar-capillary membrane

Acute respiratory distress syndrome (ARDS) ✔✔Pathophysiology:

Increased permeability of capillaries d/t injury

Leads to edema in interstitial space and then into the alveoli

Decreased surfactant production leading to increased alveolar surface tension = decreased lung compliance

V/Q mismatch --> R/L shunt --> arterial hypoxemia

Rapid fibrosis in later disease progression

Increased, dull ✔✔ARDS tactile fremitus, percussion findings

Inspiratory crackles, diffuse wheezes ✔✔ARDS auscultation findings

Pneumothorax ✔✔An abnormal collection of air in the pleural space - loss of negative pressure in the pleural cavity causes expanded rib cage and/or collapsed lung

Spontaneous ✔✔Pneumothorax that develops suddenly d/t rupture in air containing structure

Most common in young tall men

Traumatic ✔✔Pneumothorax d/t penetrating or non-penetrating injury to the chest wall

Stabbing, GSW, contusion

Tension ✔✔Pneumothorax d/t tear in pleura that acts as a one-way valve

Air enters into pleural space during inhalation, but air doesn't leave during exhalation

Medical emergency

Pneumothorax ✔✔Inspection findings:

Signs of respiratory distress

Dyspnea

Increased RR

CHEST PAIN

Dry cough d/t irritation of pleural receptors

C3-C5 ✔✔Phrenic nerve innervation

T1-T12 ✔✔Intercostals innervation

T6-L1 ✔✔Abdominals innervation

Cystic fibrosis ✔✔Systemic hereditary disease of the exocrine glands of the body

Results in copious amount of thick secretions

Cystic fibrosis ✔✔Pathophysiology:

Most commonly manifests in lungs, liver, kidneys, and intestine

Ion transport dysfunction = increased electrolyte content in sweat

Increased obstruction of exocrine ducts by thick secretion

Increased secretion retention in lungs leads to recurrent lung infections, fibrosis/scarring

Malabsorption of nutrients

Cystic fibrosis ✔✔Inspection findings: low weight, copious amounts of mucopurulent, or purulent mucous, increased RR, barrel chest, clubbing, chronic productive cough

Decreased breath sounds, inspiratory/expiratory crackles, wheezes ✔✔Cystic fibrosis auscultation findings

Mixed ✔✔Cystic fibrosis tactile fremitus/percussion findings

Pneumonia ✔✔An acute inflammation of the lungs associated with alveolar filling by exudates (consolidation)

Common complication and cause of morbidity and mortality in hospitalized patients

Increased, dull ✔✔Pneumonia tactile fremitus, percussion findings

Wet inspiratory crackles, bronchial or bronchovesicular BS ✔✔Pneumonia auscultation findings

Productive, high ✔✔Cough & fever Sx in bacterial pneumonia