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A comprehensive overview of the respiratory system, covering its anatomy, physiology, and common pathologies. It includes detailed explanations of various respiratory conditions, such as chronic bronchitis, emphysema, asthma, and interstitial pulmonary fibrosis, along with their clinical manifestations, pathophysiology, and diagnostic findings. The document also explores lung volumes and capacities, gas exchange, and acid-base balance, providing a solid foundation for understanding respiratory function and dysfunction.
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1:2 ✔✔Normal ratio of inspiration:expiration
35 - 40 ✔✔Normal newborn RR range
Chronic bronchitis ✔✔CXR findings: cardiomegaly, white haziness
Emphysema ✔✔CXR findings: increased black area, flattened diaphragm and ribs, narrow mediastinum
Bullae ✔✔Dilated air space in the lung
Requires surgery to avoid pneumothorax
Extrinsic ✔✔Asthma attack due to allergic factors
Bronchiectasis ✔✔CXR findings: dilated airways, dark lung fields, flattened diaphragm, may or may not see areas of consolidation or atelectasis
High resolution CT more commonly used to help Dx
Interstitial pulmonary fibrosis ✔✔CXR findings: small contracted lungs, raised diaphragms, diffuse reticular markings
High resolution CT more commonly used
Pneumothorax ✔✔CXR findings: blackened area around lungs, flattened hemi-diaphragm
Pleural effusion ✔✔CXR findings: white in area of increased fluid, contralateral tracheal deviation, may see elevated hemidiaphragm
Pneumonia ✔✔CXR findings: air bronchograms, opacities in surrounding alveoli
Pulmonary edema ✔✔CXR findings: cardiomegaly, enlarged pulmonary vessels, white fluffy/hazy airspace, Kerley B lines
1:3 ✔✔Ratio of inspiration:expiration in obstructive diseases
Heard over peripheral lung tissue
Bronchovesicular breath sounds ✔✔Inspiration is soft, low, pitched, expiration is loud, high- pitched
I:E 1:
Heard over main stem bronchi in 1st and 2nd intercostal spaces and posteriorly between the scapulae
Bronchial breath sounds ✔✔Loud, high-pitched, hollow quality
Louder on exhalation
I:E 1:1 or 1:
Distinct pause between I and E
Heard over trachea and manubrium
Crackles (rales) ✔✔Short, explosive breath sounds
Can be inspiratory or expiratory, and coarse or fine
Coarse ✔✔(Coarse/fine) crackles heard in the presence of sputum/secretions (i.e. pneumonia)
Fine ✔✔(Coarse/fine) crackles heard over fluid (i.e. in pulmonary edema), also heard in atelectasis and fibrosis
Wheezes (ronchi) ✔✔Musical breath sounds
Can be affected by coughing
Classified by pitch, timing, duration and notes
Pleural friction rub ✔✔Long, low-pitched, leathery creaking sound
Pain may be associated
Heard in pleural effusion
Stridor ✔✔Loud, musical, high-constant pitch breath sounds
Audible from a distance without a stethoscope
Most prominent during inspiration
Vital capacity (VC) ✔✔The maximum amount of gas that can be expired from the lungs following a maximum inspiration
= VT + IRV + ERV
Inspiratory capacity (IC) ✔✔The maximum amount of gas that can be inspired from the resting expiratory level
= VT + IRV
Functional residual capacity (FRC) ✔✔The amount of gas remaining in the lungs at the resting expiratory level
= ERV + RV
Forced vital capacity (FVC) ✔✔The total volume of air that can be expired after a maximal inhalation (independent of time)
Forced expiratory volume (FEV) ✔✔The maximum volume of air that can be expired from maximal inhalation in x seconds
<70 ✔✔FEV1/FVC% that indicates obstructive disease
Obstructive ✔✔FEV1 and FEV1/FVC% are both low in (obstructive/restrictive) diseases
Restrictive ✔✔FVC is low in (obstructive/restrictive) diseases
Diffusion Capacity of Carbon Monoxide (DLCO) ✔✔Tests which measure the functioning gas exchange from the lungs (alveoli) to the blood (pulmonary capillary bed)
Either ✔✔Low DLCO: problem with (pulmonary/circulatory) system?
Circulatory ✔✔High DLCO: problem with (pulmonary/circulatory) system?
7.35-7.45 ✔✔Normal pH range
35-45 ✔✔Normal PaCO2 range
22-26 ✔✔Normal HCO3- range
Hypertrophy + hyperplasia of mucous glands and goblet cells = increased mucous
Decreased # of cilia
Chronic inflammatory changes in bronchial walls
Decreased gas exchange
Chronic bronchitis ✔✔Inspection:
Obese and cyanotic
Mucus is white, yellow or green
Increased JVP and ankle edema due to association with RHF
Decreased/hyperresonant in areas of air trapping, increased/dull in areas of secretion retention ✔✔Chronic bronchitis tactile fremitus, percussion findings
Decreased breath sounds, inspiratory wet crackles ✔✔Chronic bronchitis auscultation findings
Cardiomegaly, white haziness ✔✔Chronic bronchitis CXR findings
Emphysema ✔✔Enlargement of the airway distal to the terminal bronchioles, accompanied by destruction of their walls
Centrilobar ✔✔More common form of emphysema
Affects respiratory bronchioles
Panlobar ✔✔Form of emphysema
Affects terminal and respiratory bronchioles
D/t alpha-antitrypsin deficiency
Emphysema ✔✔Pathophysiology:
Bullae may be found
Develops from an obstruction of air flow during expiration
Leads to hyperinflation --> destruction of alveolar walls --> decreased elastic recoil, increased dead space, decreased gas exchange
Emphysema ✔✔Inspection:
Thin and wasted, barrel chest
Asthma ✔✔Clinical findings include chest tightness, dyspnea, increased accessory muscle use and respiratory distress
Decreased, hyperresonant ✔✔Asthma tactile fremitus, percussion findings
Decreased breath sounds, wheezing ✔✔Asthma auscultation findings
Bronchiectasis ✔✔Irreversible, abnormal dilation of medium-sized bronchi and bronchioles resulting in airflow obstruction and secretion retention
Commonly associated with chronic inflammation and infection within these airways
Considered an extreme form of chronic bronchitis
Bronchiectasis ✔✔Pathophysiology:
Destruction of bronchial wall causing permanent dilation of airways
Ciliated walls replaced by non-ciliated, mucus-secreting cells
Pooling of infected secretions leading to recurrent infections
May cause atelectasis distal to obstruction
Bronchiectasis ✔✔Inspection findings include: thin and fatigued, clubbing, increased accessory muscle use, other signs of respiratory distress, severe cough and ++mucous that is foul-smelling, purulent and may contain blood
Decreased, hyperresonant ✔✔Bronchiectasis tactile fremitus, percussion findings
Decreased breath sounds, wheezing, possible coarse crackles ✔✔Bronchiectasis auscultation findings
Restrictive diseases ✔✔Diseases that restrict the lung from expanding fully
Difficult to get air IN
Interstitial pulmonary fibrosis (IPF) ✔✔Thickening of the interstitium of the alveolar walls which progress to fibrosis or scarring
Interstitial pulmonary fibrosis ✔✔Pathophysiology:
Decreased lung compliance
Increased elastic recoil
Acute respiratory distress syndrome (ARDS) ✔✔An acute lung injury which is characterized by respiratory distress, severe hypoxemia, and increased permeability of the alveolar-capillary membrane
Acute respiratory distress syndrome (ARDS) ✔✔Pathophysiology:
Increased permeability of capillaries d/t injury
Leads to edema in interstitial space and then into the alveoli
Decreased surfactant production leading to increased alveolar surface tension = decreased lung compliance
V/Q mismatch --> R/L shunt --> arterial hypoxemia
Rapid fibrosis in later disease progression
Increased, dull ✔✔ARDS tactile fremitus, percussion findings
Inspiratory crackles, diffuse wheezes ✔✔ARDS auscultation findings
Pneumothorax ✔✔An abnormal collection of air in the pleural space - loss of negative pressure in the pleural cavity causes expanded rib cage and/or collapsed lung
Spontaneous ✔✔Pneumothorax that develops suddenly d/t rupture in air containing structure
Most common in young tall men
Traumatic ✔✔Pneumothorax d/t penetrating or non-penetrating injury to the chest wall
Stabbing, GSW, contusion
Tension ✔✔Pneumothorax d/t tear in pleura that acts as a one-way valve
Air enters into pleural space during inhalation, but air doesn't leave during exhalation
Medical emergency
Pneumothorax ✔✔Inspection findings:
Signs of respiratory distress
Dyspnea
Increased RR
CHEST PAIN
Dry cough d/t irritation of pleural receptors
C3-C5 ✔✔Phrenic nerve innervation
T1-T12 ✔✔Intercostals innervation
T6-L1 ✔✔Abdominals innervation
Cystic fibrosis ✔✔Systemic hereditary disease of the exocrine glands of the body
Results in copious amount of thick secretions
Cystic fibrosis ✔✔Pathophysiology:
Most commonly manifests in lungs, liver, kidneys, and intestine
Ion transport dysfunction = increased electrolyte content in sweat
Increased obstruction of exocrine ducts by thick secretion
Increased secretion retention in lungs leads to recurrent lung infections, fibrosis/scarring
Malabsorption of nutrients
Cystic fibrosis ✔✔Inspection findings: low weight, copious amounts of mucopurulent, or purulent mucous, increased RR, barrel chest, clubbing, chronic productive cough
Decreased breath sounds, inspiratory/expiratory crackles, wheezes ✔✔Cystic fibrosis auscultation findings
Mixed ✔✔Cystic fibrosis tactile fremitus/percussion findings
Pneumonia ✔✔An acute inflammation of the lungs associated with alveolar filling by exudates (consolidation)
Common complication and cause of morbidity and mortality in hospitalized patients
Increased, dull ✔✔Pneumonia tactile fremitus, percussion findings
Wet inspiratory crackles, bronchial or bronchovesicular BS ✔✔Pneumonia auscultation findings
Productive, high ✔✔Cough & fever Sx in bacterial pneumonia