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Pedigree Worksheet: Understanding Genetic Inheritance Patterns, Summaries of Genetics

Ahlia University (AU)Genetics

When working through a pedigree, the first thing you need to do is figure out which characteristic is dominant – the shaded one or the un-shaded one. Then you ...

Typology: Summaries

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Pedigree Worksheet Name _____________________________
Period _______ Date _______________
Interpreting a Human Pedigree
Use the pedigree below to answer 1-5
1. In a pedigree, a square represents a male. If it is darkened he has hemophilia; if clear, he had normal blood
clotting.
a. How many males are there? __________________
b. How many males have hemophilia? ____________
2. A circle represents a female. If it is darkened, she has hemophilia; if open she is normal.
a. How many female are there? _________________
b. How many females have hemophilia? __________
3. A marriage is indicated by a horizontal line connecting a circle to a square.
a. How many marriages are there? _______________
4. A line perpendicular to a marriage line indicates the offspring. If the line ends with either a circle or a square,
the couple had only one child. However, if the line is connected to another horizontal line, then several children
were produced, each indicated by a short vertical line connected to the horizontal line. The first child born
appears to the left and the last born to the right.
a. How many children did the first couple (couple in row I) have? ______________
b. How many children did the third couple (couple in row III) have? _____________
5. Level I represent the first generation, level II represents the second generation.
a. How many generations are there? _______________
b. How many members are there in the fourth generation? _____________
Use the pedigree below to answer 6-12
Shaded individuals have Huntington’s Disease
6. Write the generation on the pedigree numbers (roman numerals).
7. Which members of the family above are afflicted with Huntington’s Disease? ____________________________
8. There are no carriers for Huntington’s Disease- you either have it or you don’t.
With this in mind, is Huntington’s disease caused by a dominant or recessive trait? ___________________
9. How many children did individuals I-1 and I-2 have? _______________________________________________
10. How many girls did II-1 and II-2 have? __________ How many have Huntington’s Disease? _______________
11. How is individual III-2 and II-4 related? _____________________ I-2 and III-5? ______________________________
12. Write the genotypes of each individual on the pedigree.
Pedigree Worksheet 1 of 3
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Pedigree Worksheet Name _____________________________ Period _______ Date _______________ Interpreting a Human Pedigree Use the pedigree below to answer 1-

  1. In a pedigree, a square represents a male. If it is darkened he has hemophilia ; if clear, he had normal blood clotting. _a. How many males are there? ___________________ _b. How many males have hemophilia? _____________
  2. A circle represents a female. If it is darkened , she has hemophilia ; if open she is normal. _a. How many female are there? __________________ _b. How many females have hemophilia? ___________
  3. A marriage is indicated by a horizontal line connecting a circle to a square. a. How many marriages are there? _______________
  4. A line perpendicular to a marriage line indicates the offspring. If the line ends with either a circle or a square, the couple had only one child. However, if the line is connected to another horizontal line, then several children were produced, each indicated by a short vertical line connected to the horizontal line. The first child born appears to the left and the last born to the right. _a. How many children did the first couple (couple in row I) have? _______________ _b. How many children did the third couple (couple in row III) have? ______________
  5. Level I represent the first generation, level II represents the second generation. _a. How many generations are there? ________________ _b. How many members are there in the fourth generation? ______________

Use the pedigree below to answer 6- Shaded individuals have Huntington’s Disease

  1. Write the generation on the pedigree numbers (roman numerals).
  2. Which members of the family above are afflicted with Huntington’s Disease? ____________________________
  3. There are no carriers for Huntington’s Disease- you either have it or you don’t. With this in mind, is Huntington’s disease caused by a dominant or recessive trait? ___________________
  4. How many children did individuals I-1 and I-2 have? _______________________________________________
  5. How many girls did II-1 and II-2 have? __________ How many have Huntington’s Disease? _______________
  6. How is individual III-2 and II-4 related? _____________________ I-2 and III-5? ______________________________
  7. Write the genotypes of each individual on the pedigree.

Use the Pedigree below to answer 13-

  1. Write the generation on the pedigree numbers (roman numerals). The pedigree to the above shows the passing on of Hitchhiker’s Thumb in a family. Is this trait dominant or recessive? ____________________
  2. How do you know? ______________________
  3. How are individuals III-1 and III-2 related? ________________________
  4. Name 2 individuals that have hitchhiker’s thumb. __________________
  5. Name 2 individuals that were carriers of hitchhiker’s thumb. ______________
  6. Write the genotypes for each individual on the pedigree.

Determining Inheritance Patterns

  1. When working through a pedigree, the first thing you need to do is figure out which characteristic is dominant – the shaded one or the un-shaded one. Then you need to choose a letter (let’s use A) and begin assigning genotypes. Remember that recessive individuals are always homozygous, so assign their genotypes first. Then go back and look at all of the dominant individuals. For some, you will only be able to determine one allele of the genotype, so just write the one capital allele followed by a question mark (A?).

a. Which characteristic is dominant? ________________________ b. Which characteristic is recessive? ________________________ c. Determine the genotypes of all individuals. You will have three “A?”. Write your Genotypes beneath each individual.