Pharmaceutical aerosol, Lecture notes of Pharmacy

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PRESENTATION

ON

PHARMACEUTICAL AEROSOLS

Presented By: Diganta Das

Content

• Definition
• Advantages & Disadvantages of Aerosols
• Classification of Aerosols
• Components
• Propellants
• Types of aerosol systems
• Filling of Aerosols
• Quality control Test of aerosols
• Reference

Advantages of Aerosols

• The medication can be delivered directly to the affected area in a desired form
• The hydrolysis of medicament can be prevented
• The sterility of the product can be maintained
• The application of medicament is easier
• Manual contact with medicaments can be avoided

Disadvantages of Aerosols

• Aerosols are costly preparation
• Some of the propellants are very toxic
• Lots of difficulties are faced in aerosol formulation when the drug is not soluble in propellant
• The cooling effect of highly volatile propellants may cause discomfort on injured skin

Components

Following components: ▪ Containers ▪ Valve ▪ Actuator ▪ Concentrate containing the active ingredient ▪ Propellant

Container

• In Pharmaceutical aerosols containers are made from metal (such as tin, steel, aluminum and stainless steel), glass and plastic
• These containers can withstand high pressure

Actuator

• Actuator is fitted on the valve stem
• It helps in the easy opening and closing of the valve, whenever it is required
• This is used to ensure that the product is delivered properly in the desired form

Dip tubes

• It conveys the liquid from the bottom of the container to the dispensing valve at the top
• The dip tubes are made from polyethylene or polypropylene

Types of aerosol systems

1. Solution system(Two-phase Systems)

2. Water based system(Emulsion Systems)

3. Suspension systems(Dispersion Systems)

4. Foam systems

Filling of Aerosols

• Both manufacturing procedures and packaging are carried simultaneously
• To prepare and package pharmaceutical aerosols successfully, special knowledge, skills and equipment are required
• Includes three equipment:
  1. Pressure filling apparatus
  2. Cold filling apparatus
  3. Compressed gas filling apparatus

Reference

• Lachman L, Lieberman HA, Kanig JL. 'Theory and Practice of Industrial pharmacy'- Varghese publishing house, 3rd edition, Varghese Publishing House, Bombay, 1991, pg. no- 457 - 477
• Niazi SK. "Handbook of Pharmaceutical Manufacturing Formulation :Liquid products", CRC Press LLC, 2004.
• Dr. B. Prakash Rao, S. Rajarajan, Dr. Beny Baby.“Text book of Industrial Pharmacy-I” published by Nirali Prakashan, First edition, 2019, pg. no- 214 - 248

Thank You