PHARMACEUTICAL CALCULATION PACOP COMPILED, Exams of Pharmaceutical Statistics

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PHARMACEUTICAL CALCULATION PACOP COMPILED

Subject: PHARMACEUTICAL CALCULATIONS (VIOLET)

1. A 15-g tube of Triamcinolone acetonide 0.025% is prescribed for one of your patients. How much triamcinolone acetonide is present in the preparation? A. 3.75 g B. 3.75 mg C. 3.5 g D. 0.375 g E. 0.025 mg 2. If a 1-lb jar of ointment contains 55 g of active ingredient, what is the percent concentration of active ingredient in preparation? A. 12% B. 15% C. 5.5% D. 10% E. 55% 3. A medication order calls for 750 mL of D 5 W to be infused over a 10-hour period. If an IV administration set (^) that delivers 10 drops/mL is to be used, how many drops per minute should be delivered to the patient? A. 11 drops B. 10 drops C. 13 drops D. 7.5 drops E. 8 drops 4. An oral solution contains 75mg of active drug per ml. How many milligrams of active drug would there be in calculated dose 0.5mL? A. 37.5 mg B. 50 mg C. 75 mg D. 7.5 mg E. 0.5 mg 5. A patient is prescribed a potassium chloride elixir that contains 20 mEq of potassium ion in each 15 mL of elixir. How many milliliters should the patient take to provide 40 mEq of potassium ion? A. 20 mL B. 15 mL C. 30 mL D. 40 mL E. 50 mL 6. The recommended dose for drug is 5 mg per kg of a patient’s weight. If the drug comes in a preparation containing 15mg/5ml, what would be the dose, in mL, for a patient weighing 15 kg? A. 30 mL B. 25 mL C. 15 mL D. 10 mL E. 20 mL 7. An injectable drug contains 2.5 mg of dug per 5 ml vial. If patient’s dose id determined to be 150 mcg, how many mL of the drug should be administered to the patient? A. 0.3 mL B. 0.5 mL C. 0.1 mL D. 0.2 mL E. 0.4 mL 8. How many grams of digoxin would be required to make 15,000 tablets each containing 250 mcg of digoxin? A. 500 g B. 3.75 g C. 2.5 g D. 5 g

B. 2 mL C. 7.5 mL D. 0.4 mL E. 0.8 mL

10. An oral inhalation for asthma contains 100 mcg of mometasone furoate and 5 mcg of formoterol fumarate per inhalation. If the patient is directed to use the inhaler as “two inhalations twice daily”, what would be the amount of each drug inhaled daily? The answers should be expressed in mg. A. 0.2 mg mometasone, 0.1 mg formoterol B. 0.4 mg mometasone, 0.2 mg formoterol C. 0.6 mg mometasone, 0.3 mg formoterol D. 0.8 mg mometasone, 0.04 mg formoterol E. 1 mg mometasone, 0.05 mg formoterol 11. A prefilled syringe contains 2 mg of active drug in 5 ml of solution. How many micrograms of drug is administered by injecting 0.5 ml of the solution? A. 0.2 mcg B. 400 mcg C. 0.4 mcg D. 200 mcg E. 215 mcg 12. A salbutamol inhaler contains 75 mcg of drug per inhalation. How many inhalation does could be delivered if the inhaler contains 20 mg of salbutamol? A. 267 inhalations B. 250 inhalations C. 325 inhalations D. 472 inhalations E. 752 inhalations 13. What does the abbreviation p.r.n. means? A. As needed B. By mouth C. Repeat D. At bedtime E. As directed 14. An otic solution contains 0.2 mg of active ingredient in 2.5 mL containers. What is the percent strenght of the active ingredient in the solution? A. 0.08% w/v B. 0.008% w/v C. 0.04% w/v D. 0.95% E. None of these 15. R x (^) Potassium permanganate 0.03% Purified water ad. 250 mL Sig. As directed Determine the amount of potassium permanganate that should be used to compound the prescription. A. 30 g B. 0.075 g C. 0.3 g D. 7.5 g E. 260 g 16. R x (^) Ofloxacin ophthalmic solution 0.3% Disp. 5 mL Determine the amount in milligrams of Ofloxacin contained each mL of the prescription. A. 3 mg B. 3.7 mg C. 10.2 mg D. 12.5 mg E. 1.72 mg 17. The following are the recommended doses for a certain

nicotine patch One 21 mg dose per day for 6 weeks One 14 mg dose per day for 2 weeks One 7 mg dose per day for 2 weeks

PhP 2350.00 per kilogram. A. PhP 5225. B. PhP 6543. C. PhP 5376.

D. PhP 1227. E. PhP 2453.

25. Determine the density of 125 mL of liquid, weighing 278g. A. 2. B. 3. C. 22. D. 2. E. 3. 26. What is the weight in kilograms of 2 L of a liquid with a specific gravity of 0.97? A. 1.75 kg B. 1.94 kg C. 1.27 kg D. 1.57 kg E. 1.87 kg 27. Determine the volume, in mL, of 3 lb of benzyl benzoate having a specific gravity of 1.12. A. 1216 mL B. 1500 mL C. 1362 mL D. 1000 mL E. 2560 mL 28. Given the following formulation, determine the total of weight of the formula for a chewable gummy gel medication base. Gelatin 400g Glycerin 150 mL (sp gr 1.25) Purified water 25 mL A. 75 g B. 612.5 g C. 325.5 g D. 273.5 g E. 204.5 g 29. If the dose of a drug is 50 mcg how many doses are in 0.04 g? A. 250 doses B. 750 doses C. 800 doses D. 415 doses E. 525 doses 30. A patient has a prescription with a signa of “2 tbsp b.i.d. 8 d.” What is the total volume of medication to be dispensed to complete the therapy? A. 240 mL B. 180 mL C. 300 mL D. 500 mL E. 480 mL 31. If the given dose for a given drug is 550 mcg per kilogram of the body weight, how many milligrams should be given to a patient weighing 60 lbs.? A. 15 mg B. 25 mg C. 20 mg D. 10 mg E. 30 mg 32. A patient weighing 110 lb was administered 2.3 g of a drug supposed to be dosed at 32mg/kg. Was the administered dose correct? Or is the patient under dosed or overdosed? A. Correct B. Under dosed C. Overdosed D. Cannot be determined E. None of these 33. Rx Erythromycin ethylsuccinate 400mg/ mL Disp. 100 mL Sig. Tsp q.i.d. until all medication is taken

C. 3 mL

D. 0.5 mL E. 1.5 mL

41. Calculate the pediatric dose for a drug with an adult dose of 120 mg for a child who is 5 years old, 40 inches high, and weighs 35 lb. Use Young’s Rule. A. 25.24 mg B. 35.29 mg C. 27.13 mg D. 28.15 mg E. None of these 42. Over the counter dextromethorpan is available as 120mg/60 mL bottle. If the dose for 6 year old child is determined to be 1 ½ teaspoons, how many milligrams of dextromethorpan is present in one dose? A. 10 mg B. 15 mg C. 20 mg D. 25 mg E. 30 mg 43. A prescription for enoxaparin sodium (Lovenox) indicates a dose of 1 mg/kg subcutaneously q 12 h. The drug is available in a prefilled syringe of 100 mg/1 mL of enoxaparin sodium. How many mL of the drug should be administered to 218 lb patient per dose> A. 1 mL B. 2 mL C. 3 mL D. 4 mL E. 5 mL 44. Cyclosporine, an immunosuppressive agent, is administered before and after organ transplant, and is given as a single dose of 15 mg/kg body weight. How many mL of a 30 mL bottle containing 125 mg of cyclosporine per mL would be administered to a 145 lb kidney transplant patient? A. 3.5 mL B. 2.7 mL C. 7.9 mL D. 9.2 mL E. 5.4 mL 45. A prescription for digoxin indicates a dose of 10 mcg/kg for a 7 lb neonate. If the available preparation of digoxin is 0.26mg/mL injection, how may mL should be administered to this patient? A. 0.13 mL B. 0.10 mL C. 0.32 mL D. 0.25 mL E. 0.01 mL 46. How many mL of a U-100 insulin preparation should be administered to obtain a dose of 60 units of insulin? A. 0.1 mL B. 6 mL C. 0.6 mL D. 0.06 mL E. 1 mL 47. Heparin sodium injection contains 200,000 units in 10 mL. How many mL would contain 8,000 units of heparin? A. 0.7 mL B. 0.6 mL C. 0.5 mL D. 0.4 mL E. 0.3 mL 48. A diabetic patient injects 30 units of insulin BID. How long would a 10 mL vial of U- insulin last this patient? A. 10 Days B. 16 Days C. 24 Days D. 28 Days E. 30 Days

B. 5 days C. 6 days D. 8 days E. 10 days

50. Saint John’s Wort is administered as 100 mg capsules to be taken TID, if this herb is standardized to contain 0.5% hypericin extract, how many mg of the extract would taken daily? A. 0.5 mg B. 1.5 mg C. 100 mg D. 50 mg E. 150 mg 51. A hospital medication order calls for isophane insulin suspension to be administered to a 145 lb patient on the basis of 1 unit/kg per 24 hours. How many units of isophane insulin suspension should be administered safely for this patient? A. 65.9 units per 24 hours B. 67.2 units per 24 hours C. 66.3 units per 24 hours D. 68.5 units per 24 hours E. 69.1 units per 24 hours 52. Creon, a pancrealipase product, contains 3000 units of lipase, 9,500 units of protease, and 15,000 units if amylase in a delayed-release capsule. The instruction is for the capsules to be swallowed whole or the contents added uncrushed to food immidiately prior to administration. The dose should not exceed 2,500 lipase units/kg body weight. If the content of one capsule is added to 180 ml feeding formula for 15 lb infant, is the dose within acceptable limits? A. Yes, it is within the acceptable limits B. No, it is not within the acceptable limits C. It cannot be determined given the data D. All of these. E. None of these. 53. A cancer patient is taking one 30 mg oxycodone tablet q 6 h p.r.n. pain. The patient’s pain management doctor decides to switch the patient to fentanyl transdermal patches. Referring to the data below, what strength of the patches should be prescribed to this patient? Daily Dose (mg/day) Oral Oxycodone 30-67 67.5 – 112 112.5 – 157 157.5 – 202 Fentanyl TDS 25 mcg/hr 50 mcg/hr 75 mcg/hr 100 mcg/hr A. No need to change patches B. 25 mcg/hr C. 50 mcg/hr D. 75 mcg/hr E. 100 mcg/hr 54. Using the Cockcroft-Gault Equation, determine the creatinine clearance rate for an 80 year old male patient weighing 72 kg and having a serum creatinine of 1.5 mg/dL A. 25 mL/min B. 40 mL/min C. 35 mL/min D. 10 mL/min E. 45 mL/min 55. A medication order indicates 1500 Units of heparin to be administered via intravenous infusion per hour. The pharmacy provides a heparin IV bag containing 20,000 units of heparin in 250 mL D 5 W. Determine how many (^) mL should be administered per minute. A. 0.1 mL/min B. 0.2 mL/min C. 0.3 mL/min D. 0.4 mL/min E. 0.5 mL/min 56. Interpret the following signa: Sig. gtt iii each eye q 4 h p.r.n pain A. Instill 3mL into each eye for pain

B. Instill 3 drops into each eye every 4 hours as needed for pain C. Take 3 mL for each eye every 4 hours for pain

A. 100 inhalations B. 200 inhalations C. 250 inhalations D. 300 inhalations

E. 400 inhalations

65. A patient was administered 200 mL of D 5 W at a rate of 20mL/hr. If the infusion was begun at 10 AM, what (^) time was the infusion completed? A. 10 PM B. 6 PM C. 8 PM D. 2 PM E. 12 PM 66. A pediatric is administered 75 mL of an infusion at 10 drops/min. Determine the duration of the infusion in minutes if an administration set that delivers 30 drops/mL is used? A. 450 minutes B. 400 minutes C. 350 minutes D. 300 minutes E. 350 minutes 67. An emergency syringe contains 1 g/5 of lidocaine. How many mL should be used to prepare 125 mL of an infusion to^ contain^2 mg/mL^ of lidocaine^ in D 5 W? A. 2.25 mL B. 2.0 mL C. 1.25 mL D. 1.5 mL E. 1.0 mL 68. An intravenous drip contains 3 g lidocaine hydrochloride and is administered t a rate of 5 mg/min. What is the total time, in minutes, to complete the infusion? A. 600 minutes B. 500 minutes C. 400 minutes D. 300 minutes E. 200 minutes 69. A 160 lb patient has been administered intravenous immunoglobulin (IVIG) at a rate of 0. mL/kg/min. How many mL is administered over a period of 6 hours? A. 1420 mL B. 1309 mL C. 1255 mL D. 1150 mL E. 1030 mL 70. A pharmacist receives a medication order for 400,000 units of penicillin G potassium to be added to 500 mL of D 5 W. The direction on the vial reads that if 1.5 mL of solvent is added, the solution, containing 1,000,000 units will now measure 2 mL. Determine the amount of solution that should be added to D 5 W? A. 0.5 mL B. 0.8 mL C. 1 mL D. 1.25 mL E. 2 mL 71. A medication order indicates 1.5g of an antibiotic to be added to 1000 ml of D 5 W. How many mL of a 250mg/3 mL injection should be added to the D 5 W to prepare this medication order? A. 12 mL B. 15 mL C. 18 mL D. 20 mL E. 22 mL 72. In addition to the active ingredient in an oral solution, it also contain 40.5% of alcohol and 23.8% propylene glycol. Determine the quantities of the two ingredients in a 240 mL bottle of oral solution. A. 77.3 mL alcohol; 57.12 mL propylene glycol B. 97.2 mL alcohol; 67.4 propylene glycol C. 79.4 mL alcohol; 47.62 mL propylene glycol D. 97.2 mL alcohol; 57.12 mL propylene glycol E. 87.3 mL alcohol; 45.6 mL propylene glycol 73. If 240 ml of ranitidine syrup contains 2.3 g if ranitidine, how many mg of ranitidine would’ve been administered in a patient who takes 1 teastpoonful of the syrup?

C. 42.7 mg D. 51.8 mg E. 45.2 mg

74. If a pediatric patient requires a 0.02 mg dose of digoxin, what volume of an 80 mcg per mL injection should be administered? A. 0.5 mL B. 0.25 mL C. 0.75 mL D. 0.8 mL E. 1 mL 75. A patient with glaucoma brings a prescription for Alphagan P with a signa of one drop in the affected eye(s) three times daily. Alphagan P contains 0.15% brimonidine tartrate per 10 mL bottle. How many mg of brimonidine tartrate is administered daily if the patient is treat both eyes, and the dropper used delivers 20 drops per mL? A. 0.25 mg B. 0.3 mg C. 0.45 mg D. 0.55 mg E. 0.6 mg 76. A fluticasone nasal spray preparation contains 45 mcg of fluticasone propionate per actuation spray in each 100 mg formulation. How many mg of fluticasone propionate is contained in each container if each container provides 100 sprays? A. 5mg B. 3 mg C. 10 mg D. 4.5 mg E. 4 mg 77. If the normal daily dose for gentamicin is 3 mg/kg/day, and administered in three divided doses, what would be the single (8 hour) dose for a 123 lb patient and scheduled to receive 45% of the usual dose based on renal impairment? A. 32.08 mg B. 20.15 mg C. 25.16 mg D. 28.25 mg E. 75.5 mg 78. Determine how many teaspoonfuls of an oral solution should be administered to a 145-lb patient if the recommended adult dose is 0.3 mL/kg. A. 4 tsp B. 8 tsp C. 6 tsp D. 2 tsp E. 3 tsp 79. A 45-lb child has been prescribed with dimenhydrinate, where the labelled dose of the drug reads 1.3mg/kg. The available oral solution contains 12.5 mg/5 mL of dimenhydrinate. The nurse checked the hospital pharmacist if her calculated dose of 10.6 mL is correct. What would you tell her? A. Her calculations are correct. B. Her calculations are incorrect. C. Her calculations have no basis D. None of these E. All of these 80. A 145-lb patient was receiving filgrastim in doses of 10 mcg/kg/day. When the blood test results arrive, her dose was lowered to 7 mcg/kg/day. If an injection containing 0.3 mg filgrastim per 0.5 mL is used, determine the previous and new dose to be administered to this patient. A. 2 mL previous dose; 1 mL new dose B. 1.1 mL previous dose; 0.92 mL new dose C. 1.75 mL previous dose; 0.87 mL new dose D. 3.4 mL previous dose; 1 mL new dose E. 1 mL previous dose; 0.68 mL new dose 81. If the pediatric dose for an antibiotic is “7 mg/kg q 12 h”, what is the daily dose in mg for a child weighing 47 lb? A. 299 mg per day

B. 459 mg per day