Presentation on,
“MICROMERITICS”
Presented by-
Mr. Firodiya S.R. (M.Pharm,Pharmaceutics)
Assistant Professor,
Department Of Pharmaceutics
MES College of Pharmacy, Sonai.
Mula Education society’s college of pharmacy,
sonai.
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Micromeritics: Particle Size and Its Importance in Pharmacy, Slides of Pharmacokinetics
This presentation provides a comprehensive overview of micromeritics, the science and technology of small particles, focusing on its significance in pharmaceutical applications. It delves into the fundamental properties of particles, including size, shape, and surface area, and explores how these properties influence various aspects of drug formulation and delivery. The presentation also discusses different methods for determining particle size, such as optical microscopy, sieving, sedimentation, and conductivity methods, highlighting their advantages and disadvantages. This resource is valuable for students and professionals in pharmacy and related fields seeking to understand the principles of micromeritics and its practical applications in drug development.
Typology: Slides
2024/2025
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Presentation on,
“MICROMERITICS”
Presented by-
Mr. Firodiya S.R. (M.Pharm,Pharmaceutics) Assistant Professor, Department Of Pharmaceutics MES College of Pharmacy, Sonai. Mula Education society’s college of pharmacy, sonai.
Defination-
“The science and technology of small
particles is known as micromeritics.”
Fundamental properties
Individual particle.
Derived properties Derived From
Fundamental properties
Properties of powder
Fundamental properties:-
1. Particle size and size distribution
2. Particle shape
3. Particle surface area
4. Particle weight
5. Particle number
Derived properties:-
1. Density of powders
2. Flow properties of powders
3. Porosity
4. Bulkiness
Particle size determination (PSD) Methods-
1. Optical Microscopy
2. Sieving Method
3. Sedimentation Method
4. Conductivity Method
1. OPTICAL MICROSCOPY
Particle size in the range of 0.2 – 100 μm can be measured. This method gives number distribution which can be converted to weight distribution Optical microscope lens has limited resolving power Advanced microscopes have better resolving power and can measure size in nano range: Ultramicroscope, Electron microscope- Scanning Electron microscope (SEM), Transmission Electron microscope (TEM).
Application: Particle size analysis in suspensions, aerosols, globule size analysis in emulsion.
Calibrated Using A Standard Stage Micrometer.
Advantages- One can view particles Any aggregates detected Contamination of particles detected Use of cover slip for arresting motion of particles Easy and simple
Disadvantages- Length and breadth can be detected but depth or thickness of particles cannot be measured Slow- time consuming , tedious, inaccurate Number of particles to be measured is more Large sample required
Normally, 15% of fine powder should be present in granulated material to get proper flow of material and achieve good compaction. Thus percent of coarse, moderate, fine powder is estimated by this method.
METHOD OF SIEVING
- Mechanical dry sieving method
A-Agitation method (Oscillation,Vibration,Gyration) B-Brushing method C-Centrifugal method
- Wet sieving method
Method:
A sieve stack usually comprises 6-8 sieves. Powder is loaded on to the coarsest sieve of the stack and then it is subjected to mechanical vibration for specified time. After this time, the powder retained on each sieve is weighed. The particles are considered to be retained on the sieve mesh with an aperture corresponding to the sieve diameter. The size is estimated as per the standards given in pharmacopoeia.
Care should be taken to get reproducible results. The type of motion, time of operation, speed, weight of powder should be fixed and standardized.
Advantages- Inexpensive, Simple, Rapid, Reproducible results. (if parameters are standardized)
Disadvantages- lower limit is 30 microns Powder if moist, can cause clogging of apertures Attrition between particles during the process may cause size reduction giving inaccurate results.
3. Sedimentation Method