PHCY 402 - Vancomycin Study

Set Exam

polar; large - Answer vancomycin is too ___ to penetrate the outer membrane and too

___ to pass through porin channels

vancomycin (vancocin, vancoled) - Answer DOC for MRSA

PMC (c. diff super infection) - Answer vancomycin is only used orally to treat ____

true - Answer T/F: you must monitor serum levels of vancomycin to ensure efficacy and

reduce toxicity

polymerization (of the amino sugars) - Answer Beta-lactams inhibit cross-linking;

glycopeptides inhibit ____

Lipid II - Answer ____ shuttles NAG-NAM precursors to the GT enzymes that form the

growing polymer

5 (very high affinity) - Answer Vancomycin binds to Lipid II with __ hydrogen bonds

H-bond donor - Answer Vancomycin resistant mutation removes a critical ____, which

decreases binding affinity by 1000 fold

red man syndrome - Answer common side effect to vancomycin; red back/neck/face

caused by rapid histamine release into bloodstream if injected too fast

slow; antihistamines - Answer vancomycin should be given in a (slow/fast) infusion,

along with ____ every 1-2 hours

Nephrotoxicity/ototoxicity - Answer What rare side effects of vancomycin have an

increased chance when administered along with aminoglycosides?

myocardial infarction - Answer in red man syndrome, histamine --> seizures --> _________

lipid appendage - Answer lipoglycopeptides are just glycopeptides with the addition of a

_____

true - Answer T/F: the lipid appendage addition in lipoglycopeptides counters some loss

of affinity in Vancomycin-

resistant mutants with decreased H-bonding

telavancin (vibativ) - Answer lipoglycopeptide with long half life; produces detergent like

effects against cell membrane; Tx - MRSA complicated skin infections