PHYSIOLOGY 1021 MIDTERM STUDY GUIDE, Exams of Physiology

PHYSIOLOGY 1021 MIDTERM STUDY GUIDE

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PHYSIOLOGY 1021 MIDTERM STUDY GUIDE
Physiology - Answer -Study of the normal functioning of a living organism and its
component parts.
Homeostasis - Answer -The ability of the body to maintain a relatively constant internal
environment. Also, the process is dynamic and fluctuations are normal.
Negative Feedback - Answer -A primary mechanism of homeostasis, whereby a
change in a physiological variable that is being monitored triggers a response that
counteracts the initial fluctuation.
negative feedback loop - Answer -To help homeostasis, the body uses this to help
monitor and respond to changes in the internal environment.
extracellular fluid (ECF/ Interstitial fluid) - Answer -fluid outside the cell
intracellular fluid - Answer -fluid within cells
Relationship of the Cell and Extracellular fluid - Answer -Cells within our body are
surrounded by extracellular fluid which serves to act as transition between the external
environment and the intracellular fluid inside cells.
Ion composition of the inside vs outside of a cell - Answer -Salty Banana (salt on the
outside, and banana on the inside)
cell membrane (+3 functions) - Answer -A cell structure that controls which substances
can enter or leave the cell. Made up of phospholipids to form a phospolipid bilayer.
1. Physical isolation
2. Exchange with the environment
3. Communication
phospholipid molecule - Answer -fundamental repeating unit within a plasma
membrane; it has two parts---head group (polar + hydrophilic) and tail group (non-polar
+ hydrophobic).
Cell membrane proteins roles(4) - Answer -1. Ion Channels
2. Enzymes
3. Receptors
4. Membrane carriers
membrane transport (5 Methods) - Answer -1. Endo/exocytosis
-phagocytosis of small molecules
2. Diffusion through lipid bilayer
- Fat-soluble molecules
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PHYSIOLOGY 1021 MIDTERM STUDY GUIDE

Physiology - Answer - Study of the normal functioning of a living organism and its component parts. Homeostasis - Answer - The ability of the body to maintain a relatively constant internal environment. Also, the process is dynamic and fluctuations are normal. Negative Feedback - Answer - A primary mechanism of homeostasis, whereby a change in a physiological variable that is being monitored triggers a response that counteracts the initial fluctuation. negative feedback loop - Answer - To help homeostasis, the body uses this to help monitor and respond to changes in the internal environment. extracellular fluid (ECF/ Interstitial fluid) - Answer - fluid outside the cell intracellular fluid - Answer - fluid within cells Relationship of the Cell and Extracellular fluid - Answer - Cells within our body are surrounded by extracellular fluid which serves to act as transition between the external environment and the intracellular fluid inside cells. Ion composition of the inside vs outside of a cell - Answer - Salty Banana (salt on the outside, and banana on the inside) cell membrane (+3 functions) - Answer - A cell structure that controls which substances can enter or leave the cell. Made up of phospholipids to form a phospolipid bilayer.

  1. Physical isolation
  2. Exchange with the environment
  3. Communication phospholipid molecule - Answer - fundamental repeating unit within a plasma membrane; it has two parts---head group (polar + hydrophilic) and tail group (non-polar
  • hydrophobic). Cell membrane proteins roles(4) - Answer - 1. Ion Channels
  1. Enzymes
  2. Receptors
  3. Membrane carriers membrane transport (5 Methods) - Answer - 1. Endo/exocytosis
  • phagocytosis of small molecules
  1. Diffusion through lipid bilayer
  • Fat-soluble molecules
  1. Diffusion through protein channels
  • Water-soluble molecules
  1. Facilitated Diffusion
  • Large/bulky molecules
  1. Active Transport
  • Against concentration gradient simple diffusion - Answer - movement of a solute from an area of high concentration to an area of low concentration due to a molecule's random thermal motion. (Passive, no energy) Factors that affect the rate of diffusion(6) - Answer - 1) Bilayer surface area
  1. Bilayer composition
  2. Bilayer thickness
  3. Fat solubility of molecule
  4. Lipid solubility of molecule
  5. Concentration gradient Diffusion of fat-soluble molecules - Answer - ECF ( High concentration), ICF (Low concentration). A non-polar + hydrophobic (i.e Co2, O2) moves through the phospholipid bilayer and enters the cell. Diffusion of water-soluble molecules through protein channels - Answer -- Protein mediated transport
  • High concentration in ECF
  • Low concentration in ICF
  • Channel protein is positive
  • Negative ion (Ex. Chlorine, Salt (NaCL))
  • Chlorine passes through and Na leaves "Opposites attract" List 4 factors that affect the diffusion of water-soluble molecules - Answer - 1. Concentration gradient (larger=faster)
  1. Molecule size
  2. Charge of molecule
  3. Number of protein channels facilitated diffusion (carrier protein) - Answer - the movement of specific molecules across a cell membrane through protein channels. A molecule such as chlorine binds to the receptor of the carrier protein and this results in an uncomfortable state for the protein. Therefore, the protein makes a conformation change and switches to inside the cell and releases chlorine inside before returning back to its original (comfortable) state. ion channels - Answer - A transmembrane protein channel that allows a specific ion to diffuse across the membrane down its concentration or electrochemical gradient.

Calculation: = # particles/molecule x molarity Osmolarity Question: Compartments 1 and 2 are separated by a membrane that is permeable to H20 but not permeable to CaCl2 or glucose. Initially, compartment 1 contains 200mM of CalCl2 and compartment 2 contains 100mM of glucose. After osmotic equilibrium is reached. Which compartment will have increased in volume? - Answer - Compartment 1 will increase in volume C1: 200mM CaCl 3 ions per CaCl2 x 200mM = 600mOsm/L C2: 100mM Glucose 1 glucose x 100mM = 100 mOsm/L Therefore, C1 is more concentrated and H20 will move toward C1 to dilute. Osmolarity of body fluids - Answer - 300 mOsm Isotonic: same osmolarity as body fluids Hypotonic: lower Osmolarity than body fluids Hypertonic: higher osmolarity than body fluids Effect of isotonic, hypertonic and hypotnic solutions on red blood cells - Answer - Hypertonic: Water moves out (Cells shrivel) Isotonic: equal movement of water (Cells stay the same) Hypotonic: Water moves in (Cells expand) electrochemical gradient - Answer - The diffusion gradient of an ion, representing a type of potential energy that accounts for both the concentration difference of the ion across a membrane and its tendency to move relative to the membrane potential. Electrochemical equilibrium - Answer - When electrical gradient driving ion toward opposite charge <======= = Chemical gradient driving ion from high to low concentration =======> distribution of electrical charge in a cell - Answer - Resting Membrane Potential = - 70mV K+ is very permeable to leaving the cell (More inside the cell than out) Cl- Very permeable to entering cell (More outside than inside the cell) Na+ not very permeable to Na+ (More outside than in) ATP Pump 3Na+ out 2K+ in

(Salty Banana) Resting Membrane Potential - Answer - The electrical potential of a cell membrane, resulting from the unequal distribution of a few key ions across biological membranes. (All cells have RMP) Factors that affect the cell's membrane potential(2) - Answer - 1. The concentration(Ex.K+,Na+,Cl-) gradients of different ions across the membrane

  1. The permeability of the membrane to those ions Functions of Sodium/Potassium Pump and the RMP - Answer - 1. Na+ Out of the cell
  2. K+ into the cell Overall: Maintains concentration Gradients DOES NOT GENERATE RMP Excitable cells - Answer - Generate and respond to electrical signals. Note* Neurons use electrical signals(in the form of action potentials) to receive, process, initiate and transmit messages. Labeling a Neuron - Answer - Missing axon hillock+ located right before axon. Changing electrical potential - Answer - At rest the cell is slight permeable to Na+. Therefore, if we change the permeability of the cell to Na+, we can change its electrical potential! Gated channels (3 types) - Answer - Controls the ion permeability of neurons Mechanically gated ions channels: open in response to mechanical stimulation Chemically gated ion channels: open in response to a chemical binding Voltage-gated channels: open in response to a voltage change. Depolarization - Answer - The process during the action potential when sodium is rushing into the cell causing the interior to become more positive. Repolarization - Answer - Return of the cell to resting state(RMP), caused by reentry of potassium into the cell while sodium exits the cell. Threshold - Answer - The minimum depolarization that will initiate an action potential (- 55mV) Hyperpolarization - Answer - A membrane potential that is more negative than the RMP Graded Potentials - Answer - small changes in membrane potential that by themselves are insufficient to trigger an action potential. Occur in the soma or dendrites of a neuron. "Graded" because the amplitude of a potential is directly proportional to the stimulus strength.

saltatory conduction $ benefits (3) - Answer - the jumping of action potentials from node to node

  1. Less current leak
  2. Less resistance
  3. Smaller axon diameters multiple sclerosis - Answer - myelin sheath destruction. disruptions in nerve impulse conduction The Chemical Synapse (5) - Answer - 1) Depolarizing Stimulus
  4. VG Ca2+ Open, Ca2 IN
  5. Vesicles Release N.T
  6. Neurotransmitter bind to receptors
  7. Ion channels open or close Neural Signaling is short in duration - Answer - 1 - Neurotransmitters are returned to axon terminals 2 - Enzymes in synapse inactivate neurotransmitters 3 - Neurotransmitters diffuse out of the synaptic cleft excitatory postsynaptic potential (EPSP) - Answer - The action potential results in depolarization of the post-synaptic cell. Inhibitory post-synaptic potential(IPSP) - Answer - The action potential results in hyperpoloarizaiton of the post-synaptic cell. Another name for IPSP or EPSP in the post-synaptic potential - Answer - Graded potential. CNS - Central Nervous system - Answer - brain and spinal cord PNS (peripheral nervous system) - Answer -- Somatic system
  • Spinal nerves
  • Visceral System (Automatic Nervous System)
    • Parasympathetic
    • Sympathetic Organization of PNS (2) - Answer - Ganglia (Gray Matter) - Collections of neurons Nerves (White Matter) - Bundles of axons Organization of CNS - Answer - Neural Cortex( Gray Matter)- Gray matter on the surface of the brain Nuclei(Gray Matter) - Collections of the neuron cell bodies in the interior of CNS Centers (Gray Matter) - Neuron cell bodies in CNS. Higher centers are the most complex in the brain

Tracts (White Matter) - Bundles of CNS axons Columns(White Matter) - Several tracts that form an anatomically distant mass Tracts - Answer - Centers and pathways that connect the brain and other organs and systems in the body Views of the Brain(4) - Answer - 1) Dorsal (Top)

  1. Ventral (Back)
  2. Lateral (Side)
  3. Medial(Midline) anterior/posterior (Rostral and Caudal) - Answer - front and back Dorsal & Ventral - Answer - Dorsal means towards the back, Ventral means towards the front or belly. Midline - Answer - Central axis Medial - Answer - Toward the midline of the body Lateral - Answer - away from the midline (towards side) Ipsilateral - Answer - on the same side of the body Contralateral - Answer - on the opposite side of the body Planes through the brain(3) - Answer - Midsagittal (Rostral <---> Caudal) Horizontal Coronal ( Vertical cut horizontally) Parts of a brain - Answer - *Know Right/hemisphere Sagittal Fissure Cerebrum Cerebellum Brain Stem Spinal Cord Cerebrum - Cerebral Cortex - Answer -- Two cerebral hemispheres divided by the sagittal fissure(midline)
  • Concerned with contralateral sensation and movement. Cerebellum - Answer -- Two hemispheres
  • Concerned with ipsilateral motor control brain stem - Answer -- Most primitive part of the brain
  • Carry information from a place
  • Usually refers to taking motor information from the CNS, to a motor target Cranial Nerves - Answer -- In addition to the 31 pairs of spinal nerves, there are also 12 pairs of cranial nerves that come directly off the brain
  • They take care of function in the head. The Meninges - Answer - Three Meninges cover the brain and spinal cord
  1. Dura Mater "Hard mother" - thick like leather
  2. Arachnoid "Spider
  3. Pia Mater "Gentle Mother" Cerebrospinal Fluid - CSF Subarachnoid Space Ventricular System - Answer -- CSF is produced by the choroid plexus
  • Most choroid plexus is found within this system, in the brain
  • Spaces within the brain that contain CSF are called ventricles
  • This system is a series of ventricles and canals that move CSF within the brain and transport in out to the subarachnoid space.
  • Contains about 150ml of CSF
  • You product 500mL of CSF/Day Lobes of the Cerebral Cortex(4) - Answer - frontal, parietal, occipital, temporal
  • Central Sulcus runs down the middle (between Frontal and Parietal) Touch - Cutaneous Sensation (Why is touch important) - Answer -- manipulating objects
  • writing
  • knowing a bug was on you
  • sex
  • knowing something is hot
  • Most important - protecting you for injury Proprioception - Answer - The sense of limb position Kinesthesis - Answer - The sense of limb movement How is the sensory system unique? - Answer - Receptors are not concentrated into one location, like the retina or cochlea. Major Peripheral Nerves of the Human Body - Answer - Peripheral nerves terminate in either the spinal cord(spinal nerves) or brain stem(cranial nerves) Touch (2 Skin tpyes + 2 Layers) - Answer - Skin Types
  1. Hair - arm or leg
  2. Glabrous (Hairless) - Palm

Two Layers:

  1. Epidermis - Outer Layer
  2. Dermis - Inner Layer Mechnoreceptors (+ 4 Types) - Answer - Makes up most sensory receptors of the somatosensory system. Sensitive to physical distortion of the skin, such as bending or stretching. Types
  3. Merkel's disks (receptor) - disk-shaped receptor near the border of the epidermis and dermis
  4. Meissner's corpuscles - a stack of flattened cells in the dermis, just below the epidermis
  5. Ruffini's endings(cylinder) - many breached fibers within a cylindrical capsule
  6. Pacinian corpuscles - largest - a layered, onion-like capsule that surrounds a nerve fiber deep in the dermis. Adaptation Rate & Receptive Field Size(4) - Answer - Adaptation Rate - how quickly a receptor ceases to fire with ongoing input. (How fast they get used to the presence of the stimulus) Receptive Field Size - The area of skin which, when stimulated influences the firing rate of a given neuron
  7. Merkel's Disk (Slow Adaptation and Small receptive fields)
  8. Meissner's Coruscle (Rapid adaptation and small receptive fields)
  9. Ruffini's Endings (Large Receptive Field & Slow adaptation)
  10. Pacinian Corpuscle (Rapid Adaptation and Large Receptive Fields) Thermoreceptors - Answer - respond to changes in temperature Tactile acuity - Answer - Measured on the body surface by measuring two-point discrimination- the smallest separation between two points on the skin that is perceived as two points rather than one. (Higher tactile acuity= small receptive fields). Dermatomes - Answer - an area of the skin supplied by nerves from a single spinal root.
  • Somatosensory cortex(1,2,3a,3b)
  • Posterior parietal cortex (5,7)

Three factors

  1. The stimulus
  2. The eye
  3. The central visual pathways Snellen Acuity - Answer - Measurement of detail resolved at 20 ft relative to the distance at which a normal observer can resolve the same detail. 20/ 20/40 ( You can see like normal people at 40ft) 20/15 you can see like normal people at 15 ft Legal blindness 20/ eye anatomy(7) - Answer - Pupil - Hole in center Iris - Color of your eye, regulates size of pupil Cornea - Clear sheet in front of the pupil and iris Sclera - The white in your eye, and majority of the eyeball Conjunctiva - inside of eyelid Extra ocular Eye muscles Optic nerve retina anatomy (5 cell types) - Answer - photoreceptors(1) to bipolar(2) to ganglion cells(3) horizontal(4) and amacrine(5) cells modify this pathway cells in layers 125 million photoreceptors nuclear layers (Part of Retinal Layers) - Answer - where the cell bodies are Plexiform layers (6)(Part of Retinal Layers) - Answer - Where the synapses and axons are
  1. Ganglion cell layer
  2. Inner Plexiform Layer
  3. Inner Nuclear layer
  4. Outer Plexiform Layer
  5. Outer Nuclear Layer
  6. Photorecepptor Outer Segments The Retina (3 Important Points) - Answer - 1) The retina is a sheet of several layers of cells that lies against the posterior (back) wall of the eye.
  1. The retina is set up backwards to the way that wuould expect it to be.
  2. A pigment epithelium lines the back of the retina, against the photoreceptors. pigment epithelium - Answer - most posterior part of retina; absorbs stray light so visual image is not degraded.

Photoreceptors (2 Type + Parts) - Answer - Two Major Parts:

  1. Outer segment - the photosensitive part
  2. Inner segment - contains cell body Two Types:
  3. Rods
  • Light sensitive and used during dim lighting conditions - scotopic vision (Darkness)
  1. Cones
  • Color sensitive and used during daylight conditions - photopic vision (Bright) Rods and Cones - Answer -- Nasal retina is physically larger than temporal retina and contains the blind spot (no photoreceptors)
  • Fovea contains only cones. (Splits the nasal and temporal)
  • 5 million cones in each retina
  • 120 million rods in each retina Distribution of rods and cones - Answer -- Uneven distribution
  • In the periphery, rods outnumber cones (20:1)
  • Cones are concentrated in central vision (fovea) - in fact, the fovea contains no rods.
  • Cones are concentrated in central vision (fovea) - Fovea has no rods
  • Rods are concentrated in peripheral vision
  • No photoreceptors can be found in optic disk blind spot (optic disc) - Answer - Receptors are on the back wall of the eye, and block ganglion cells axons from leaving the eye. Blind spot - area devoid of receptors Where 1 million ganglion cell axons leave the eye to form the optic nerve. We aren't aware of the blind spot because the brain fills it in. macula - Answer - The center of the visual field The fovea - Answer - Pit with the ganglion and bipolar cells pushed to the side, so that the light has an easier time striking the photoreceptors. Phototransduction - Answer - Light into electricity. The photoreceptor outer segment is where light acts to create electricity. Cone and Rod Types (4) - Answer - Blue cones Green Cones Red Cones 1 Type of Rod
  • 2 - 3 mm thick
  • V1 is the first place in the brain where cells receive signals from both eyes Information Processing in V1 - Answer - Neurons are specialized to respond best to specific aspects of stimuli, such as orientation, movement and size. These specializations can be demonstrated physiologically, by recording from neurons. V1 Physiology - Answer - Hubel and Wisel
  • Spots of light stimulate ganglion cells
  • Spots of light do little to stimulate neurons in V
  • Sliding a slit of light across the visual field caused neurons to discharge.
  • They found that V1 neurons respond best to bar-like stimuli with specific orientations. V1 Neurons - Answer -- Cortical neurons fire in response to specific feature of the stimulus, such as orientation or direction of motion.
  • Therefore, these neurons are called feature detectors.
  • As we move farther from the retina, neurons will be found to only respond to more complex stimuli Parallel Processing Streams in Visual Cortex - Answer -- Dorsal Stream "Where" or How pathway Parietal Cortex Spatial analysis Motion Visual Control of Movement
  • Ventral Stream "What" pathway Temporal Cortex Object and Pattern Identification Functions of Hearing(3) - Answer - 1) Communication - speech and music
  1. Danger - smoke detector
  2. Help - crying baby Sound - Answer - Variation in air pressure Frequency (pitch) - Answer - The number of compressed air patches (Hertz/Hz) - # of cycles/second Intensity (loudness) - Answer - The difference in pressure between compressed air patches (amplitude) Volume. Decibel - Answer - Unit used to express amplitude (loudness). Named after Alexander Graham Bell, the decibel scale is logarithmic.

The Range of Hearing (Humans) - Answer - 20 - 20,000 Hz The Audibility Curve - Answer - Indicates how sensitivity changes across the frequencies that we can hear by plotting the threshold for hearing versus frequency. Most sensitive between 2,000 and 4,000Hz. Structure of the Auditory System (3) - Answer - 1. Outer Ear

  • Auricle (Pinna) - Moveable in some animals
  • Auditory Canal (External Auditory Meatus)
  1. Middle Ear
  • Tympanic membrane (ear drum)
  • Ossicles (Three small bones)
  1. Inner Ear
  • Oval Window
  • Cochlea The Auditory Canal - Answer - Protects ear drum. Enhances the intensities of sound by means of resonance. Resonance - Answer - A mechanism that enhances the intensity of certain frequencies because of the reflection of sound waves in a closed tube. Resonant Frequency - Answer - Frequency that is most intesified/ Determined by the length of the tube. These frequencies are between 2,000 and 5,000 Hz in humans. The Middle Ear (4) - Answer - 1) Malleus (Hammer)
  1. Incus (anvil)
  2. Stapes (Sitrrup) Auditory Tube (Eustachian Tube) - An airway between the middle ear and the pharynx. - important in changing air pressure. Why are the ossicles necessary? - Answer - Because sound vibrations are ineffective for moving a fluid. The ossicles amplify the force exerted against the oval window and convert air pressure changes into mechanical pressure. The fluid-filled cochlea presents a challenge - Answer - Outer Ear- Filled with Air Middle Ear- Filled with Air Inner Ear - Filled with cochlear. The ossicles have to convert air vibration into fluid vibration. Pressure changes in the air are transmitted poorly to the much denser liquid.

How do signals get out of the cochlea? - Answer -- Hair cells synpase with spiral ganglion cells. The cell bodies of these neurons are located in the spiral gaglion. The axons of these neurons form the auditory portion of the Vestibulocohlear Nerve. (Cranial Nerve 3). Therefore, spiral ganglion cells are similar to retinal ganglion cells(The output neurons.) Deafness - Answer -- Destruction of auditory cortex in one hemisphere does not result in the loss of hearing on one side. (Because inpuit from both ears goes to each hemisphere)

  • It does result in a loss of the ability to localize sound in the opposite hemifield
  • More hearing loss is due to death(with age) or destruction (loud noise) of hair cells
  • Unfortunately, hair cells do not regenerate. Hormone - Answer - A chemical signal secreted into the blood to act on a distant tissue. Produced in glands OR in cells of an organ. Endocrine Tissues: (4) - Answer - Pituitary: Oxytocin Antidiuretic hormone + other hormones Pancreas: Inslulin and Glucagon Hypothalamus: Various Hormones Thyroid: T3,T Adrenals: Epinephrine, Cortisol, Aldosterone Steroid Hormones - Answer - Ex. Testosterone, estrogen, cortisol Cholesterol is the building block and these are hydrophobic. Protein or Peptide Hormones - Answer - Ex. Hypothalamic and pituitary hormones Amino acids are the building blocks and these are hydrophilic hormones. Amines - Answer - Ex. Catecholamines (epinephrine), Thyroid hormones (T3,T4) Tyrosine is the building block and these can be either hydrophilic(Epinephrine) or hydrophobic(Thyroid Hormones). Labeling Hypothalamus, infundibulum, and Pituitary Gland - Answer - Hypothalamus Infundibulum Pituitary: Anterior Posterior Hormones: Posterior Pituitary - Answer - Oxytocin: A peptide neurohormone
  • Promotes uterine contractions
  • Promotes milk excretion Antidiuretic Hormone (ADH): Also a peptide neurohormone
  • Promotes water reabsorption in kidneys