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Significant words, quotes, and summaries from the first problem set of Jay Phelan's Life Science 15 course at UCLA. Full questions and complete answers for the problem set, with quotes that cite chapter 1 in What Is Life?A Guide to Biology with Physiology by Phelan, Jay;
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Biology: the study of living things General scientific literacy: a general, evidence-based understanding of the basics of biology and other sciences Biological literacy: the ability to (1) use the process of scientific inquiry to think creatively about real- world issues that have a biological component, (2) communicate these thoughts to others, and (3) integrate these ideas into your decision-making. Empirical: empirical knowledge is based on experience and observations that are rational, testable, and repeatable. Hypothesis: a proposed explanation for an observed phenomenon ● It must establish an alternative explanation for a phenomenon. That is, it must be clear that if the proposed explanation is not supported by evidence or further observations, a different hypothesis is a more likely explanation. ● It must generate testable predictions. This characteristic is important because we can evaluate the validity of a hypothesis only by putting it to the test. This is, in fact, how science commonly advances: we disprove hypotheses, which serves to increase our confidence in alternative explanations. For example, we could disprove the “Eyewitness testimony is always accurate” hypothesis by demonstrating that, in certain circumstances, individuals who have witnessed a crime might misidentify the criminal. ● It is impossible to prove that a hypothesis is absolutely and permanently true : all evidence or further observations that support a hypothesis are valuable, but future evidence might show that the hypothesis is not true. Null hypothesis: A hypothesis that states a lack of relationship between two factors ● Example: Echinacea has no effect on the likelihood of catching a cold or the duration of cold symptoms. Testable prediction: to propose a situation that will give a particular outcome if our hypothesis is true, but will give a different outcome if our hypothesis is not true. ● Generally phrased in “If that is true… then I would expect” structure Critical experiment: “an experiment that makes it possible to decisively determine whether a particular hypothesis is better than the alternative hypotheses.” Treatment: any experimental condition applied to the research participants. It might be the pattern used to show “suspects” (all at once or one at a time) to the witness of a staged crime, or the dosage of echinacea given to an individual.
Experimental group: a group of research participants who are exposed to a particular treatment—for example, the individuals given echinacea rather than a placebo in the experiment described earlier. It is sometimes referred to as the “treatment group.” Control group: a group of research participants who are treated identically to the experimental group, with one exception—they are not exposed to the treatment. An example would be the individuals given a placebo rather than echinacea. Variables: the characteristics of an experimental system that are subject to change. In an experiment, the variables can be described as either independent or dependent. ● An independent variable is some entity that can be observed and measured at the start of a process, and whose value can be changed as required. As an example, the independent variable might be the amount of echinacea a person is given. ● A dependent variable is one that can also be observed and measured, but whose response is created by the process being observed and depends on the independent variable. A dependent variable in the echinacea study might be how long the symptoms of a cold last. Placebo Effect: This is the frequently observed, but poorly understood, phenomenon in which people respond favorably to any treatment. The placebo effect amplifies the need for an appropriate control group. Blind Experimental Design: withhold from a participant any information that may influence him or her. ● Double-blind experiment: neither the experimental participants nor the experimenter knows which treatment a participant is (or may be) receiving. Randomized: researchers and research participants have no influence on the composition of the two groups Replication: the process of repeating a study. Scientific theory: an explanatory hypothesis for natural phenomena that is exceptionally well supported by empirical data. Pseudoscience: in which individuals make scientific-sounding claims that are not supported by trustworthy, methodical scientific studies Anecdotal observations: in which, based on just one or a few observations, people conclude that there is or is not a link between two things Characteristics shared by all living organisms and living systems:
1.8: “To draw clear conclusions from experiments, control and experimental groups should differ only with respect to the treatment of interest. Differences in outcomes between the groups can then be attributed to the treatment.” 1.9: “Evidence gained from well-controlled studies designed in accordance with good scientific thinking can illuminate when we should change our minds. We make choices every day based on assumptions about our world; it is essential to question these choices and the veracity of our assumptions.” 1.10: “Biases can influence our behavior, including our collection and interpretation of data. With careful controls, it is possible to reduce the impact of biases.” 1.11: “Scientific theories do not represent casual guesses about the natural world. Rather, they are hypotheses—proposed explanations for natural phenomena—that have been so strongly and persuasively supported by empirical observation that the scientific community views them as very unlikely to be altered by new evidence.” 1.12: “Visual displays of data can aid in the presentation and exploration of the data. Their effectiveness is influenced by the precision and clarity of the presentation, and can be reduced by ambiguity, biases, hidden assumptions, and other issues that reduce a viewer’s confidence in the underlying truth of the presented results.” 1.13: “Statistics can help us evaluate whether any differences between a treatment group and a control group can be attributed to the treatment rather than chance.” 1.14: “Pseudoscience and anecdotal observations often lead people to believe that links between two phenomena exist, when in fact there are no such links.” 1.15: “Although scientific thinking is an effective path toward understanding the observable world, it cannot give us insights into value judgments and other nonquantifiable, subjective information.” 1.16: “Life” is not easily described with a simple definition, but rather is identified by the presence of certain characteristics shared by living organisms. Although the field of biology is broad, five organizing themes are important in unifying the diverse topics.”
participate in an invasive “placebo surgery.” This consent from individuals allows us to have ethical and accurate results from willing subjects. “
2. How did the researchers decide whether the arthroscopic surgery was effective? “The researchers evaluated the effectiveness of the surgery at seven points over the next two years. The evaluations included patients’ self-reports of knee pain and body pain and researchers’ measurements of knee function. Context: The general approach that the researchers took was straightforward. In a large group of volunteers who suffered from osteoarthritis of the knee, some received arthroscopic surgery, while others received a placebo surgery. The researchers then evaluated individuals’ knee function and pain relief.” 3. What were the researchers’ results? What conclusions can you draw from these results? “At no point following surgery was pain reduced or knee function improved in patients receiving either type of arthroscopic surgery relative to those undergoing the placebo surgery. The study—which was published in the New England Journal of Medicine—provided strong evidence that arthroscopic lavage with or without debridement is not better than a placebo procedure in improving knee pain and self-reported function.” 4. Humans have been making observations and formulating hypotheses about the nature of their world for a very long time. What additional element did the scientific method add that made it such a revolutionary advancement? The scientific method (or scientific thinking) is significant because it tells us when to change our minds about the natural world. Scientific thinking is flexible, non-linear, and self-correcting. If an initial hypothesis is disproven, it encourages further experimentation and adjustments to improve future results. It takes a small, niche, trivial, or silly question and transforms it into a field of testable hypotheses that expands our perspective of the world. 5. People sometimes say that you can never definitively prove a hypothesis to be true, but that you can prove that a hypothesis is not true. How can this be? Is this a weakness of scientific thinking? Why or why not? If we can’t prove a hypothesis to be true, does that mean that all hypotheses are equally likely to be true or not true? The reason it is said that it is not possible to prove a hypothesis as definitely true is because of a variety of factors that limit the aspect of “certainty” in a hypothesis. It is not possible for a scientist to test all possibilities that can prove a hypothesis is false, so there is a chance that an exception exists that hasn’t been tested yet. Similarly, many hypotheses have cases that differ from the norm, instances where the result doesn’t exactly align with the prediction. This can also contribute to random statistical improbabilities, where the result of the hypothesis was a statistical anomaly, even if there were a lot of test cases. However, this minor limitation isn’t particularly a “weakness” of scientific thinking because repetition of predictable results leads to a large confidence level of a hypothesis being true. When a
particular belief about the natural world - but that you do not know the basis or actual truth of. Answers will vary! I suffer from ingrown eyelashes, and I was recommended to use a classic eyelash curler every day to fix the shape of my eyelashes. I have routinely been using these eyelash curlers, but I have not seen scientific evidence that eyelash curlers work in the long term. Information from: What Is Life? A Guide to Biology with Physiology Phelan, Jay; https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewBook?id= This material may be protected by copyright.