Neural Communication & Sensory Perception: Examining Neurons, Glial Cells, Myelin - Prof. , Study notes of Psychology

An in-depth exploration of neural communication, focusing on neurons, glial cells, myelin sheath, action potentials, neurotransmitters, and sensory perception. Topics include the structure and functions of neurons and glial cells, the role of myelin sheath in nerve conduction, the generation and transmission of action potentials, the mechanisms of neurotransmitter release and reception, and the sensory systems involved in sensation and perception. Students may find this document useful for understanding the fundamental concepts of neurobiology and sensory physiology.

Typology: Study notes

2011/2012

Uploaded on 03/07/2012

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I. Neural Communication
a. Neuron: nerve cells (100 billion connects with +10-100 thousand)
b. Glial cells: support, myelin, waste-clearing
i. More glial than neuron and ratio of glial to neuron dictates biological
complexity
ii. Resting potential: -70 MV inside axon
c. Myelin Sheath: fatty tissue encasing axon
d. Node of Ranvier: space between myelin sheath -> creates high sodium levels
i. Ion pumps located in nodes
e. Action potentials: limited in how fast things can go
i. Refractory period: 1-2 milliseconds
ii. All or None transmission
iii. Action potential comes down, signals to vesicles to make way to edge of
neuron
1. They then fuse w/ plasma membrane
2. Neurotransmitter: released to synaptic cleft
3. Hook up to receivers
4. Neurotransmitters determine speed of response b/c depends on # of
synaptic gaps
f. Neurotransmitters
i. NT binds to receptor
ii. Ion channels open
iii. EPSP (excitatory postsynaptic potential)
1. Dopamine [+ions into cell]
iv. IPSP (inhibitory postsynaptic potential)
1. Gabba [- ions into cell, +ions out of cell]
a. Potential: message
b. Opens another ion channel
c. If it meets a threshold?
i. Fire another AP!
v. Adding of EPSPs and IPSPs: summation
1. Temporal summation: must be close in time
2. Spatial summation: must be close in area
a. Resting: -70
II. Sensation and Perception
a. Sensation: intake of raw info into brain (low level)
b. Perception: organization and interpretation of sensory input (high level)
i. Stimulus energy -> sensory receptors -> neural impulses -> brain
ii. Sensation --------------------------------- perception-------------|
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I. Neural Communication a. Neuron: nerve cells (100 billion connects with +10-100 thousand) b. Glial cells: support, myelin, waste-clearing i. More glial than neuron and ratio of glial to neuron dictates biological complexity ii. Resting potential: -70 MV inside axon c. Myelin Sheath: fatty tissue encasing axon d. Node of Ranvier: space between myelin sheath -> creates high sodium levels i. Ion pumps located in nodes e. Action potentials: limited in how fast things can go i. Refractory period: 1-2 milliseconds ii. All or None transmission iii. Action potential comes down, signals to vesicles to make way to edge of neuron

  1. They then fuse w/ plasma membrane
  2. Neurotransmitter: released to synaptic cleft
  3. Hook up to receivers
  4. Neurotransmitters determine speed of response b/c depends on # of synaptic gaps f. Neurotransmitters i. NT binds to receptor ii. Ion channels open iii. EPSP (excitatory postsynaptic potential)
  5. Dopamine [+ions into cell] iv. IPSP (inhibitory postsynaptic potential)
  6. Gabba [- ions into cell, +ions out of cell] a. Potential: message b. Opens another ion channel c. If it meets a threshold? i. Fire another AP! v. Adding of EPSPs and IPSPs: summation
  7. Temporal summation: must be close in time
  8. Spatial summation: must be close in area a. Resting: - II. Sensation and Perception a. Sensation: intake of raw info into brain (low level) b. Perception: organization and interpretation of sensory input (high level) i. Stimulus energy -> sensory receptors -> neural impulses -> brain ii. Sensation --------------------------------- perception-------------|

c. Direct Realism (aka naïve realism) i. 1 to 1 relationship between physical and mental words: FALSE ii. After image: formed after focusing on image, makes you see weirdly colored pic iii. Physically diff things must be perceived as different: FALSE

  1. Metamerism: matching of apparent color given diff physical characteristics iv. Physically identical things must be perceived as identical: FALSE
  2. Chromatic induction: in a given context d. We perceive the world indirectly i. Filtered through sensory systems and info is tweaked e. Bottom-up processing i. Processing based on environmental stimuli
  3. To build up from lower level stim to make object; not just raw characteristics f. Top-down processing i. Processing based on existing knowledge, expectations, ect. ii. Needs context III. Vision a. Eyes: primary purpose i. Direct light to form image on back of eye ii. Transform physical energy to neural energy => transduction b. Eye function i. Lens was developed over hundreds of generations ii. In time lens redirected more light to retina c. Eye spot: i. Primitive ii. Crude sensation of light d. Pinhole eyes (possibly evolved from lightspot) i. Adjustable aperture e. Lensed eyes i. Better refraction ii. Better image formation iii. Crystalline lens
  4. Accommodation: adjustable focus IV. The human eye a. Cornea: transparent outer layer b. Pupil: regulates amt. of light entering eye i. Expand when see something we like or ‘catches our eyes’ ii. Expand when exposed to stimuli that were previously seen c. Retina:
  1. Reading braille b. Proprioception: sense of own body’s position i. Introceptive sense: internal to you ii. Ian Waterman: loss of proprioception II. Bits and Pieces a. The skin is largest organ b. Exteroceptive sense c. Types of receptors i. 4 mechanoreceptors (in order of depth)
  2. Meissner corpuscles- found in lips/genitalia/eyelids/palm a. Specialization: light touch/fine details b. Fast adapting
  3. Merkel disk- between epidermis and dermis, highly concentrated (4-10 receptors) a. Specialization: low frequency vibrations b. Slow adapting => stimulus must be present
  4. Ruffini endings- deeper in dermis, high level of neural convergence, improves sensitivity a. Specialization: lateral skin stretching b. Slow adapting
  5. Pacinian Corpuscles- deepest in dermis, poor spatial resolution a. Specialization: high frequency vibrations b. Fast adapting ii. Thermoreceptors: spread throughout body near skin
  6. Can code changes in relative and absolute temperature a. Fastest between 15-30o^ and +36o^ C i. When between 15-30o^ C, cold thermoreceptors increase firing ii. +36o^ C, warm thermoreceptors increase firing iii. Nocioreceptors: anywhere pain can be felt (none in brain)
  7. Types a. Thermal: protects against burning/freezing i. Kick in once temp goes outside 15-40o^ C b. Mechanical: excess pressure/respond to cuts in skin i. Respond to excess pressure (hitting hand in door) and tearing of skin c. Chemical: respond to ‘spices’ i. Reacts to chems that could heart you like capsasienum (peppers) d. Sleeping/silent: respond only once injury has occurred
  8. Location: anywhere pain can be felt

a. Cornea has one of highest concentrations of nocioreceptors

  1. Nerve endings a. A-Nerve endings: sharp pain i. Faster b. C-Nerve endings: dull pain i. Slower
  2. Fun fact: anesthesia works because it stops nocioreceptors from firing d. Tactile Activity: 2-point threshold i. Minimum distance between 2 points required to feel 2 points of pressure versus 1 point ii. Low threshold = high acuity
  3. Small receptive field e. Somatosensory Cortex i. Touch center of cortex ii. Parietal lobe: map of whole body iii. Phantom Limb Syndrome
  4. Phantom limbs hurt! a. Axons which used to reach end of limb end still fire b. Mirror therapy- i. Put mirror against existing limb and see how phantom limb would move iv. Haptic Tech: touch system that interfaces a machine w/ human
  5. Video games w/ rumble pack Chemical Senses I. Chemical Senses? a. Type of stimulus determines sense type i. Vision -> light ii. Hearing -> vibration iii. Touch -> pressure
  6. All energy
  7. Smell and taste stimuli come from matter/chemicals b. Function: gatekeeping between our inner body and environment i. Brings in nutrients, keeps out toxins ii. Super tasters taste things at extreme level, so some foods are really bitter and gross to them
  8. But some food is still bitter and good for you iii. Proximity to:

i. Can be specific but generally applies to everything b. Causes: i. Congenital, infection, nerve damage c. Won’t be able to taste food as much

  1. Conditioned Taste Aversion a. Discovered by John Garcia i. Radioactivity w/ rats 1. US- unconditioned stimulus
  2. Primary evolutionary function of smell has to do with regulating nutrition III. Auditory Perception a. Sound: mechanical disturbance from state of equilibrium that propagates through an elastic medium i. Cannot ravel w/out material medium
  3. No sound in vacuum
  4. Sound is vibration that causes disturbance in medium and travels at some speed a. Air: 343 m/s b. Water: 1,500 m/s c. Solid: 5,930 m/s ii. Physical dimensions:
  5. Amplitude: mag. of displacement of sound pressure wave (measured in decibels)
  6. Period/cycle: time for one cycle to occur
  7. Frequency: # of cycles per unit time a. Cycles per second: Hertz iii. Pure tone: rare in nature, sound w/ energy @ single frequency iv. Complex tone: sound with energy @multiple frequencies Illness (US) Illness (US) Nausea (UR) Nausea (UR) Food (CS) Food (CS) Nausea (CR) Nausea (CR)

b. Psychological def. of sound: sensation perceived by the sense of hearing i. Audible human range: 20-20,00 Hz ii. Max sensitivity: 3,000-4,000 Hz (human voice)

  1. We don’t sense everything. iii. Loudness: related to intensity (amplitude) iv. Pitch: related to frequency v. Timbre: related to complexity of sound
  2. 2 sounds identical in loudness/pitch but perceptively do not match in timbre a. Spectra: richness of sound b. Envelope: dynamics of sound c. Physiology of Audition i. Outer ear: Pinnae and ear canal amplify sound
  3. Pinnae : collects sounds, amplifies by 10 dB
  4. Sound waves tunneled by pinnae into ear canal a. Canal protects ear drum ii. Middle ear: transforms sound waves into mechanical vibrations
  5. Sounds hit Tympanic Membrane (ear drum) and displace the ossicles a. The ossicles: i. Transform sound waves into vibrations ii. Amplify sounds iii. Transmit sounds from air to inner ear iv. Consists of the Malleus, Incus, and Stapes iii. Inner ear: cochlea: location of auditory transduction
  6. Changes it to neural energy
  7. Cochlea: a. Filled w/ liquid b. When set in motion, stimulates hair cells which transduce mech. energy to neural energy c. Tonotopic tuning of cochlea: diff areas in cochlea encode diff frequencies i. High frequencies: maximally sensitive near base ii. Low frequencies: maximally sensitive near apex/end
  8. low frequencies travel further d. Sound in 3D world i. Distance: close-far ii. Elevation: up-down iii. Azimuth: left-right