






Study with the several resources on Docsity
Earn points by helping other students or get them with a premium plan
Prepare for your exams
Study with the several resources on Docsity
Earn points to download
Earn points by helping other students or get them with a premium plan
The role of enzymes as catalysts in protein function, focusing on catalysis, enzyme-substrate binding, and kinetic curves. Topics include michaelis-menten equations, catalytic efficiency, and various types of inhibitors. The document also delves into specific catalytic mechanisms such as acid-base and covalent catalysis, using chymotrypsin as an example.
Typology: Study notes
1 / 11
This page cannot be seen from the preview
Don't miss anything!







(^) (Ch 8-9)
(^) Wed 2/25/
Enzymes = catalysts, amazing rate enhancements! No change in equilibrium
Enzymes stabilize transition state
Michaelis-Menten kinetic equations/curves MK , V max =k cat [E] tot
catk /K M -- catalytic efficiency
“perfect
” (^) enzymes -- diffusion limit
Inhibitors Competitive, uncompetitive, noncompetitive:
max
Transition state analogs, Irreversible inhibitors
Chemistry -- specific mechanisms Chymotrypsin example - deducing mechanismsGeneral acid-base; covalent catalysis