Protein Function: Understanding Catalysis and Enzyme Kinetics, Study notes of Chemistry

The role of enzymes as catalysts in protein function, focusing on catalysis, enzyme-substrate binding, and kinetic curves. Topics include michaelis-menten equations, catalytic efficiency, and various types of inhibitors. The document also delves into specific catalytic mechanisms such as acid-base and covalent catalysis, using chymotrypsin as an example.

Typology: Study notes

Pre 2010

Uploaded on 09/17/2009

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Protein Function - catalysis (Ch 8-9) Wed 2/25/09
Enzymes = catalysts, amazing rate enhancements!
No change in equilibrium
How?
Binding (general), chemistry (specific)
Enzymes bind substrate - kinetic curves - maximal velocity
Enzymes stabilize transition state
Michaelis-Menten kinetic equations/curves
KM, Vmax=kcat[E]tot
kcat/KM -- catalytic efficiency
perfect enzymes -- diffusion limit
Inhibitors
Competitive, uncompetitive, noncompetitive: KM, Vmax
Transition state analogs, Irreversible inhibitors
Chemistry -- specific mechanisms
General acid-base; covalent catalysis
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Protein Function - catalysis

(^) (Ch 8-9)

(^) Wed 2/25/

Enzymes = catalysts, amazing rate enhancements! No change in equilibrium

  • Binding (general), chemistry (specific)How? Enzymes bind substrate - kinetic curves - maximal velocity

Enzymes stabilize transition state

Michaelis-Menten kinetic equations/curves MK , V max =k cat [E] tot

catk /K M -- catalytic efficiency

“perfect

” (^) enzymes -- diffusion limit

Inhibitors Competitive, uncompetitive, noncompetitive:

MK^

, V

max

Transition state analogs, Irreversible inhibitors

Chemistry -- specific mechanisms Chymotrypsin example - deducing mechanismsGeneral acid-base; covalent catalysis