Download Safety Data Sheet for Ethyl and Diethyl Ether by Alfa Aesar and more Study Guides, Projects, Research Engineering in PDF only on Docsity!
Creation Date 15-Apr-2009 Revision Date 18-Jan-2021 Revision Number 2
SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE
COMPANY/UNDERTAKING
1.1. Product identifier Product Description: Diethyl ether, anhydrous, ACS Cat No. : 16767 Synonyms Ethyl ether; Ether CAS-No 60-29- EC-No. 200-467- Molecular Formula C4 H10 O Reach Registration Number - 1.2. Relevant identified uses of the substance or mixture and uses advised against Recommended Use Laboratory chemicals. Uses advised against No Information available 1.3. Details of the supplier of the safety data sheet E-mail address [email protected] www.alfa.com Product Safety Department 1.4. Emergency telephone number Call Carechem 24 at +44 (0) 1865 407333 (English only); +44 (0) 1235 239670 (Multi-language)
SECTION 2: HAZARDS IDENTIFICATION
2.1. Classification of the substance or mixture Company Alfa Aesar Avocado Research Chemicals, Ltd. Shore Road Port of Heysham Industrial Park Heysham, Lancashire LA3 2XY United Kingdom Office Tel: +44 (0) 1524 850506 Office Fax: +44 (0) 1524 850608
CLP Classification - Regulation (EC) No 1272/ Physical hazards Flammable liquids Category 1 (H224)
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Diethyl ether, anhydrous, ACS Revision Date 18-Jan- Full text of Hazard Statements: see section 16 2.2. Label elements Signal Word Danger Hazard Statements H224 - Extremely flammable liquid and vapor H302 - Harmful if swallowed H336 - May cause drowsiness or dizziness EUH019 - May form explosive peroxides EUH066 - Repeated exposure may cause skin dryness or cracking Precautionary Statements P240 - Ground and bond container and receiving equipment P243 - Take action to prevent static discharges P210 - Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking P233 - Keep container tightly closed P261 - Avoid breathing dust/fume/gas/mist/vapors/spray P301 + P312 - IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell P403 + P235 - Store in a well-ventilated place. Keep cool 2.3. Other hazards Substance is not considered persistent, bioaccumulative and toxic (PBT) / very persistent and very bioaccumulative (vPvB) Toxic to terrestrial vertebrates
SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS
3.1. Substances Component CAS-No EC-No. Weight % CLP Classification - Regulation (EC) No 1272/ Ethyl ether 60-29-7 EEC No. 200-467-2 >95 Flam. Liq. 1 (H224) Acute Tox. 4 (H302) STOT SE 3 (H336) (EUH019) (EUH066) Health hazards Acute oral toxicity Category 4 (H302) Specific target organ toxicity - (single exposure) Category 3 (H336) Environmental hazards Based on available data, the classification criteria are not met
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Diethyl ether, anhydrous, ACS Revision Date 18-Jan-
SECTION 6: ACCIDENTAL RELEASE MEASURES
6.1. Personal precautions, protective equipment and emergency procedures Use personal protective equipment as required. Remove all sources of ignition. Take precautionary measures against static discharges. Avoid contact with skin, eyes or clothing. 6.2. Environmental precautions Should not be released into the environment. See Section 12 for additional Ecological Information. 6.3. Methods and material for containment and cleaning up Remove all sources of ignition. Soak up with inert absorbent material. Take precautionary measures against static discharges. Keep in suitable, closed containers for disposal. Use spark-proof tools and explosion-proof equipment. 6.4. Reference to other sections Refer to protective measures listed in Sections 8 and 13.
SECTION 7: HANDLING AND STORAGE
7.1. Precautions for safe handling Wear personal protective equipment/face protection. Handle under an inert atmosphere. Ensure adequate ventilation. Avoid contact with skin, eyes or clothing. Do not breathe mist/vapors/spray. Keep away from open flames, hot surfaces and sources of ignition. If peroxide formation is suspected, do not open or move container. Use only non-sparking tools. Use spark-proof tools and explosion-proof equipment. Take precautionary measures against static discharges. To avoid ignition of vapors by static electricity discharge, all metal parts of the equipment must be grounded. Hygiene Measures Handle in accordance with good industrial hygiene and safety practice. Keep away from food, drink and animal feeding stuffs. Do not eat, drink or smoke when using this product. Remove and wash contaminated clothing and gloves, including the inside, before re-use. Wash hands before breaks and after work. 7.2. Conditions for safe storage, including any incompatibilities Flammables area. Store under an inert atmosphere. Keep away from open flames, hot surfaces and sources of ignition. May form explosive peroxides. Containers should be dated when opened and tested periodically for the presence of peroxides. Should crystals form in a peroxidizable liquid, peroxidation may have occurred and the product should be considered extremely dangerous. In this instance, the container should only be opened remotely by professionals. Keep away from heat, sparks and flame. Keep container tightly closed in a dry and well-ventilated place. Technical Rules for Hazardous Substances (TRGS) 510 Storage Class (LGK) (Germany) Class 3 7.3. Specific end use(s) Use in laboratories
SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1. Control parameters
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Exposure limits List source(s): EU - Commission Directive (EU) 2019/1831 of 24 October 2019 establishing a fifth list of indicative occupational exposure limit values pursuant to Council Directive 98/24/EC and amending Commission Directive 2000/39/EC UK - EH40/
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Diethyl ether, anhydrous, ACS Revision Date 18-Jan- Work Exposure Limits, Third edition. Published 2018. IRE - 2018 Code of Practice for the Chemical Agents Regulations, Schedule
- Published by the Health and Safety Authority Component The United Kingdom European Union Ireland Ethyl ether STEL: 200 ppm 15 min STEL: 620 mg/m^3 15 min TWA: 100 ppm 8 hr TWA: 310 mg/m^3 8 hr TWA: 100 ppm (8h) TWA: 308 mg/m^3 (8h) STEL: 200 ppm (15min) STEL: 616 mg/m^3 (15min) TWA: 100 ppm 8 hr. TWA: 308 mg/m^3 8 hr. STEL: 200 ppm 15 min STEL: 616 mg/m^3 15 min Biological limit values This product, as supplied, does not contain any hazardous materials with biological limits established by the region specific regulatory bodies Monitoring methods BS EN 14042:2003 Title Identifier: Workplace atmospheres. Guide for the application and use of procedures for the assessment of exposure to chemical and biological agents. MDHS70 General methods for sampling airborne gases and vapours MDHS 88 Volatile organic compounds in air. Laboratory method using diffusive samplers, solvent desorption and gas chromatography MDHS 96 Volatile organic compounds in air - Laboratory method using pumped solid sorbent tubes, solvent desorption and gas chromatography Derived No Effect Level (DNEL) No information available Predicted No Effect Concentration (PNEC) No information available. Fresh water 2 mg/l Fresh water sediment 9.14 mg/kg dw Marine water 0.2 mg/l Marine water sediment 0.914 mg/kg dw Water Intermittent 1.65 mg/l Microorganisms in sewage treatment 4.2 mg/l Soil (Agriculture) 0.66 mg/kg dw 8.2. Exposure controls Engineering Measures Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are close to the workstation location. Use explosion-proof electrical/ventilating/lighting/equipment. Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to control hazardous materials at source Personal protective equipment Eye Protection Wear safety glasses with side shields (or goggles) (European standard - EN 166) Hand Protection Protective gloves Route of exposure Acute effects (local)^ Acute effects (systemic) Chronic effects (local) Chronic effects (systemic) Oral Dermal 44 mg/kg/d Inhalation 616 mg/m^3 308 mg/m^3 Glove material Breakthrough time Glove thickness EU standard Glove comments Nitrile rubber < 33 minutes 0.28 - 0.35 mm EN 374 Level 2 Permeation rate 36 μg/cm2/min As tested under EN374-3 Determination of Resistance to Permeation by Chemicals
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Diethyl ether, anhydrous, ACS Revision Date 18-Jan- 9.2. Other information Molecular Formula C4 H10 O Molecular Weight 74. Explosive Properties Vapors may form explosive mixtures with air Evaporation Rate 37.5 - (Butyl Acetate = 1.0)
SECTION 10: STABILITY AND REACTIVITY
10.1. Reactivity Yes 10.2. Chemical stability May form explosive peroxides, Air sensitive, Light sensitive, Hygroscopic. 10.3. Possibility of hazardous reactions Hazardous Polymerization Hazardous polymerization does not occur. Hazardous Reactions May form explosive peroxides. 10.4. Conditions to avoid Incompatible products. Heat, flames and sparks. Exposure to air. Exposure to light. Exposure to moisture. Keep away from open flames, hot surfaces and sources of ignition. 10.5. Incompatible materials Strong oxidizing agents. Strong acids. 10.6. Hazardous decomposition products Carbon monoxide (CO). Carbon dioxide (CO 2 ). peroxides.
SECTION 11: TOXICOLOGICAL INFORMATION
11.1. Information on hazard classes as defined in Regulation (EC) No 1272/ Product Information (a) acute toxicity; Oral Category 4 Dermal Based on available data, the classification criteria are not met Inhalation Based on available data, the classification criteria are not met Component LD50 Oral LD50 Dermal LC50 Inhalation Ethyl ether 1215 mg/kg (Rat) 20 mL/kg (Rabbit) 32000 ppm ( Rat ) 4 h (b) skin corrosion/irritation; Based on available data, the classification criteria are not met (c) serious eye damage/irritation; Based on available data, the classification criteria are not met (d) respiratory or skin sensitization; Respiratory Based on available data, the classification criteria are not met Skin Based on available data, the classification criteria are not met
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Diethyl ether, anhydrous, ACS Revision Date 18-Jan- (e) germ cell mutagenicity; Based on available data, the classification criteria are not met Mutagenic effects have occurred in experimental animals (f) carcinogenicity; Based on available data, the classification criteria are not met There are no known carcinogenic chemicals in this product (g) reproductive toxicity; Based on available data, the classification criteria are not met (h) STOT-single exposure; Category 3 Results / Target organs Central nervous system (CNS). (i) STOT-repeated exposure; Based on available data, the classification criteria are not met Target Organs None known. (j) aspiration hazard; Based on available data, the classification criteria are not met Other Adverse Effects See actual entry in RTECS for complete information Symptoms / effects,both acute and delayed Inhalation of high vapor concentrations may cause symptoms like headache, dizziness, tiredness, nausea and vomiting. 11.2. Information on other hazards Endocrine Disrupting Properties Assess endocrine disrupting properties for human health. This product does not contain any known or suspected endocrine disruptors.
SECTION 12: ECOLOGICAL INFORMATION
12.1. Toxicity Ecotoxicity effects Do not empty into drains. Component Freshwater Fish Water Flea Freshwater Algae Ethyl ether LC50: > 10000 mg/L, 96h static (Lepomis macrochirus) LC50: = 2560 mg/L, 96h flow-through (Pimephales promelas) EC50 = 165 mg/L/24h Component Microtox M-Factor Ethyl ether EC50 = 5600 mg/L 15 min 12.2. Persistence and degradability Persistence Persistence is unlikely, based on information available. 12.3. Bioaccumulative potential Bioaccumulation is unlikely Component log Pow Bioconcentration factor (BCF) Ethyl ether 0.82 No data available
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Diethyl ether, anhydrous, ACS Revision Date 18-Jan- 14.6. Special precautions for user No special precautions required 14.7. Maritime transport in bulk according to IMO instruments Not applicable, packaged goods
SECTION 15: REGULATORY INFORMATION
15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture International Inventories X = listed, Europe (EINECS/ELINCS/NLP), U.S.A. (TSCA), Canada (DSL/NDSL), Philippines (PICCS), China (IECSC), Japan (ENCS), Australia (AICS), Korea (ECL). Component EINECS ELINCS NLP TSCA DSL NDSL PICCS ENCS IECSC AICS KECL Ethyl ether 200-467-2 - X X - X X X X KE- 0 Regulation (EC) No 649/2012 of the European Parliament and of the Council of 4 July 2012 concerning the export and import of dangerous chemicals Not applicable National Regulations WGK Classification See table for values Component Germany - Water Classification (VwVwS) Germany - TA-Luft Class Ethyl ether WGK Component France - INRS (Tables of occupational diseases) Ethyl ether Tableaux des maladies professionnelles (TMP) - RG 84 UK - Take note of Control of Substances Hazardous to Health Regulations (COSHH) 2002 and 2005 Amendment 15.2. Chemical safety assessment A Chemical Safety Assessment/Report (CSA/CSR) has not been conducted
SECTION 16: OTHER INFORMATION
Full text of H-Statements referred to under sections 2 and 3 H224 - Extremely flammable liquid and vapor H302 - Harmful if swallowed H336 - May cause drowsiness or dizziness EUH019 - May form explosive peroxides EUH066 - Repeated exposure may cause skin dryness or cracking Legend CAS - Chemical Abstracts Service TSCA - United States Toxic Substances Control Act Section 8(b) Inventory EINECS/ELINCS - European Inventory of Existing Commercial Chemical Substances/EU List of Notified Chemical Substances DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List PICCS - Philippines Inventory of Chemicals and Chemical Substances ENCS - Japanese Existing and New Chemical Substances IECSC - Chinese Inventory of Existing Chemical Substances AICS - Australian Inventory of Chemical Substances KECL - Korean Existing and Evaluated Chemical Substances NZIoC - New Zealand Inventory of Chemicals
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Diethyl ether, anhydrous, ACS Revision Date 18-Jan- Key literature references and sources for data https://echa.europa.eu/information-on-chemicals Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS Training Advice Chemical hazard awareness training, incorporating labelling, Safety Data Sheets (SDS), Personal Protective Equipment (PPE) and hygiene. Use of personal protective equipment, covering appropriate selection, compatibility, breakthrough thresholds, care, maintenance, fit and standards. First aid for chemical exposure, including the use of eye wash and safety showers. Fire prevention and fighting, identifying hazards and risks, static electricity, explosive atmospheres posed by vapours and dusts. Chemical incident response training. Prepared By Health, Safety and Environmental Department Creation Date 15-Apr- Revision Date 18-Jan- Revision Summary SDS authoring systems update, replaces ChemGes SDS No. 60-29-7/3.
This safety data sheet complies with the requirements of Regulation (EC) No. 1907/
COMMISSION REGULATION (EU) 2020/878 amending Annex II to Regulation (EC) No
Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text End of Safety Data Sheet WEL - Workplace Exposure Limit TWA - Time Weighted Average ACGIH - American Conference of Governmental Industrial Hygienists IARC - International Agency for Research on Cancer DNEL - Derived No Effect Level Predicted No Effect Concentration (PNEC) RPE - Respiratory Protective Equipment LD50 - Lethal Dose 50% LC50 - Lethal Concentration 50% EC50 - Effective Concentration 50% NOEC - No Observed Effect Concentration POW - Partition coefficient Octanol:Water PBT - Persistent, Bioaccumulative, Toxic vPvB - very Persistent, very Bioaccumulative ADR - European Agreement Concerning the International Carriage of Dangerous Goods by Road ICAO/IATA - International Civil Aviation Organization/International Air Transport Association IMO/IMDG - International Maritime Organization/International Maritime Dangerous Goods Code MARPOL - International Convention for the Prevention of Pollution from Ships OECD - Organisation for Economic Co-operation and Development ATE - Acute Toxicity Estimate BCF - Bioconcentration factor VOC (volatile organic compound)
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