service rabbit
•Creative Biolabs offers the exclusive Native™ Antibody Discovery technology for custom development of
high affinity and specific native rabbit monoclonal antibodies. Through this proprietary technology, a lar
ge scale of candidate antibodies of native antibodies can be isolated from antigen-specific B lymphocyte
s of immunized rabbits.
•Rabbit is a kind of valuable laboratory animals for monoclonal antibody production. Rabbits can elicit str
ong immune response against foreign antigens and ideally working with peptide and protein antigens. C
ompared with mice and other rodents, which are the most commonly used host animals for monoclonal
antibody production, rabbits have their own advantages. Firstly, the immune response of rabbits has wi
der repertoires, improved recognition capability for small-size compounds and peptides, and the ability
to generate antibodies with higher binding affinity. Secondly, rabbit monoclonal antibodies displaying hi
gher sensitivity and specificity than mouse monoclonal antibodies, in some cases this means a reduced
necessity of antigen-retrieval pretreatments. In addition, they have more diverse epitope recognition re
sults in a highly diverse suite of B-lymphocytes, which is quite valuable for antigens with weak immunog
enicity or derived from rodents in particular. Ultimately, rabbit has a bigger spleen to provide an abunda
nce of splenocytes for antibody selection. After all, more available cells will give better chances to discov
er desired antibodies.
