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BMTCN Practice Test Questions and Answers 2025.
The administration of Epstein-Barr virus (EBV) cytotoxic T- lymphocytes has been found to be a feasible therapeutic option in which EBV mediated-disease process? a) Lymphoproliferative disease b) Neuroblastoma c) Nasopharyngeal rhabdomyosarcoma d) Acute lymphocytic leukemia - ANSWER A Donor leukocyte infusion is an appropriate treatment option for a patient who has relapsed post allogeneic transplant with: e) acute lymphocytic leukemia. f) severe aplastic anemia. g)chronic myelogenous leukemia. h) acute lymphoblastic lymphoma. - ANSWER C Which of the following is most important prognostic element for a patient being treated for pulmonary aspergillosis post- transplant? i) Granulocyte recovery j) Therapeutic serum fluconazole levels.
c) Serum IgG levels maintained greater than 400 d) Total number of CD34 positive cells in the donor's stem cells - ANSWER A The Foundation for the Accreditation of Cellular Therapy requires notification of positive microbial culture results on cellular therapy products to the: e) recipient f) donor g)Food and Drug Administration. h) American Association of Blood Banks - ANSWER A A patient is undergoing peripheral blood stem cell mobilization for an autologous transplant and starts to experience fever, fatigue and bone pain. This is most likely due to: i) a bacterial infection. j) growth factors. k)cytokine storm. l) bone marrow hypoplasia. - ANSWER B What is the best initial step in determining the evidence available to support a current nursing intervention? m)Conduct a research study comparing two different processes to see which is better n) Ask fellow nurses on the unit what their current practice is o)Review current literature regarding the intervention, identify gaps or
d) Nystatin suspension - ANSWER A Which of the following factors is associated with primary graft failure? a) Peripheral blood stem cell graft source b) Viral infection in the recipient c) HLA match with the donor d) CD34 selected cellular product - ANSWER B The caregiver of a patient at a clinic reports witnessing unusual and aggressive behavior, sleep problems, and sadness. The nurse believes the patient may be exhibiting signs of: e) Posterior reversible encephalopathy syndrome (PRES) f) Bipolar disorder g)PTSD h) Tacrolimus toxicity - ANSWER C Cataract development post transplant is linked to which of the following treatment regimens? i) TBI j) Fludarabine k)Carboplatin l) Etoposide - ANSWER A When providing information to a patient diagnosed with cutaneous chronic graft versus host disease, the nurse emphasizes:
a) There is not an increased risk of infection during treatment b) The importance of tapering steroid medications c) That steroid creams are ineffective d) The importance of using sunscreen with adequate SPF barrier - ANSWER D Which of the following is the first step in the pathophysiological process for acute GVHD? e) Damage of host tissue f) Engraftment syndrome g)Cytokine release syndrome h) Inflammatory effectors - ANSWER A Stem cell products with an ABO incompatibility between donor and recipient are managed by which of the following? i) Product irradiation prior to infusion j) Removal of white blood cells through filtering k)Cryopreservation to prevent an adverse reaction l) Depletion of red blood cells after collection - ANSWER D Which statement by a nurse would indicate further teaching about transplant recipients is required? "Important criteria used to evaluate a patient for HSCT include: m)support resources available to the patient" n) age of the caregivers"
sensation in the eyes and sensitivity to light. Which of the following interventions will most likely be ordered? a) Digital eye exam b) Phototherapy c) Schirmer's test d) Systemic corticosteroids - ANSWER C Which of the following decreases the risk of developing acute GVHD after an allogeneic transplant for a male patient? e) Unrelated female donor f) Human leukocyte antigen disparity g)Infusion of increased number of stem cells h) Depletion of T lymphocytes from allograft - ANSWER D Which of the following is a characteristic of stromal cells? Stromal cells: i) Are found in the brain j) Differentiate into epithelium k)Are the primary location of hematopoiesis l) Are responsible for producing immunoglobulins - ANSWER C Which of the following is a disadvantage in the use of umbilical cord blood? m)Increased risk of graft failure n) Cost
c) Difficult collection process d) Higher risk of GVHD - ANSWER A The cluster of differentiation system is used to: e) Identify different types of cytokines f) Crossmatch for blood product transfusion g)Measure immune function h) Classify cell surface proteins on leukocytes - ANSWER D Two hours after an HSCT infusion, a patient calls for the nurse to report red urine. What is the most likely cause? i) Hemorrhagic cystitis j) A low platelet count k)Medications given prior to transplant l) Breakdown of red blood cells in the product - ANSWER D A patient continues to have symptoms of acute GVHD after a fourteen day course of glucocorticoids. What medication does the nurse anticipate an order for? m)Mineralocorticoids n) Intravenous immunoglobulin o)Cyclosporine p) Antithymocyte globulin (ATG) - ANSWER D Grapefruit should be avoided when taking which of the following
Secondary graft failure can be a complication of which of the following? a) Increased cell dose of graft source b) Pulmonary fibrosis c) Venocclusive disease of the liver d) Viral infection - ANSWER D A nurse on an inpatient transplant unit reports experiencing altered sleep patterns, inability to concentrate, feeling helpless and indifferent following the death of a patient. What is the nurse most likely experiencing? a) Compassion fatigue b) Ethical conflict c) Moral uncertainty d) Anxiety and depression - ANSWER A Which of the following is a non-HLA barrier for transplant research? a) Allele matching of donors to recipients b) FACT accredidation
c) Large numbers of transplant patients available at each facility d) Heterogeneity of risk factors - ANSWER D A 45-year old female with acute myeloid leukemia arrives for her pre-transplant evaluation. The patient's twin sister offers to donate, but the physician opts to use a donor from the National Marrow Donor Program because: a) The patient's sister is also identified as her caregiver b) Syngeneic transplants increase the risk of tumor relapse c) The cost of immunosuppression medication is high d)The physician prefers to use the National Marrow Donor Program - ANSWER B Annual gynecologic examinations and vaccinations against human papillomavirus are important aspects of routine health maintenance for patients following allogeneic transplant because patients: a) Post allogeneic transplant are at increased risk of aGVHD b) Are at increased risk for gynecomastia following transplant c) Are at increased risk of contracting STIs
a) Aspergillus b) Epstein Barr virus c) Candida d) Cytomegalovirus - ANSWER B Essential steps to protect the nurse prior to administration of chemotherapeutic agents include: a) Washing hands b) Donning gown and gloves c) Verifying the dosage d) Priming intravenous tubing at the bedside - ANSWER B The patient's preparative regiment includes busulfan, fludarabine, and antithymocyte globulin. The nurse plans to administer which medication prior to the antithymocyte globulin infusion? a) Ondansetron b) Mannitol c) Aspirin d) Diphenhydramine - ANSWER D
While explaining the goals of stem cell transplant to a patient with acute myeloid leukemia, the nurse emphasizes that transplantation will: a) Produce a graft versus leukemia effect b) Improve immune system function c) Provide a chimeric graft post- transplant d) Reduce tumor burden - ANSWER A Which of the following is a potential barrier in advanced care planning for patients who have received an HSCT? a) Difficulty understanding documents b) Accessibility to a lawyer c) Length of time required to complete documents d) Provider discomfort discussing end-of-life issues - ANSWER D Which of the following is a contributing factor to the development of sinusoidal obstructive syndrome in the early post-transplant period? a) Drug metabolites
Which medication is used in conjunction with extracorporeal photopheresis? a) Mercaptopurine b) Fluorouracil c) Thioguanine d) Methoxsalen - ANSWER D Which of the following is a strong predictor of a relapse following allogeneic HSCT? a) Patient age b) Stem cell source c) Disease stage d) Presence of graft versus host disease - ANSWER C A patient with chronic GVHD who is prescribed steroids needs to be re-immunized. The nurse knows that the patient can receive immunizations when the GHVD is resolved and the steroid dose is less than: a) 20 mg/day b) 5 mg/day
c) 15 mg/day d) 10 mg/day - ANSWER B What is the most appropriate intervention for a patient taking tacrolimus twice daily with a level of 25ng/ml? a) Withhold the dose of tacrolimus b) Administer the tacrolimus c) Discontinue the tacrolimus d) Increase the tacrolimus dose - ANSWER A Which of the following can be an additional site if there is an inadequate amount of bone marrow aspirated from the iliac crest? a) Coccyx b) Femur c) Humerus d) Sternum - ANSWER D Following an allogeneic transplant, a patient arrives at clinic reporting weakness and fatigue that has worsened over the past week. Which nursing
a) Potassium b) Magnesium c) Calcium gluconate d) PRBCs - ANSWER C Which of the following factors increases the risk of squamous cell carcinoma following transplant? a) History of non-Hodgkin lymphoma b) History of acute myelogenous leukemia c) Previous diagnosis of aGVHD d) Underlying diagnosis of Fanconi anemia - ANSWER D A nurse reflecting on professional practice may consider: a) The Three Rights of Delegation b) Side effects of a chemotherapy agent c) Sharing details of patient care with a mutual friend d) How to maintain professional boundaries - ANSWER D
A patient's preparative regiment includes thiotepa. Essential patient education includes: a) The importance of showering 2-3x per day for 24 hours after the infusion b) Kidney dysfunction is common with thiotepa administration c) The use of moisturizers on the skin to prevent skin irritation d)Hemorrhagic cystitis is a complication of thiotepa administration - ANSWER A Which of the following is an example of a myeloid cell? a) Thymus-derived cells (T cells) b) Bone marrow-derived cells (B cells) c) Monocytes d) Natural killer cells - ANSWER C Several factors affect immune reconstitution following hematopoietic stem cell transplantation (HSCT). These include all of the following EXCEPT: a) Recipient's response to conditioning regimen b) Viral infection
