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Introduction: A pedigree is a visual chart that depicts a family history or the transmission of a specific trait.
Typology: Lecture notes
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*Biology Name ___________________________ Date________________ Period_______
Introduction: A pedigree is a visual chart that depicts a family history or the transmission of a specific trait. They can be interesting to view and can be important tools in determining patterns of inheritance of specific traits. Pedigrees are used primarily by genetic counselors when helping couples decide to have children when there is evidence of a genetically inherited disorder in one or both families. They are also used when trying to determine the predisposition of someone to carry a hereditary disease for example, familial breast cancer. The Components of a Pedigree: Squares are used to indicate males in a family. Circles are used to indicate females. If the individual is “affected" by the trait (dominant or recessive) we darken the shape. A line between a male and a female indicates a marriage or union. A line drawn down from the marriage line indicates offspring. Sometimes, you will see some shapes filled in only half way - this notation indicates a hybrid (heterozygous) or carrier of the trait. Read pages 396-397 (Sect. 14.1) in your textbook for more information.
Analyzing Simple Pedigrees: A pedigree is just like a family tree except that it focuses on a specific genetic trait. A pedigree usually only shows the phenotype of each family member. With a little thought, and the hints below, you may be able to determine the genotype of each family member as well! Hints for analyzing pedigrees:
For Questions 1-9, use the pedigree chart shown below. Some of the labels may be used more than once. ________ 1. A male
2. A female ________ 3. A marriage 4. A person who expresses the trait 5. A person who does not express the trait 6. A connection between parents and offspring ________ 7. How many generations are shown on this chart? Assuming the chart above is tracing the dominant trait of "White Forelock (F)" through the family. F is a tuft of white hair on the forehead. ________ 8. What is the most likely genotype of individual “A”? (FF, Ff or ff?) ________ 9. What is the most likely genotype of individual “C”? (FF, Ff or ff?)
*Example 2: Tracing the path of an autosomal dominant trait Trait: Neurofibromatosis Forms of the trait: The dominant form is neurofibromatosis, caused by the production of an abnormal form of the protein neurofibromin. Affected individuals show spots of abnormal skin pigmentation and non-cancerous tumors that can interfere with the nervous system and cause blindness. Some tumors can convert to a cancerous form. The recessive form is a normal protein - in other words, no neurofibromatosis. A typical pedigree for a family that carries neurofibromatosis is shown below. Note that carriers are not indicated with half-colored shapes in this chart. Use the letter "N" to indicate the dominant neurofibromatosis allele, and the letter "n" for the normal allele. Analysis Questions:
nn nn nn Nn N-