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Table e-1. Japan Coma Scale for grading impaired consciousness* Grade Consciousness Level 1-digit code The patient is awake without any stimuli, and is: 1 Almost fully conscious 2 Unable to recognize time, place, and person 3 Unable to recall name or date of birth 2-digit code The patient can be aroused (then reverts to previous state after cessation of stimulation): 10 By easily by being spoken to (or is responsive with purposeful movements, phrases, or words)† 20 With a loud voice or shaking of shoulders (or is almost always responsive to very simple words like yes or no or to movements) 30 Only by repeated mechanical stimuli 3-digit code The patient cannot be aroused with any forceful mechanical stimuli, and: 100 Responds with movements to avoid the stimulus 200 Responds with slight movements, including decerebrate and decorticate posture 300 Does not respond at all except for changes in respiratory rhythm
*"R" and "I" are added to the grade to indicate restlessness and incontinence of urine and feces, respectively: for example; 100-R and 30-RI. †Criteria in parentheses are used in patients who cannot open their eyes for any reason
Table e-2. The interaction analysis between usage of DOAC and reversal agents on ICH removal by logistic regressions.
OR 95% CI P value Usage of DOAC Usage of reversal agents
Interaction between DOAC and reversal agents 5.02 0.92-27.28 0.
Abbreviations: OR, odds ratio; CI, Confidence interval; DOAC, direct oral anticoagulants
Table e-4. Characteristics of DOAC and warfarin-associated ICH patients matched by propensity score.
Variable DOAC Warfarin n=221 n= Mean or % P value Male 76.5 74.7 0. Age 73.3 74.5 0. Charlson score 4.8 4.9 0. Hypertension 60.6 56.1 0. Diabetes mellitus 26.7 23.1 0. Hyperlipidemia 14.0 12.2 0. JCS score 2 or 3-digit code 26.7 30.8 0. Concurrent antiplatelet therapy 24.4 25.8 0. ICH removal 5.9 5.4 0. External CSF drainage 2.7 2.3 0. Vitamin_K 2.7 2.7 1 PCC 5.0 2.7 0. FFP 5.4 3.6 0.
Abbreviations: DOAC, direct oral anticoagulants; ICH, intracerebral hemorrhage; CSF, cerebrospinal fluid; PCC, prothrombin complex concentrate; FFP, Fresh frozen plasma
Table e-5. ORs of mortality within 1 day, 7 days and during hospitalization, and mRS 4-6 at discharge in warfarin-associated ICH patients compared with dabigatran-associated ICH patients after matching by propensity score.
OR 95% CI P value Mortality within 1 day 2.44 0.32-18.42 0. Mortality within 7 days 1.45 0.26-8.14 0. In-hospital mortality 2.11 0.47-9.45 0. Discharge mRS 4-6 1.02 0.35-3.00 0.
Abbreviations: OR, odds ratio; CI, Confidence interval; mRS, modified Rankin Scale; DOAC, direct oral anticoagulants
Table e-7. ORs of mortality within 1 day, 7 days and during hospitalization, and mRS 4-6 at discharge in warfarin-associated ICH patients compared with rivaroxaban-associated ICH patients after matching by propensity score.
OR 95% CI P value Mortality within 1 day 11.22 1.40-90.27 0. Mortality within 7 days 2.23 0.94-5.31 0. In-hospital mortality 1.48 0.73-3.00 0. Discharge mRS 4-6 0.45 0.17-1.15 0.
Abbreviations: OR, odds ratio; CI, Confidence interval; mRS, modified Rankin Scale
