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Various aspects of the vascular system, including the role of different cell types, arterial functions, compliance, blood flow regulation, and the lymphatic system. Topics covered include the types of cells lining blood vessels, arterial pressure maintenance, compliance definition and factors affecting it, normal blood pressure values, aging effects on arterial pressure, korotkoff's sounds, arteriolar functions, and local vs. Extrinsic blood flow control. Additionally, it discusses the differences between hyperemia, active hyperemia, and reactive hyperemia, chemical factors influencing arteriolar dilation, and the sources and effects of vasodilators and vasoconstrictors.
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Chapter 12 Section C The Vascular System Revised 17 October 2007 What type of cell lines blood vessels of all types and lines the lumen of the heart chambers? How do arteries act as pressure reservoirs? What is the mathematical definition of compliance? Are arteries considered highly compliant? How do smooth muscles affect compliance of arteries? What are the normal values for systolic and diastolic pressure and pulse pressure? Why doesn't arterial pressure fall to zero between heart beats? What would mean arterial pressure be if systolic pressure is 130 and diastolic pressure is 80 mmHg? How does blood pressure typically change with advancing age? Why so? What are Korotkoff’s sounds? Are these sound heart murmurs? What are the two major functions of arterioles? How do arteriolar smooth muscles mediate vasodilation or vasoconstriction? What percentage of blood flow goes to the heart, kidney, and brain at rest? (see p. 449) What intrinsic tone? How does local control of blood flow differ from extrinsic control? What is the difference between hyperemia, active hyperemia, and reactive hyperemia? What are some of the local chemical factors that lead to arteriolar dilation? What effect do these factors have on arteriolar smooth muscle? In which tissues is local control of blood flow predominant? How is local control good for matching blood flow to metabolic rate of the tissue? What is it called when blood flow is kept relatively constant in spite of changes in blood pressure? How are local metabolic factors involved in this phenomenon? Since the same factors are at work in flow autoregulation and active hyperemia, how do they initially differ? What is the myogenic response and what ion in involved? What is reactive hyperemia? What effect does norepinephrine have on vascular smooth muscle? Which receptor type is involved?
Why don't "beta blockers" have a large effect vascular smooth muscle? How can vasodilation be achieved via the sympathetic nerves? Is it typical for most arteriolar smooth muscle to be "dually innervated?" What is the source of nitric oxide, a vasodilator? (Caution….there are actually two important sources!) In which arterioles is this agent important? How can epinephrine cause arteriolar smooth muscle to either contract or relax? What are the effects of angiotensin II, vasopressin, and atrial natriuretic factor arteriole diameter? Name two vasodilators and one vasoconstrictor released by endothelial cells. According to table 12-5, which organs have their blood flow determined mainly by flow autoregulation? In which is blood flow controlled mainly by local metabolic factors? At any moment, what percentage of blood volume is in the capillaries? What is the diameter of a capillary? How does this compare to the diameter of an erythrocyte? Define angiogenesis. What are intracellular clefts of capillaries? How does a fused vesicle channel form in a capillary? What are metarterioles and what is their function? What is the function of precapillary sphincters? In which type of blood vessel is blood velocity the slowest? the fastest? How is it possible for blood velocity to be faster in veins than in capillaries, especially since the pressure is lower in veins? Why isn't the resistance of capillaries, which are obviously smaller diameter than arterioles, greater than the resistance of arterioles? What are the 3 means by which substance move across capillary walls? Which of these is most important for moving nutrients, gases, and waste products? What is unusual about the capillaries of the brain? Which organs have capillaries that are the "tightest?" the "leakiest?" How does metabolism affect the rate of diffusion? What is the difference between diffusion and bulk flow?