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Thyroid Hormone Physiology, Study notes of Physiology

Banaras Hindu UniversityPhysiology

Thyroid hormone physiology and its synthesis.

Typology: Study notes

2022/2023

Available from 12/29/2023

ankit-meena-1
ankit-meena-1 🇮🇳

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bg1
*
PHYSIOLOGY
OF
THYROID
Th
D
HcOll
Ic
A
TG
&
%
!
reduced
expression
in
Ca.
*
Pendrin
thyroid
Pendid
Syndrome
-
guitary
nearing
boys
·
Organification
(I to
2)
↳
with
help
of
2
enzymes
<TP
x-2
(Mar
Oxidase
↳
synthesis
of
HCO2
①
Mansport
Basolateral
↳
apical
②
Organification
⑤
Jodination
⑪
Coupling
⑤
endocytosis
⑥
proteolysis
(va
deiodinase)
&
release
⑦
peripheral
conversion
pf3
pf4
pf5

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* PHYSIOLOGY^ OF^ THYROID

Th D HcOll Ic A TG & % !

reduced expression in^ Ca.

* Pendrin

thyroid Pendid (^) Syndrome

  • guitary

nearing boys

· Organification (I to^ 2) with (^) help (^) of 2

enzymes

<TPx-2 (^) (Mar Oxidase synthesis of^ HCO ① (^) Mansport Basolateral apical ② (^) Organification ⑤ Jodination ⑪ Coupling ⑤ (^) endocytosis

⑥ proteolysis (va deiodinase) & release

⑦ peripheral conversion

* Recommended^ Dietary Intake^ :

Adults >^150 Mg

Pregnancy (^) 220mg children (^) 90-120 (^) Mg

· Peripheral conversion (Ty + is)

80 % - peripheral conversion

20 %,^ produced in

gland) hypothyroidism

by deiodinase^ enzyme

(seleno-iodinase enzyme)

Type I^ :^ Reverse^ is^ degradation Type It^ :^ more^ affinity^ for^ in

Type I

: (^) in + RTs (Placental ·

Thyroid funct

not done (^) : IICO^ pt ②

fasting

③ (^) systemic ds.

⑪ high iodide levels

· sick

euthyroid syndrome^ :

ICOW Ts^ syndrome (

-^ -

PHASE -^ I^ PHASE^ -^ I^ PHASE

Normal (^) in increasedIn decreased (^) in low (^) is low (^) is low (^) is increased (^) rTz increased (^) rTz increased (^) rTz Normal (^) TSH low TSH Low TSH