Perclose ProGlide Vascular Closure Device – Stepwise
Practical Guide
This document summarizes the practical steps, mechanism, troubleshooting, and procedural pearls for use of the
Perclose ProGlide vascular closure device, commonly used for large bore femoral arterial and venous access closure.
1. Purpose of Perclose Device
Perclose ProGlide is a suture-mediated vascular closure device used to achieve hemostasis after femoral vascular
access. It is especially useful in large bore procedures such as TAVI, EVAR, Impella, ECMO, and leadless pacemaker
implantation.
2. Main Device Components
Important components include:
• Footplate
• Needle deployment system
• Suture mechanism
• Plunger and lever controls
• Guidewire rail system
3. Preclose Technique
In large bore procedures, Perclose devices are commonly deployed before insertion of the final large sheath. Sutures
are left untied during the procedure and tightened after sheath removal.
4. Step-by-Step Procedure
Step 1: Obtain ideal common femoral artery access under ultrasound and fluoroscopic guidance.
Step 2: Maintain guidewire access securely within the vessel.
Step 3: Make a small skin nick to facilitate device entry.
Step 4: Advance the Perclose device over the guidewire until blood exits the marker port, confirming intraluminal
positioning.
Step 5: Remove guidewire and deploy the footplate.
Step 6: Pull back gently until resistance is felt, indicating apposition of the footplate against the vessel wall.
Step 7: Press the plunger to deploy needles and pass the suture through the vessel wall.
