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inlantyle paralysis-poliomyelitis, Vodiči, Projekti, Istraživanja od Biologija

This text provides an overview of poliomyelitis (polio), an infectious viral disease caused by the poliovirus. It discusses the history of polio, the types of polioviruses, and how the virus affects humans. The text explains that most infections are asymptomatic, but in rare cases, the virus can cause paralysis or death. It details the transmission methods, symptoms, and the lack of a specific cure, emphasizing that prevention through vaccination (using IPV and OPV vaccines) is the most effective way to combat the disease.

Tipologija: Vodiči, Projekti, Istraživanja

2023/2024

Učitan datuma 19.08.2024.

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Infantile paralysis-Poliomyelitis
Poliomyelitis or Polio is an infectious viral
disease caused by poliovirus, which is an RNA
virus of the family Picornaviridae, genus
Enterovirus. Infantile paralysis was first recognized
by the German orthopedist Jacob Heine in 1840,
and a little later Karl Landsteiner discovered the
cause of the disease, namely the poliovirus itself.
This genus of viruses in natural conditions is pathogenic only for humans, ie. infects
and causes disease only in humans, i.e. humans are the only natural hosts.
According to the antigenic structure, there are 3 types of polioviruses, which are
designated as Type 1, Type 2 and Type 3. Type 1 causes paralysis and epidemics,
Type 2 usually causes inapparent (non-symptomatic) infections, and Type 3 causes
mild cases of poliomyelitis, and sometimes epidemics.
Polioviruses enter the human body through the digestive tract and usually do not cause
any visible changes, that is, most people (80-90% of those infected) do not get sick and
are not aware that they are infected with polio.
The reservoir of polioviruses is found in the person who suffers from any form of
poliomyelitis and is a virus carrier. The virus leaves the infected organism with the
nasopharyngeal secretion in the first days of the disease, and later with the feces.
Polioviruses are transmitted rarely through direct contact and through droplets from
nasopharyngeal secretions. Most often they are transmitted through food items and
drinking water, as well as through various objects of general use that are contaminated
with polioviruses. In a certain number of cases, they cause a febrile illness with a
headache - that it is called abortive poliomyelitis. In a small number of cases, 5-7 days
after those symptoms, the temperature will appear again and with it severe headaches
and signs of meningitis occur. This form of poliomyelitis is called non-paralytic
poliomyelitis. In non-paralytic forms of infection, the prognosis is good.
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Infantile paralysis-Poliomyelitis

Poliomyelitis or Polio is an infectious viral disease caused by poliovirus, which is an RNA virus of the family Picornaviridae, genus Enterovirus. Infantile paralysis was first recognized by the German orthopedist Jacob Heine in 1840, and a little later Karl Landsteiner discovered the cause of the disease, namely the poliovirus itself. This genus of viruses in natural conditions is pathogenic only for humans, ie. infects and causes disease only in humans, i.e. humans are the only natural hosts. According to the antigenic structure, there are 3 types of polioviruses, which are designated as Type 1, Type 2 and Type 3. Type 1 causes paralysis and epidemics, Type 2 usually causes inapparent (non-symptomatic) infections, and Type 3 causes mild cases of poliomyelitis, and sometimes epidemics. Polioviruses enter the human body through the digestive tract and usually do not cause any visible changes, that is, most people (80-90% of those infected) do not get sick and are not aware that they are infected with polio. The reservoir of polioviruses is found in the person who suffers from any form of poliomyelitis and is a virus carrier. The virus leaves the infected organism with the nasopharyngeal secretion in the first days of the disease, and later with the feces. Polioviruses are transmitted rarely through direct contact and through droplets from nasopharyngeal secretions. Most often they are transmitted through food items and drinking water, as well as through various objects of general use that are contaminated with polioviruses. In a certain number of cases, they cause a febrile illness with a headache - that it is called abortive poliomyelitis. In a small number of cases, 5-7 days after those symptoms, the temperature will appear again and with it severe headaches and signs of meningitis occur. This form of poliomyelitis is called non-paralytic poliomyelitis. In non-paralytic forms of infection, the prognosis is good.

Very rarely, in about 0.5% of cases, the disease progresses further and the virus causes degenerative changes in the cells of the anterior horns of the spinal cord and in the motor brain nerves. This leads to paralysis, mostly in the lower limbs. If the motor nerves of the Medulla oblongata are affected, death occurs quickly due to paralysis of the interosseous muscles. Poliomyelitis is confirmed virologically—by isolating the virus from the throat or stool, or serologically—by demonstrating a rise in specific antibodies. People who recover from poliomyelitis remain solidly protected, but only against the type that caused the disease in them. Since there is no cure, nor specific therapy for polio, treatment focuses on speeding up recovery and preventing complications. The best prevention is achieved through immunoprophylaxis - there are two types of vaccines : Inactive polio vaccine (IPV) which contains an inactive form of polio virus type 1, 2 and 3, as well as Oral polio vaccines (OPV) which contains attenuated (weakened) polio virus. The polio vaccine is included in the routine childhood vaccination and it is mandatory in our country by law. All children from 6 months of age are subject to vaccination.