M.PHARM Degree Examination: Drug Design and Molecular Pharmacology, Schemes and Mind Maps of Design

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September 2009 [KV 327] Sub. Code: 2863 M.PHARM. DEGREE EXAMINATION (Regulations 2006) Candidates admitted from 2006-2007 onwards FIRST YEAR Branch IV – PHARMACOLOGY Paper IV – DRUG DESIGN AND MOLECULAR PHARMACOLOGY Q.P. Code : 262863 Time : Three hours Maximum : 100 marks Answer All questions I. Essay Questions : (3 x 20 = 60)

1. Classify receptors. Explain the various theories and forces involved in drug receptor interaction.
2. Briefly enumerate the principles, process and applications of recombinant DNA technology.
3. Brief out the clinical applications of gene therapy and disease targets for gene therapy.

II. Write Short Notes : (8 x 5 = 40)

1. Partition co-efficient.
2. Write the physicochemical parameters in QSAR.
3. Write the drug designing of pro-drugs.
4. Give the general applications of procedure pharmacology.
5. Write the importance of chelates in medicine.
6. Write the principles of computer aided drug design.
7. Isosterism.
8. Write a note on viral vectors in gene therapy.

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March 2010 [KW 327] Sub. Code: 2863 M.PHARM. DEGREE EXAMINATION (Regulations 2006) Candidates admitted from 2006-2007 onwards FIRST YEAR Branch IV – PHARMACOLOGY Paper IV – DRUG DESIGN AND MOLECULAR PHARMACOLOGY Q.P. Code : 262863 Time : Three hours Maximum : 100 marks Answer All questions I. Essay Questions : (3 x 20 = 60)

1. Define gene therapy. Discuss in detail the different types of gene therapy.
2. Discuss briefly the receptor polymorphism and dimerization and its importance in drug design.
3. Briefly discuss the various structural factors in drug design.

II. Write Short Notes : (8 x 5 = 40)

1. Applications of molecular pharmacology.
2. QSAR parameters related to chemical structure.
3. Classify receptors.
4. Write a brief note on gene mapping.
5. Isolation of RNA from yeast.
6. Application of pro-drug.
7. Cell signaling.
8. Oxidation reduction potential.

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MAY 2011

[KY 327] Sub. Code: 2863

M.PHARM. DEGREE EXAMINATION (Regulations 2006) (Candidates admitted from 2006-2007 onwards) FIRST YEAR BRANCH IV – PHARMACOLOGY PAPER IV – DRUG DESIGN AND MOLECULAR PHARMACOLOGY Q.P. Code : 262863 Time : Three hours Maximum : 100 marks Answer All questions I. Essay Questions : (3 x 20 = 60)

1. Write in detail about Overton and Mayer theory. Also explain the exceptions of the theory.
2. Write in detail about geometric isomerism and conformational isomerism on pharmacological activity?
3. Enumerate various cell signalling methods? Describe the various secondary messengers involved in signal transduction pathway?

II. Write Short Notes : (8 x 5 = 40)

1. Clinical applications of gene therapy.
2. Tryptophan operon model.
3. Organization of DNA in cells and the role of histones?
4. Application of prodrug in parenteral dosage forms.
5. What are receptor binding assays? Explain in detail.
6. Computational combinatorial ligand design
7. Explain the process of translation of proteins.
8. Southern blotting.