1) Alpha - adrenergic blockers
Block alpha-adrenergic receptors, resulting in
vasodilation and decreased blood pressure
They decrease VLDL and LDL that are responsible for
atherosclerosis (build-up of fatty plaques in the
arteries). In addition, they increase HDL levels
("friendly lipoprotein")
Alpha blockers do not affect glucose metabolism and
they do not affect respiratory function. They are safe
for patients with diabetes and COPD.
These drugs cause sodium and water retention with
edema. Diuretics are frequently given with alpha-
adrenergic blockers to decrease fluid accumulation in
the extremities.
Examples of Alpha- adrenergic Blockers
Selective Alpha - Adrenergic Blockers
Cardura (Doxazosin Mesylate)
Minipress (Prazosin HCI)
Hytrin (Terazosin HCI) Non-selective Alpha -
Adrenergic blockers
Dibenzyline (Phenoxybenzamine HCI)
Regitine (Phentolamine)
Priscoline HCI (Tolazoline HCI)
(Phentolamine, Phenoxybenzamine and Tolazoline are
more potent alpha blockers and are used primarily
for hypertensive crisis and severe hypertension due
to pheochromocytoma).
