Advanced Pathophysiology: Cellular Structure and Function, Study Guides, Projects, Research of Pathophysiology

A comprehensive review of the key concepts and principles related to cellular structure and function in the context of advanced pathophysiology. It covers topics such as cellular differentiation, eukaryotic cell components, cellular communication, energy production, membrane potentials, and various types of cellular injury and adaptation. The document delves into the intricate details of cellular processes, including signal transduction, ion regulation, and acid-base balance, which are crucial for understanding the underlying mechanisms of disease and the body's response to various stimuli. By studying this document, students can gain a deeper understanding of the fundamental cellular processes that underlie human health and disease, enabling them to better comprehend the pathophysiology of various clinical conditions and develop more effective treatment strategies.

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2023/2024

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NSG 5003 Advanced Pathophysiology Study Guide Review
1. Differentiation (maturation) process in which
cells become specialized in
structure and function
2. The eight specialized cellular func-
tions are movement, conductivity,
metabol- ic absorption,
secretion, excretion,
respiration, reproduction,
communi- cation
3. Eukaryotic cells Contain a nucleus and other
or- ganelles that are bound
by mem- branes.
4. The eukaryotic cell consists of
three general components plasma membrane, cytoplasm,
and intracellular organelles
5. Nucleus A part of the cell containing
DNA and RNA and responsible
for growth and reproduction
6. Vaults cytoplasmic organelles that
are car- rying messengers of
ribonucleic acid (mRNA) from
the nucleus to the ribosomal
sites of protein synthesis
7. plasma membrane (cell membrane) It's function is to protect the
cell and
control what goes in and out. It
is not a solid structure. It is
made of millions of smaller
molecules so it is flexible and
porous (allows things to pass
through it).
8. cellular receptors protein molecules on the
plasma membrane, in the
cytoplasm, or in the nucleus
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1 / NSG 5003 Advanced Pathophysiology Study Guide Review

  1. Differentiation (maturation) process in which cells become specialized in structure and function
  2. The eight specialized cellular func- tions are movement, conductivity, metabol- ic absorption, secretion, excretion, respiration, reproduction, communi- cation
  3. Eukaryotic cells Contain a nucleus and other or- ganelles that are bound by mem- branes.
  4. The eukaryotic cell consists of three general components plasma membrane, cytoplasm, and intracellular organelles
  5. Nucleus A part of the cell containing DNA and RNA and responsible for growth and reproduction
  6. Vaults cytoplasmic organelles that are car- rying messengers of ribonucleic acid (mRNA) from the nucleus to the ribosomal sites of protein synthesis
  7. plasma membrane (cell membrane) It's function is to protect the cell and control what goes in and out. It is not a solid structure. It is made of millions of smaller molecules so it is flexible and porous (allows things to pass through it).
  8. cellular receptors protein molecules on the plasma membrane, in the cytoplasm, or in the nucleus

2 / NSG 5003 Advanced Pathophysiology Study Guide Review that can recognize and bind with specific smaller molecules called ligands

  1. Ligands A molecule that binds specifically to a receptor site of another molecule.

4 / NSG 5003 Advanced Pathophysiology Study Guide Review

  1. Resting Membrane Potential (RMP) charge difference across the plas- ma membrane
  2. action potential the change in electrical potential as- sociated with the passage of an

3 / impulse along the membrane of a muscle cell or nerve cell.

  1. atrophy to waste away
  2. hypertrophy increase in cell size
  3. Hyperplasia increase in the number of the cells in a tissue or organ
  4. Dysplasia (aka atypical hyperplasia) abnormal development or growth of cells, tis- sues, or organs
  5. Metaplasia Mature cell type is replaced by a different mature cell type
  6. Cell injury mechanisms -free radical formation -hypoxia & ATP depletion -intra-cellular calcium accumulation
  7. hypoxia/anoxia decreased oxygen/lack of oxygen
  8. free radicals can cause 1) lipid peroxidation or the destruc- tion of unsaturated fatty acids
    1. alterations of proteins
    2. alterations in DNA
  9. Activation of inflammation and immu- nity occurs after cellular injury or infec- tion involving powerful biochemicals & proteins capable of damaging nor- mal (uninjured & uninfected) cells
  10. Genetic disorders injure cells by altering the nucleus and the

5 / of the transport mechanisms, chro- mosomes, nucleus, and DNA.

  1. Injurious physical agents include temperature extremes & climate changes, changes in atmospheric pressure, ionizing radiation, illumi- nation, mechanical stress (repetitive body movements) & noise
  2. Systemic manifestations of cellular injury include
  3. T/F: A eukaryotic cell contains struc- tures called organelles fever, leukocytosis, increased heart rate, pain, and serum elevations of enzymes in the plasma True
  4. Necrosis tissue death
  5. - lysis destruction
  6. Apoptosis process of programmed cell death
  7. function of histones help maintain the shape of the chro- mosome and aid in the tight packing of DNA, and do not affect cellular division, movement, or activities.
  8. An organelle that is responsible for the metabolism of cellular energy is referred to as a/an mitochondrion
  9. Mitochondria Powerhouse of the cell, organelle that is the site of ATP (energy) pro- duction

6 /

  1. Golgi complex Organelle that packages and distrib- utes proteins
  2. Nucleolus Makes ribosomes

8 / selec- tively permeable membrane

  1. Filtration A process that separates materials based on the size of their particles.

9 /

  1. hydrostatic pressure The pressure of water against the walls of its container.
  2. Catabolism Metabolic pathways that break down molecules, releasing energy.
  3. Anabolism Metabolic pathways that construct molecules, requiring energy.
  4. Substrate reactant of an enzyme- catalyzed re- action
  5. Amphipathic molecules are molecules that contain both hy- drophobic and hydrophilic regions
  6. Which are the roles of relay chains in signal transduction? Transfer the signal, Amplify the sig- nal, and Distribute the signal
  7. functions of proteins structural support, catalyst, trans- port, defense, movement, regula- tion
  8. Intracellular fluid (ICF) fluid inside cells
  9. Extracellular fluid (ECF) fluid outside the cells; includes in- travascular and interstitial fluids
  10. Water balance is regulated by thirst and ADH
  11. Isotonic when the concentration of two solu- tions is the same

11 /

  1. Potassium is the predominant ICF ion; it func- tions to regulate ICF osmolality, maintain the resting membrane po- tential, and deposit glycogen in liver and skeletal muscle cells
  2. Calcium a necessary ion in the structure of bones and teeth, in blood clotting, in hormone secretion and the function of cell receptors, and in membrane stability
  3. Phosphate acts as a buffer in acid-base regula- tion and provides energy for muscle contraction
  4. T/F: Parathyroid hormone (PTH), vi- tamin D, and calcitonin rigidly con- trol sodium and phosphate concen- trations. False: Parathyroid hormone (PTH), vitamin D, and calcitonin rigidly con- trol calcium and phosphate concen- trations.
  5. Magnesium a major intracellular cation and is principally regulated by PTH.
  6. hydrogen ion concentration The amount of hydrogen ions pre- sent in a solution
  7. acid-base balance equilibrium between acid and base concentrations in the body fluids
  8. Buffers mixtures that can react with acids or bases to keep the pH within a particular range

12 /

  1. T/F: Changes in the concentration of hydrogen in the blood will cause acid-base imbalances True
  2. Acidosis pH < 7.5, there is too much acid in the body fluids, Acidosis occurs

14 / False: Aging is theoretically distinct from disease and is thought to be the result of accumulated DNA dam- age, decreased proliferative capac- ity of stem cells, and accumulated metabolic damage.