PSYC 725
ARTICLE SUMMARY ASSIGNMENT
PSYC 725
In every article there are specific sections that one should be very knowledgeable of in order to
locate the appropriate information within a study. In this summary, this writer will give insight to the
various areas of each article to impose its information in brief form. The two articles that will be
discussed will be “A genome-wide association study of autism incorporating autism diagnostic interview-
revised, autism diagnostic observation schedule, and social responsiveness scale” by J. J. Connolly, J. T.
Glessner, & H. Hakonarson and “Head circumference and height in autism: A study by the collaborative
program of excellence in autism” by J. E. Lainhart, et. al.
J. J. Connolly, J. T. Glessner, & H. Hakonarson (2013) hypothesize whether specific
endophenotypes associated with ASDs show association with genes. If it can be proven that
endophenotypes associate with specific genes, the source of autism could be closer to being determined.
It can also clarify some of the impact that autism has both cognitively and behaviorally. J. E. Lainhart,
et. al. (2006) hypothesize that (1) the tendency toward increased head size in autism is a generalized
phenomenon afecting the population of individuals with idiopathic autism‐spectrum
disorders (ASD), (2) variation in standardized head circumference in autism is related to height, IQ,
SES, and parental head circumference but not age, similar to typically developing children, and (3)
macrocephaly identifies a unique subgroup of autism.
J. J. Connolly, J. T. Glessner, & H. Hakonarson (2013) referenced clinical data that matched the
genotype data for ADOS, ADI–R, and SRS yielded 2,165 individuals representing 926 unique families as
well as 553 females and 1,612 males; the 926 unique family members (probands) comprised 200 females
and 726 males. The ADI–R was used to classify DS symptoms of participants, family history reports were
taken, participants were classified according to how many members of their family had autism diagnosis,
