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Study Guide EXAM #1: Key Concepts in the Study of Life, Chemical Foundations of Life, Biological Macromolecules, and the Cell
1. Key Concepts in the Study of Life
Characteristics of Life
Cellular Organization: All living organisms are composed of cells, which can be unicellular (e.g., bacteria) or multicellular (e.g., plants,
animals).
Metabolism: The set of chemical reactions that occur within an organism, including:
Catabolism: Breakdown of molecules to release energy (e.g., digestion).
Anabolism: Building complex molecules from simpler ones, using energy (e.g., protein synthesis).
Homeostasis: The ability of organisms to maintain a stable internal environment (e.g., temperature, pH, water balance).
Growth and Development: Growth involves an increase in size or cell number, and development involves changes in the organism over time.
Reproduction: The ability to reproduce offspring (asexual or sexual).
Response to Stimuli: Organisms respond to environmental changes (e.g., light, temperature).
Adaptation: Changes in organisms over generations that make them better suited to their environment.
Heredity: Genetic information is passed from one generation to the next via DNA.
Levels of Biological Organization
Atoms Molecular: Molecules Cellular: Cells Tissues Organs Organ Systems Organisms Populations Communities
Ecosystems Biosphere
2. Chemical Foundations of Life
Atoms and Molecules
Atoms: The basic units of matter consisting of protons, neutrons, and electrons.
Elements: Substances composed of only one type of atom, like carbon (C), hydrogen (H), oxygen (O), nitrogen (N), phosphorus (P), and
sulfur (S), which are the key elements in biological molecules.
Molecules: Two or more atoms bonded together.
Types of Chemical Bonds
Covalent Bonds: Atoms share electrons to form a bond (e.g., HO). This bond is strong and common in biological molecules.
Ionic Bonds: One atom donates an electron to another, resulting in positively and negatively charged ions (e.g., NaCl).
Hydrogen Bonds: Weak bonds that form between the hydrogen atom of one molecule and the electronegative atom (e.g., oxygen) of another
molecule (important for water’s properties and DNA structure).
Water and Its Properties
Polar Molecule: Water has a partial positive charge on hydrogen atoms and a partial negative charge on oxygen atoms.
Solvent: Water dissolves many substances, making it the universal solvent.
Cohesion: Water molecules stick together due to hydrogen bonding (e.g., surface tension).
Adhesion: Water molecules cling to other substances (important for capillary action).
High Specific Heat: Water resists temperature change, helping organisms regulate body temperature.
Evaporative Cooling: Water absorbs heat when it evaporates, cooling the surface (important for thermoregulation).
pH and Buffers
pH: A measure of the acidity or alkalinity of a solution (0 to 14 scale; 7 is neutral, below 7 is acidic, above 7 is basic).
Acids: Donate H ions (e.g., HCl).
Bases: Accept H ions (e.g., NaOH).
Buffers: Help maintain a stable pH by absorbing or releasing H ions.
3. Biological Macromolecules
Carbohydrates
Monomers: Monosaccharides (simple sugars like glucose, fructose).
Polymers: Polysaccharides (long chains of monosaccharides). Examples:
Starch: Energy storage in plants.
Glycogen: Energy storage in animals.
Cellulose: Structural support in plant cell walls.
•Functions: Energy storage, quick energy source, structural components.
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Study Guide EXAM #1: Key Concepts in the Study of Life, Chemical Foundations of Life, Biological Macromolecules, and the Cell

  1. Key Concepts in the Study of Life

Characteristics of Life

  • Cellular Organization: All living organisms are composed of cells, which can be unicellular (e.g., bacteria) or multicellular (e.g., plants,

animals).

  • Metabolism: The set of chemical reactions that occur within an organism, including:
  • Catabolism: Breakdown of molecules to release energy (e.g., digestion).
  • Anabolism: Building complex molecules from simpler ones, using energy (e.g., protein synthesis).
  • Homeostasis: The ability of organisms to maintain a stable internal environment (e.g., temperature, pH, water balance).
  • Growth and Development: Growth involves an increase in size or cell number, and development involves changes in the organism over time.
  • Reproduction: The ability to reproduce offspring (asexual or sexual).
  • Response to Stimuli: Organisms respond to environmental changes (e.g., light, temperature).
  • Adaptation: Changes in organisms over generations that make them better suited to their environment.
  • Heredity: Genetic information is passed from one generation to the next via DNA.

Levels of Biological Organization

Atoms → Molecular: Molecules → Cellular: Cells → Tissues → Organs → Organ Systems → Organisms → Populations → Communities →

Ecosystems → Biosphere

  1. Chemical Foundations of Life

Atoms and Molecules

  • Atoms: The basic units of matter consisting of protons, neutrons, and electrons.
  • Elements: Substances composed of only one type of atom, like carbon (C), hydrogen (H), oxygen (O), nitrogen (N), phosphorus (P), and

sulfur (S), which are the key elements in biological molecules.

  • Molecules: Two or more atoms bonded together.

Types of Chemical Bonds

  • Covalent Bonds: Atoms share electrons to form a bond (e.g., H₂O). This bond is strong and common in biological molecules.
  • Ionic Bonds: One atom donates an electron to another, resulting in positively and negatively charged ions (e.g., NaCl).
  • Hydrogen Bonds: Weak bonds that form between the hydrogen atom of one molecule and the electronegative atom (e.g., oxygen) of another

molecule (important for water’s properties and DNA structure).

Water and Its Properties

  • Polar Molecule: Water has a partial positive charge on hydrogen atoms and a partial negative charge on oxygen atoms.
  • Solvent: Water dissolves many substances, making it the universal solvent.
  • Cohesion: Water molecules stick together due to hydrogen bonding (e.g., surface tension).
  • Adhesion: Water molecules cling to other substances (important for capillary action).
  • High Specific Heat: Water resists temperature change, helping organisms regulate body temperature.
  • Evaporative Cooling: Water absorbs heat when it evaporates, cooling the surface (important for thermoregulation).

pH and Buffers

  • pH: A measure of the acidity or alkalinity of a solution (0 to 14 scale; 7 is neutral, below 7 is acidic, above 7 is basic).
  • Acids: Donate H ⁺

ions (e.g., HCl).

  • Bases: Accept H⁺ ions (e.g., NaOH).
  • Buffers: Help maintain a stable pH by absorbing or releasing H⁺ ions.
  1. Biological Macromolecules

Carbohydrates

  • Monomers: Monosaccharides (simple sugars like glucose, fructose).
  • Polymers: Polysaccharides (long chains of monosaccharides). Examples:
  • Starch: Energy storage in plants.
  • Glycogen: Energy storage in animals.
  • Cellulose: Structural support in plant cell walls.
  • Functions: Energy storage, quick energy source, structural components.

Proteins

  • Monomers: Amino acids (20 different types).
  • Polymers: Polypeptides (chains of acids).
  • Functions:
    • Enzymatic Catalysis: Speed up chemical reactions (e.g., digestive enzymes).
    • Structural Support: Form cellular structures (e.g., collagen).
    • Transport: Carry molecules (e.g., hemoglobin).
    • Defense: Antibodies.
    • Signaling: Hormones and receptors.
  • Protein Structure:
    • Primary: Sequence of amino acids.
    • Secondary: Alpha-helices or beta-pleated sheets formed by hydrogen bonding.
    • Tertiary: Three-dimensional shape formed by interactions between R

Lipids

  • Monomers: Fatty acids and glycerol.
  • Polymers: Triglycerides (fats and oils), phospholipids, steroids (e.g., cholesterol).
  • Functions:
    • Energy Storage: Fats store more energy than carbohydrates.
    • Membrane Structure: Phospholipids form bilayers in cell membranes.
    • Insulation: Fats protect organs and help regulate body temperature.
    • Hormonal Signaling: Steroids like estrogen and testosterone.

Nucleic Acids

  • Monomers: Nucleotides (composed of a sugar, phosphate group, and nitrogenous base).
  • Polymers: DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).
  • Functions:
    • DNA: Stores genetic information in cells, passes genetic material from one generation to the next.
    • RNA: Involved in protein synthesis (mRNA, tRNA, rRNA).
    • ATP: The main energy carrier molecule in cells.
  1. Functional Groups

Functional groups are specific groups of atoms within molecules that have distinct chemical properties. These groups are important in the

structure and function of biological molecules.

  • Hydroxyl Group (-OH) : Found in alcohols (e.g., ethanol). Makes molecules polar and water-soluble.
  • Carbonyl Group (C=O) : Found in aldehydes and ketones. Important in sugars and metabolism.
  • Carboxyl Group (-COOH) : Found in acids (e.g., acetic acid). Acts as an acid by donating H⁺ ions.
  • Amino Group (-NH₂) : Found in amines and amino acids. Acts as a base by accepting H⁺ ions.
  • Sulfhydryl Group (-SH) : Found in thiols. Forms disulfide bridges, important in protein structure.
  • Phosphate Group (-PO₄²⁻) : Found in nucleotides and phospholipids. Involved in energy transfer (e.g., ATP) and DNA/RNA backbone.
  • Methyl Group (-CH₃) : A nonpolar group that affects the expression of genes and protein function.
  1. The Cell

Cell Theory

  • All living organisms are made of cells.
  • The cell is the basic unit of structure and function in living organisms.
  • All cells arise from pre-existing cells.

Prokaryotic vs. Eukaryotic Cells

  • Prokaryotic Cells: Simple, smaller cells (e.g., bacteria). They lack membrane-bound organelles and a nucleus. DNA is located in the

nucleoid region.

  • Eukaryotic Cells: Complex, larger cells (e.g., animals, plants, fungi). They have membrane-bound organelles and a true nucleus containing

DNA.

Cell Membrane Transport

  • Passive Transport: No energy required (e.g., diffusion, osmosis).
  • Active Transport: Requires energy (e.g., Na+/K+ pump, endocytosis, exocytosis).

Cell Division

  • Mitosis: Division of somatic cells producing two identical daughter cells.
  • Meiosis: Division of germ cells (gametes) producing four genetically diverse daughter cells.

Eukaryotic

Cell

Lysosome

nucleus

cytoskeleton

nucleolus

Mitochondria

cytoplasm

Smooter

Golgi

apparatus

Ribosomes

Rough

Endoplasmic

Reticulum

Nucleus : Contains the cell’s genetic material (DNA) organized into chromosomes. It controls the cell’s activities

through gene expression and acts as the center for DNA replication and RNA transcription. It is surrounded by the

nuclear envelope, which has pores for material exchange.

Nucleolus : Located within the nucleus, it is responsible for the synthesis of ribosomal RNA (rRNA) and the assembly

of ribosome subunits.

Plasma Membrane : A phospholipid bilayer that separates the interior of the cell from its external environment. It

regulates the movement of substances into and out of the cell, maintaining homeostasis.

Cytoplasm : A jelly-like substance that fills the cell and provides a medium for chemical reactions to take place. It

also supports the organelles.

Endoplasmic Reticulum (ER):

  • Rough ER: Studded with ribosomes; it synthesizes proteins and modifies them.
  • Smooth ER: Lacks ribosomes; it synthesizes lipids, detoxifies chemicals, and stores calcium ions.

Golgi Apparatus (Golgi Body) : Modifies, sorts, and packages proteins and lipids from the ER for transport to their

destination, either within the cell or to the plasma membrane for secretion.

Mitochondria : The powerhouse of the cell. They generate energy in the form of ATP through cellular respiration.

They also regulate cell metabolism and contain their own DNA.

Ribosomes : Responsible for protein synthesis. Ribosomes can be free in the cytoplasm or attached to the rough ER.

Lysosomes : Contain digestive enzymes that break down waste materials, foreign invaders, and cellular debris. They

also help in apoptosis (programmed cell death).

Peroxisomes : Involved in the breakdown of fatty acids and the detoxification of harmful substances like hydrogen

peroxide.

Cytoskeleton : Provides structural support, maintains cell shape, and facilitates cell movement. It is made up of

microtubules, microfilaments, and intermediate filaments.

Centrioles : Play a role in cell division by helping to organize the microtubules during mitosis and meiosis.

Vacuoles : Membrane-bound sacs that store water, nutrients, or waste products. In plant cells, a large central vacuole

helps maintain turgor pressure and stores substances.

Chloroplasts (in plant cells) : Contain chlorophyll and are responsible for photosynthesis, converting light energy

into chemical energy stored as glucose.

Cell Wall (in plant, fungi, and some protist cells) : Provides structural support and protection. In plants, it is made of

cellulose, while in fungi, it is made of chitin.

Plasmodesmata (in plant cells) : Channels that connect plant cells, allowing for the exchange of materials and

communication between cells.

Eukaryotic

cell

Organelle

functions

: