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Subject - pathophysiology. Topic - chronic renal failure. course - Pharm D, B pharma, M pharma, MBBS, all medical field. Notes made by ROHIT KUMAR SINGH.
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Chronic Renal Failure (CRF), also called Chronic Kidney Disease (CKD), is a long- term condition in which the kidneys slowly lose their ability to work properly over months or years. Kidneys normally remove waste products, maintain fluid balance, and control electrolytes. In CKD, these functions gradually decrease, leading to accumulation of toxins in the body (uremia). The disease is usually permanent and progressive. If not treated, it can lead to End-Stage Renal Disease (ESRD), where dialysis or kidney transplant becomes necessary. The most common causes are diabetes and high blood pressure.
Stage 1 (Kidney damage with normal function)
Step 1: Diagnose CKD (GFR + lab tests) Step 2: Treat underlying cause (diabetes, hypertension) Step 3: Start ACE inhibitors/ARBs Step 4: Manage complications: