miRNA
•>1000'human'miRNAs,'regulate'~60%'of'proteinS
coding'genes
•Control'gene'expression'postStranscripKonally'via'
either'repression'of'translaKon'or'mRNA'degradaKon
•Mainly'target'3’SUTR'of'RNA
51
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Control Gene - Human Resource - Lecture Slides, Slides of Human Resource Management
These are the fundamental aspects of following Lecture Slides : Control Gene, Coding, Genes, Gene, Expression, Repression, Translakon, Degradakon, Funckon, Complementarity
Typology: Slides
2012/2013
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miRNA
• >1000 human miRNAs, regulate ~60% of protein-‐
coding genes
• Control gene expression post-‐transcripKonally via
either repression of translaKon or mRNA degradaKon
• Mainly target 3’-‐UTR of RNA
miRNA
• miRNA funcKon in a complex, the miRNPs, composed
of Ago, Dicer, and TRBP
• Complementarity to 3’-‐UTR determines whether the
mRNA is degraded or translaKon is repressed
Viruses and cellular miRNAs
• miR-‐122 is a liver-‐specific miRNA required for HCV
replicaKon
• miRNAs target viral or cellular genes needed for viral
replicaKon
• miR-‐141 induced during enterovirus infecKon inhibits
translaKon of eIF4E mRNA
Virus-‐encoded miRNAs
• Viral miRs block apoptosis, facilitate immune escape,
prevent cell cycle arrest, promote latency