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CP Hematology Exam-MLT Questions and Answers
100% Correct| Latest Update 202 5 - 2026
The light-colored zone adjacent to the nucleus in a plasmacyte is the:
A. ribosome
B. chromatin
C. mitochondria
D. Golgi area - ✔✔D. Golgi area
The majority of the iron in an adult is found as a constituent of:
A. hemoglobin
B. hemosiderin
C. myoglobin
D. transferrin - ✔✔A. hemoglobin
The main function of the hexose monophosphate shunt in the erythrocyte is to:
A. reglate the level of 2,3-DPG
B. provide reduced glutathione to prevent oxidation of hemoglobin
C. prevent the reduction of heme iron
D. provide energy for membrane maintenance - ✔✔B. provide reduced gluta
In order for hemoglobin to combine reversibly with oxygen, the iron must be:
A. complexed with haptoglobin
B. freely circulating in the cytoplasm
C. attached to transferrin
D. in the ferrous state - ✔✔D. in the ferrous state
In which of the following disease states are teardrop cells and adnormal platelets most characteristically seen?
A. hemolytic anemia
B. multiple myeloma
C. G-6-PD deficiency
D. myeloid metaplasia - ✔✔D. myeloid metaplasia
In the normal adult, the spleen acts as a site for:
A. storage of red blood cells
B. production of red blood cells
C. synthesis of erythropoietin
D. removal of imperfect and aging cells - ✔✔D. removal of imperfect and aging cells
A. shorten the replication time of the granulocytes
B. stimulate RNA synthesis of erythroid cells
C. increase colony-stimulating factors produced by the B-lymphocytes
D. decrease the release of marrow reticulocytes - ✔✔B. stimulate RNA synthesis of erythroid cells
What cell shape is most commonly associated with an increase MCHC?
A. teardrop cells
B. target cells
C. spherocytes
D. sickle cells - ✔✔C. spherocytes
Which of the following characteristics are common to hereditary spherocytosis, hereditary elliptocytosis, hereditary stomatocytosis, and paroxysmal nocturnal hemoglobinuria?
A. autosomal dominant inheritance
B. red cell membrane defects
C. positive direct anti-globulin test
D. measured platelet count - ✔✔B. red cell membrane defects
Which of the following is most closely associated with iron deficiency anemia?
A. iron overload in tissue
B. target cells
C. basophilic stippling
D. chronic blood loss - ✔✔D. chronic blood loss
Evidence indicates that the generic defect in thalassemia usually results in?
A. the production of abnormal globin class
B. a quantitative deficiency in RNA resulting in decreased globin chain production
C. a structured change in the heme portion of the hemoglobin
D. an abnormality in the alpha- or beta-chain binding or affinity - ✔✔B. a quantitative deficiency in RNA resulting in decreased globin chain production
An enzyme deficiency assciated with moderate to sever hemolytic anemia after the patient is exposed to certain drugs and characteristized by red cell inclusions formed by denatured hemoglobin is:
A. lactate dehydrogenase deficiency
B. G-6-PD deficiency
C. pyruvate kinase deficiency
D. hexokinase deficiency - ✔✔B. G-6-PD deficiency
D. pancytopenia and microcytosis - ✔✔A. pancytopenia and macrocytosis
Laboratory tests performed on a patient indicate macrocytosis, anemia, leukopenia, and thrombocytopenia. Which of the following disorders is the patient most likely to have?
A. anemia of chronic disorder
B. vitamin B12 deficiency
C. iron deficiency
D. acute hemorrhage - ✔✔B. vitamin B12 deficiency
The characteristic morphological feature in folic acid deficiency is:
A. macrocytosis
B. target cells
C. basophilic stippling
D. rouleax formation - ✔✔A. macrocytosis
The most likely cause of the macrocytosis that often accompanies anemia of myelofibrosis is:
A. folic acid deficiency
B. increased reticulocyte count
C. inadequate B12 absorption
D. pyroxine deficiency - ✔✔A. folic acid deficiency
A characteristic morphologic feature in hemoglobin C disease is:
A. macrocytosis
B. spherocytosis
C. rouleax formation
D. target cells - ✔✔D. target cells
Thalassemias are characterized by:
A. structural abnormalities in the hemoglobin molecule
B. absence of iron in hemoglobin
C. decreased rate of heme synthesis
D. decreased rate of globin synthesis - ✔✔D. decreased rate of globin synthesis
Laboratory findings in hereditary spherocytosis do not include:
A. decreased osmotic fragility
B. increased autohemolysis corrected by glucose
C. reticulocytosis
D. shortened erythrocyte survival - ✔✔A. decreased osmotic fragility
Which of the following technical factors will cause a decreased erythrocyte sedimentation rate?
A. gross hemolysis
B. small fibrin clots in the sample
C. increased room temperature
D. tilting of the tube - ✔✔B. small fibrin clots in sample
Which of the RBC indices is a measure of the amount of hemoglobin in individual red blood cells?
A. MCHC
B. MCV
C. Hct
D. MCH - ✔✔D. MCH
The RDW-CV and RDW-SD performed by automated cells counters are calculations that provide:
A. an index of the distribution of RBC volumes
B. a calculated mean RBC hemoglobin concentration
C. a calculated mean cell hemoglobin
D. the mean RBC volume - ✔✔A. an index of the distribution of RBC volumes
The erythrocyte sedimentation rate (ESR) can be falsely elevated by:
A. tilting the tube
B. refrigerate blood
C. air bubbles in the column
D. specimen too old - ✔✔A. tilting the tube
Which of the following is the formula for absolute cell count?
A. number of cells counted/total count
B. total count/number of cells counted
C. 10 x total count
D. % of cells counted x total cell count - ✔✔D. % of cells counted x total cell count
The laboratory tests performed on a patient indicate macrocytosis, anemia , leukopenia, and thrombocytosis. Which of the following disorders is the patient most likely to have?
A. iron deficiency
B. hereditary spherocytosis
C. vitamin B12 deficiency
D. acute hemorrhage - ✔✔C. vitamin B12 deficiency
A. macrocytic, normochromic erythrocytes
B. microcytic, hypochromic erythrcytes
C. normocytic, hypochromic erythrocytes
D. normocytic, normochromic erythrocytes - ✔✔C, normocytic, hypochromic erythrocytes
Evidence of active red cell regeneration may be indicated on a blood smear by:
A. basophilic stippling, nucleated red blood cells and polychromasia
B. hypochromia, macrocytes, and nucleated red blood cellse
C. hypochromia, basophilic stippling, and nucleated red blood cellse
D. Howell-Jolly bodies, Cabot rings, and basophilic stippling - ✔✔A. basophilic stippling, nucleated red blood cells and polychromasia
The presence of excessive rouleax formation on a blood smear is often accompanied by an increased:
A. reticulocyte count
B. sedimentation rate
C. hematocrit
D. erythrocyte count - ✔✔B. sedimentation rate
The characteristic peripheral blood morphologic feature in multiple myeloma is:
A. cytotoxic T cells
B. rouleax formation
C. spherocytes
D. macrocytosis - ✔✔B. rouleax formation
In polycythemia vera, the homeoglobin, hematocrit, red blood cell count, and red cell mass are:
A. elevated
B. normal
C. decreased - ✔✔A. elevated
The M:E ratio in polycythemia vera is usually:
A. normal
B. high
C. low
D. variable - ✔✔A. normal
Many microspherocytes, schostocytes, and budding off of spherocytes can be seen on peripheral blood smears of patients with:
A. hereditary spherocytosis
B. disseminated intrvascular coagulation (DIC)
D. clumped platelets - ✔✔B. very high WBC count
The most appropriate screening test for detecting hemoglobin F is:
A. osmotic fragility
B. dithionite solubility
C. Kleihauer-Betke
D. heat instability test - ✔✔C. Kleihauer-Betke
The most approprite screening test for hemoglobin S is:
A. Kleihauer-Betke
B. dithionite solubility
C. osmotic fragility
D. sucrose hemolysis - ✔✔B. dithionite solubility
Hematology standards include:
A. stabilized red blood cell suspension
B. latex particles
C. stabilized avian red blood cells
D. certified cyanmethemoglobin solution - ✔✔D. certified cyanmethemoglobin solution
When using the turbidity (solubility) method for detecting the presence of hemoglobin 2, an incorrect interpretation may be made when there is a(n):
A. concentration of less than 7g/dL ( 70 g/L) hemoglobin
B. glucose concentration greater than 150 mg/dL (8.3 mmol/L)
C. blood specimen greater than 2 hours old
D. increased hemoglobin - ✔✔D. increased emoglobin
The laboratory findings on a patient are as follows:
MCV: 55 um^3 (55 fL)
MCHC: 25%
MCH: 17 pg
A stained blood film of this patient would most likely reveal a red cell picture that is:
A. microcytic, hypochromic
B. macrocytic, hypochromic
C. normocytic, normochromic
D. microcytic, normochromic - ✔✔A. microcytic, hypochromic
A patient has the following laboratory results:
RBC: 2.00 x 10^6/uL (2.00 x 10^12/L)
Hct: 24%
B. increased MCV and normal RBC
C. decreased MCV and increased MCHC
D. decreased MCV and RBC - ✔✔D. MCV and RBC
In polycythemia vera, leukocyte alkaline phosphatase activity is:
A. elevated
B. normal
C. decreased - ✔✔A. elevated
Which of the following is the formula for mean corpuscle hemoglobin (MCH)?
A. Hct/(RBC x 1000)
B. Hgb/Hct
C. RBC/Hct
D. (Hgb x 10)/RBC - ✔✔D. (Hgb x 10)/RBC
What is the MCH if the Hct is 20%, the RBC is 2.4 x 10^6/uL (2.4 x 10^12/L) and the Hgb is 5g/dL (50 g/L)?
A. 21 um^3 (21 fL)
B. 23 um^3 (23 fL)
C. 25 um^3 (25 fL)
D. 84 um^3 (83 fL) - ✔✔A. 21 um^3 (21 fL)
What is the MCH if the Hct is 20%, the RBC is 1.5 x 10^6/uL (1.5 x 10^12/L), and the Hgb is 6 g/dL (60 g/L)?
A. 28 um^3 (28 fL)
B. 30 um^3 (30 fL)
C. 40 um^3 (40 fL)
D. 75 um^3 (75 fL) - ✔✔C. 40 um^3 (40 fL)
Which of the following is the correct formula for MCHC?
A. (Hgb x 100)/Hct
B. Hgb/RBC
C. RBC/Hct
D. (Hct x 1000)/RBC - ✔✔A. (Hgb x 100)/Hct
What is the MCHC if the Hct is 20%, the RBC is 2.4 x 10^6/uL (2.4 x 10^12/L) and the Hgb is 5 g/dL (50 g/L)?
A. 21%
B. 25%
C. 30%
