Dermatology Revision Notes, Study Guides, Projects, Research of Clinical Medicine

This document provides a structured guide to basic dermatological principles, focusing on skin anatomy, lesion classification, and key inflammatory skin conditions like eczema. It includes definitions and diagnostic features of macules, papules, pustules, vesicles, fissures, ulcers, and more, with clear differentiation based on texture, size, and pigmentation. Detailed notes on atopic eczema cover pathophysiology (e.g., filaggrin mutation, IgE-mediated response), risk factors, typical presentations by age, and tiered treatment with emollients, topical corticosteroids, and calcineurin inhibitors. Also includes management for discoid eczema.

Typology: Study Guides, Projects, Research

2024/2025

Available from 08/07/2025

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Traumatic Conditions
Burns injury
In a burn, there is local response with progressive tissue loss and
release of inflammatory cytokines
– Loss of capillary membrane integrity leads to fluid leading into
interstitial space, leading to hypovolemic shock
– There is increased risk of bacterial infections (S. Aureus), acute
peptic stress ulcers and lung injury
&
Before treating the burn, it is essential to measure
the&extentand&depthof the burn
Extent –Measured by Wallace’s Rule of Nines, divided body into 11
sections each measuring 9% surface area
– Used to generate burn measurement quantified by the total body
surface area (TBSA)
&
Depth– This is measured by the depth it penetrates through the
dermis
– 1st degree –> this is confined to the epidermis and is likely to be red
and tender
– 2nd degree –>This is where the burn penetrates the dermis layer
giving blisters and reducing feeling
– 3rd degree –> This is where the burn penetrates the full thickness of
the skin. It will appear brown/black
&
Management– Perform first aid (Airway, breathing, circulation)
i) Immediate fluid resuscitation using Hartman’s solution if TBSA >15%
– Uses the Parkland formula:
– Total fluid in 24 hours = 4ml x total burn surface area (%) x body
weight (kg)
– 50% given in first 8 hours, and 50% given in next 16 hours
– Give fluids till urine output 0.5-1ml/kg/hr (insert urinary catheter)
&
ii) Maintenance fluids – After 24 hours, colloid infusion at 0.5ml x total
burn surface area (%) x body weight (kg)
– Crystalloid (dextrose-saline) at 1.5ml x total burn surface area (%) x
body weight (kg)
&
iii) Refer to hospital if: 2nd/3rd degree burn, deep dermal burns>5%
TBSA (adults), electrical/chemical burn
Pressure Sores
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Traumatic Conditions

Burns injury

In a burn, there is local response with progressive tissue loss and release of inflammatory cytokines

  • Loss of capillary membrane integrity leads to fluid leading into interstitial space, leading to hypovolemic shock
  • There is increased risk of bacterial infections (S. Aureus), acute peptic stress ulcers and lung injury Before treating the burn, it is essential to measure the extent and depth of the burn Extent – Measured by Wallace’s Rule of Nines, divided body into 11 sections each measuring 9% surface area
  • Used to generate burn measurement quantified by the total body surface area (TBSA) Depth – This is measured by the depth it penetrates through the dermis
  • 1st degree –> this is confined to the epidermis and is likely to be red and tender
  • 2nd degree –>This is where the burn penetrates the dermis layer giving blisters and reducing feeling
  • 3rd degree –> This is where the burn penetrates the full thickness of the skin. It will appear brown/black Management – Perform first aid (Airway, breathing, circulation) i) Immediate fluid resuscitation using Hartman’s solution if TBSA >15%
  • Uses the Parkland formula:
  • Total fluid in 24 hours = 4ml x total burn surface area (%) x body weight (kg)
  • 50% given in first 8 hours, and 50% given in next 16 hours
  • Give fluids till urine output 0.5-1ml/kg/hr (insert urinary catheter) ii) Maintenance fluids – After 24 hours, colloid infusion at 0.5ml x total burn surface area (%) x body weight (kg)
  • Crystalloid (dextrose-saline) at 1.5ml x total burn surface area (%) x body weight (kg) iii) Refer to hospital if: 2nd/3rd degree burn, deep dermal burns>5% TBSA (adults), electrical/chemical burn

Pressure Sores

These are wounds that develop when continuous pressure or friction damages the skin

  • Constant pressure reduces normal blood flow, so cells die, and skin breaks down
  • They develop in patients who are unable to move parts of their body Risk factors: Immobility (bed-ridden or after surgery), poorly nourished, incontinent Appearance – Painful ulcers over bony prominences, sacrum, hips, heels, elbows Management – Water low Score is used to screen for patients at risk of pressure sores
  • Keep the wound moisturized –> Avoid using soap and use hydrocolloid dressing
  • Turning the patient over and encouraging them to move

This is a benign proliferation of adipocytes, occurring in age group (more in adults). They are asymptomatic but they cause pressure on other structures Appearance

  • Smooth, mobile, non-tender lump, mostly subcutaneous
  • Usually found on the arms, back of neck, torso and the thighs Management
  • Most need no treatment, except surgical excision if symptomatic
  • If they start to change size, are painful or situated deeper in tissue, remove due to risk of becoming malignant (liposarcoma).

Dermis and Epidermal Tumours

Benign Lesions

Seborrheic keratosis

This is a benign squamous cell proliferation, common in elderly

  • Sudden onset of many lesions suggests GI carcinoma, known as the Leser-Trelat sign

Appearance

  • Raised brown/black plaques on extremities/face
  • Coin like, “stuck on” appearance that can be very variable Management Completely benign but can be removed if suspicion of cancer

Dermatofibroma

This is an overgrowth of fibrous tissue in the dermis

  • Made up of fibroblasts, it is thought to be a reactive process or a neoplasm
  • It is completely benign and does not turn into cancer Appearance
  • Single dermal firm nodule found usually on the legs and arms
  • Usually <1cm and do not cause symptoms (but can be painful/itchy)

Keratoacanthoma

This is a benign tumor (mostly) in sun-exposed skin

  • It grows rapidly at a site of minor injury and can be up to 2cm in diameter Appearance
  • Starts as a boil but then becomes dome-shaped with keratin filled crater
  • Cannot be clinically distinguished from more severe forms of skin cancer Management
  • Surgical excision as hard to exclude SCC

Bowen’s disease (Squamous cell carcinoma in situ)

This is an early superficial stage of squamous cell carcinoma.

  • Squamous cells proliferate through epidermis but do not invade dermis.
  • Often found in sun-exposed areas such as the legs/hands. Risk factors: UV radiation, arsenic, HPV infection and immune suppression Appearance
  • Irregular orange-red scaly patches several centimeters Management
  • Must be removed surgically or 5-flourouracil, but high recurrence rate

Appearance

  • Looks like a scaly, crusty ill defined nodule which may ulcerate
  • Can occur on the face, lips, ears and limbs Management
  • Surgical excision with larger margins for larger diameter lesions
  • Mohs micrographic surgery used in high-risk patients.

Basal Cell carcinoma (BCC)

This is a proliferation of epidermal keratinocytes

  • Most common cutaneous malignancy usually seen in elderly
  • Metastasis is very rare as it usually grows slowly and invades locally Risk factors: UV, sunlight, xeroderma pigmentosum, old age Appearance – Elevated skin colored papule with surface telangiectasia
  • Commonly scabs and bleeds and then reforms scab
  • Pearly appearance, usually seen over the head and neck Management – 1st line is surgical removal

Disorders of Melanocytes

These conditions are marked by an intrinsic problem with melanocytes, the pigment producing cells.

Vitiligo

This is an acquired autoimmune condition which leads to the destruction of melanocytes causing depigmentation of the skin (leukoderma).

  • Most frequent mutation is in BRAF which leads to uncontrolled cell division

Appearance – Starts as an unusual freckle/mole but then becomes

abnormal with ABCD :

  • A symmetry
  • B orders irregular
  • C olour not uniform
  • D iameter >6mm
  • Suspect melanoma if:
  • Change in size, shape, colour, or sensation
  • Diameter >6mm or if the lesion is oozing or bleeding Types – There are 4 main types of melanoma a) Superficial spreading – Most common (70%) seen in limbs and torso of young people b) Nodular – 2nd most common and most aggressive which looks more like a nodule which can bleed c) Lentigo maligna – A type of melanoma in-situ which progresses

slowly but can become invasive d) Acral lentiginous – Rare form with pigmentation under nails/palms/soles of black and Asian people Diagnosis – Skin biopsy and histology Treatment – Excision biopsy + sentinel lymph node mapping Prognosis

  • The Breslow Thickness (invasion depth of tumor) is single most important factor.
  • If <1mm, almost all patients survive 5-years
  • If >4mm, 50% less than half survive 5 years
  • Tumor usually metastasizes to the lung, other parts of skin, bone and brain

Melasma

This is a mask like hyperpigmentation of the cheeks, upper lip and forehead

  • Thought to be due to melanocyte dysfunction leading to more melanin production
  • It is associated with pregnancy and oral contraceptives Management – Hydroquinone (topical depigmenting agent)

Albinism

Genetic Skin Disorders

Neurofibromatosis Type 1 (NF1) (von Recklinghausen disease)

This is a complex multi-system disorder, caused by loss of protein Neurofibromin needed in many cells

  • An autosomal dominant condition which is caused by a mutation/deletion of NF-1 gene on Chromosome 17

This is an autosomal dominant condition which is due to a genetic mutation on Chromosome 22. Symptoms

  • Gives bilateral acoustic neuromas –> sensorineural hearing loss + tinnitus and vertigo
  • Tumours are benign but can cause problems due to compression and raised ICP
  • Also gives multiple intracranial tumours such as schwannomas and meningiomas Management
  • Hearing tests annually after puberty for affected families + MRI scan
  • Neurosurgery for acoustic neuromas –> can gives hearing loss and facial palsy

Tuberous Sclerosis

A rare neurocutaneous disorder that causes benign tumours to grow in the brain and other organs like heart, skin

  • Due to autosomal dominant mutation in TSC1 (chromosome 9) or TSC2 (Chr 16) leading to hamartoma formation Skin features:
  • Hypopigmented “ash-leaf spots” which fluoresce under UV light
  • Angiofibroma in butterfly pattern around nose (adenoma sebaceum)
  • Connective tissue naevus (Shagreen patch) – elevated patch of skin on back
  • Subungual fibroma (under nails) Other Organs:
  • Heart –> Rhabdomyomas (benign tumours of muscle) of the heart
  • Lung –> multiple lung cysts
  • Kidneys –> Polycystic kidney disease + benign tumours
  • Eye –> hamartoma formation on the retina giving visual disturbances
  • CNS –> epilepsy due to hamartoma formation in central nervous system Associations:
  • Associated with developmental delay