PHA 5127 Fall 2007
Case Study #1
#1) Patient H.G. was given 1000mg drug X as an i.v. bolus. Determined plasma
concentration-time profiles are listed in the table below.
time
(h) Plasma concentration
(mg/L)
0 50
1.5 32
4 15
7 6
10 2.5
15 0.5
a) Determine whether the drug follows a zero- or a first-order elimination process!
b) Calculate the elimination rate constant (ke)!
c) Calculate AUC0Æ∞!
d) Can you predict what the concentration of drug X after two half-lives will be?
#2) Which of the following statements best describes a zero or a first order process?
a) The same amount of drug is eliminated during a given time interval.
b) The same fraction of drug is eliminated during a given time interval.
c) Given a one-compartment body-model, a concentration vs. time profile after an
i.v. bolus shows a straight line on a linear scale.
d) Given a one-compartment body-model, a concentration vs. time profile after an
i.v. bolus shows a straight line on a semi-log scale.
