PHA 5127
Homework #1
(Total: 10 points)
#1) Calculate AUC0
Æ
∞ from the given concentration-time profile. (3 points)
Time (h) Plasma concentration (mg/L)
1 94.8
4 80.1
6 70.3
8 59.9
12 40.1
#2) Fractions and amounts of drugs eliminated through zero- and first-order kinetics
(2 points)
#2a) How do fraction and amount of a drug eliminated through first-order kinetics
change? Please, mark the right answer. (1 point)
o Fraction changes, amount stays constant
o Fraction stays constant, amount changes
o Fraction changes, amount changes
o Fraction stays constant, amount stays constant
#2b). How do fraction and amount of a drug eliminated through zero-order kinetics
change? Please, mark the right answer. (1 point)
o Fraction changes, amount stays constant
o Fraction stays constant, amount changes
o Fraction changes, amount changes
o Fraction stays constant, amount stays constant
#3) Please derive the half-life equation for a first-order elimination process. (3 points)
#4) What is the difference in distribution of drugs into organs such as the heart and the
lung compared to fat tissue and bone? Explain! (2 points)
1
