Epigenetic Small Molecules: Emerging Drugs for Disease Treatment, Slides of Biology

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epigenetic small molecules

In the field of epigenetics, changes in DNA methylation and histone

post-translational modification patterns are the focus of research. Many

proteins are involved in the process of DNA methylation and histone

modification, some of which participate in binding modified DNA or

histones, and others can catalyze or remove those specific chemical

groups. These epigenetic proteins have become emerging drug

development targets for many diseases. Current researches have

produced a large number of small-molecule drug candidates targeting

epigenetic key factors and chromatin remodeling factors, and have also

promoted the study of epigenetic modulators in diseases.

Creative BioMart has a series of small-molecule epigenetic modulators

(including activators, antagonists, and inhibitors), and these include

targets to DNA methyltransferases (DNMTs), DNA demethylases,

histone methyltransferases (HMTs), histone demethylases (HDMs),

histone acetyltransferases (HATs), histone deacetylases (HDACs),

histone phosphorylation-related enzymes and reader domain-

containing proteins. Because epigenetic regulation plays an important

role in the occurrence and development of diseases such as cancer,

these small-molecule epigenetic modulators are important tools for

researchers to perform epigenetic drug discovery projects.

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• Epigenetics Small Molecules - Methyltransferase Modulators & Inhibitors - Demethylase Modulators & Inhibitors - Histone Acetyltransferase (HAT) Modulators & Inhibitors