Gastrointestinal Pathophysiology (HST-121)
Laboratory Assignment #2
(Due Monday November 14
th
)
NAME:
Recommended reading:
1. Lecture notes on Gastroduodenal and Intestinal Pathophysiology
2. Small and Large Intestine in Robins Pathological Basis of Diseases, 6
th
ed., 1999, W. B. Saunders Co.,
pages 802-826.
Additional optional reading:
Chapters 3 and 5 in Gastroenterology, Saunders Text and Review Series, 1997, W. B. Saunders Co.
Decide if each of the following statements is true or false?
⎯
Zollinger-Ellison syndrome is characterized by hypertrophy of gastric foveolar cells due to
hypersecretion of gastrin.
⎯
H
2
-blockers decrease basal and stimulated acid secretion by binding histamine receptors on parietal
cells.
⎯
Glut-2 is a Na and glucose/galactose co-transporter at the apical brush border of absorptive intestinal
epithelial cells.
⎯
Atrophic gastritis results in loss of glandular epithelium in the gastric mucosa.
⎯
H. pylori infection is associated with gastric but not duodenal PUD.
⎯
Protein losing enteropathy is primarily due to biochemical defects that result in abnormal digestion and
absorption of proteins.
⎯
Chloride secretion by intestinal epithelial cells is driven by the active transport of chloride into the
epithelial cells by the basolateral Na/K/2Cl-ATPase.
⎯
Cholera and E. coli heat-labile toxins induce cAMP-mediated osmotic diarrhea by activation of
adenylyl cyclase.
⎯
COX-1 is constituitively expressed on all cell types, while COX-2 expression is limited in the absence
of inflammation.
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assignment 2
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