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Gastrointestinal Pathophysiology (HST-121)
Laboratory Assignment
(Due Monday November 28
th
NAME:
Recommended reading:
- Lecture notes on pancreatic physiology and pancreatitis
Additional optional reading: Pages 63-77 in Gastroenterology, Saunders Text and Review Series, 1997, W. B. Saunders Co.
Fill in the blanks:
Centroacinar and intralobular duct cells secrete _______________ and _______________.
Interlobular and main duct cells secrete _________________ and ________________.
Acetylcholine acts through _________________ as the second messenger and stimulates secretion by
the ________________ cells.
Secretin acts through _________________ as the second messenger and stimulates ductal
______________ secretion.
______________________ inhibits CCK and secretin release.
Pancreatic trypsinogen is converted to trypsin in the duodenum by the action of _________________.
____________________ and ____________________ are the two leading causes of acute pancreatitis.
Ranson's criteria for prognosis of acute pancreatitis at admission include:
- Age > _________ years
- _________ > 200 mg/dl
- AST > ___________ U/L
- WBC > ___________
- ________ > 350 IU/L
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Gastrointestinal Pathophysiology (HST-121)
Case 1:
The microscopic slide GI-14 is from an emergency operation on a 52-year-old alcoholic man who presented with a precipitous drop in hematocrit, shock, and markedly elevated amylase and lipase. What is the most appropriate description for this slide?
⎯ Acute pancreatitis
⎯ Chronic pancreatitis
⎯ Acute hemorrhagic pancreatitis superimposed on chronic pancreatitis
⎯ Pancreatic adenocarcinoma
Case 2:
The microscopic slide GI-15 is from an elective operation (to relieve back pain) on a 48-year-old alcoholic man who has had bouts of steatorrhea and back pain for many years. What is the most appropriate description for this slide?
⎯ Acute pancreatitis
⎯ Chronic pancreatitis
⎯ Acute hemorrhagic pancreatitis superimposed on chronic pancreatitis
⎯ Pancreatic adenocarcinoma
Case 3:
The microscopic slide GI-16 is from a pancreatic resection in a 54-year-old man with weight loss and abdominal pain. What is the most appropriate description for this slide?
⎯ Acute pancreatitis
⎯ Chronic pancreatitis
⎯ Acute hemorrhagic pancreatitis superimposed on chronic pancreatitis
⎯ Pancreatic adenocarcinoma
Case 4:
The microscopic slide GI-17 is from a cholecystectomy specimen in a 46-year-old woman with chronic right upper quadrant pain. Are there any Rochitansky-Aschoff sinuses in this gallbladder?
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