MODULE 5: REGULATION OF GENE
EXPRESSION VIA CELL SURFACE
RECEPTORS
1. What are the two major signal transduction pathways? What is the
property of ligands that accounts for the two major classifications of signal
transduction?
2. Describe the role of the proto-oncogene Ras in signal transduction
3. Describe the regulation of gene expression by cytokines such as
interferon gamma
4. Distinguish amongst autocrine, paracrine and endocrine signaling
5. The reaction catalyzed by adenylate cyclase involves:
a) conversion of ATP to cyclic AMP
b) conversion of cyclic AMP to AMP
c) conversion of cyclic AMP to ATP
d) conversion of AMP to cyclic AMP
6. How is inositol tripohosphate (IP3) synthesized inside the cells?
7. When a G-protein interacts with a receptor, the G protein is split into:
a) a γ-subunit and an α, β-dimer
b) a β-subunit and an α, γ-dimer
c) an α-subunit and a β, γ-dimer
d) its component protein subunits
8. Calmodulin is a protein which:
a) binds calcium ions and activates protein kinases.
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