HDAC and SIRT Inhibitor Screening: A Comprehensive Approach at Creative BioMart, Slides of Biology

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HDAC Inhibitor Screening

Histone deacetylases (HDACs) are enzymes removing acetyl groups from lysine

residues on histone tails, restoring the positive charge of the histone tail lysine residue.

HDACs are involved in important biological procedures, including cell differentiation,

proliferation, apoptosis, and senescence. Site-specific histone deacetylation could

result in a more tightly compacted, heterochromatin conformation, thus repressing

eukaryotic gene transcription. Class I, II, and IV belong to the classic HDAC enzymes,

whereas class III comprises sirtuin (SIRT) enzymes that require the cofactor NAD+ for

their activity. Aberrant HDAC enzyme expression is observed in various diseases and

therefore HDAC has been proved to be novel epigenetic targets for the treatment of

cancer. It has become one of the most important research fields to find small

molecules that function as HDAC enzyme inhibitors with promising anti-tumor

efficacy in vitro and in vivo , especially during the coming area of epigenetics. Quite a

few HDAC inhibitors have come into the market as anti-cancer drugs, and dozens more

are in the process of clinical trials.

Benefits of Histone Deacetylase/SIRT Screening Services at Creative BioMart

Screen inhibitors or targets with our wide range panels of HDACs and SIRTs

• IC

50

(half maximal inhibitory concentration) determination and single point

concentration determination

Get project guidance in a time-efficient manner

Available for profiling and low cost high-throughput screening

High sensitivity and reproducibility

Fast turnaround time

Creative BioMart offers unbeatable services in HDAC screening with the most competitive price and

is dedicating to identifying your inhibitors or activators against HDACs targets with the great chance

to success. Our highly professional team in state-of-the-art labs will customize the most adequate

assay campaign to ensure your project advances quickly and promise a successful progression in

epigenetic drug research with high quality, reliability and efficiency. If you have any special

requirements in HDACs or SIRTs assay services, please feel free to contact us.

Reference

1. Wu, D. F.; et al. Screening of selective histone deacetylase inhibitors by proteochemometric

modeling. BMC Bioinformatics. 2012, 13: e212.