Liver dysfunction ............., Assignments of Pharmacy

Download Liver dysfunction ............. and more Assignments Pharmacy in PDF only on Docsity! CHEMISTRY OF NATURAL PRODUCT (MPC 104T) ASSIGNMENT TOPIC – Liver Dysfunction – Phyllanthus Niruri Session – 2020-21 SUBMITTED TO - SUBMITTED BY- Prof. N.S. Hari Narayana Moorthy RAM RUDRA SAHU (Dept of pharmacy) M.Pharmacy 1st sem. (Pharma. Chem.)  Natural Products as Medicine -  LIVER DYSFUNCTION - ¢ The plant is useful for treating hepatotoxicity, hepatitis B, hyperglycemia and viral and bacterial diseases. * P. niruri has been used in Ayurvedic medicine for over 2000 years and has a wide number of traditional uses for jaundice, gonorrhoea, frequent menstruation and diabetes. = Phytochemistry - * Many of the active constituents to which the biological activity of P. niruri has been attributed Chemical class Phytochemicals present Rependucinic acid, geraniin, corilagin  Pharmacological effects and responsible constituents phytochemicals Tannins Saponins Alkaloids Lignans Flavonoids Terpenes Coumarins Effects Reverse transcriptase inhibitor, antihypertensive, antifungal Anti fungal, cardiovascular Antispasmodic, antimalarial, antimicrobial, Hepetoprotective, antigenotoxic, anti HIV, antiinflammatory Blood vessel strengthener, anti-oxidant, anticancer, anti- inflammatory, antiseptic, anti leishmanial, antidiarrhoeal, diuretic, Anticarcinogenic, antioxident, antimicrobial, anti- inflammatory cancer chemopreventive, vasorelaxent,  Mainly Lignans are responsible for Hepetoprotective and anti-hepatitis activities. Constituents contribute at most to its hepetoprotective activity are phyllenthin and hypophyllanthin. Both have exhibited a significant protection against CCl, and galactosamine-induced elevation in liver transferase enzymes levels and significantly increased protein levels. They have also reported to inactivate hepatitis B, both in-vitro and in-vivo. Phyllanthin possesses anti-viral activity against HIV by inhibiting reverse transcriptase. Phyltetralin, nirtetralin and niranthin exhibited anti- inflammatory activity by inhibiting carragecnan- induced pawoedema and neutrophil influx Structures of lignans: cc H3CO ~o¢ HCO I “OCH; 3 OCH3 meee _OCH3 ey OCH; I 4 I ~OCH; ~~ ~ocn; OCH; OCH; Phyllanthin Hypophyllanthin