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This document from psyc 3507 alcohol, drugs & behavior course provides an overview of major concepts related to tranquilizers, sedative-hypnotics, and their mechanisms of action. Topics include the primary uses, ideal characteristics, general mechanism of action, differences in pharmacokinetic properties, abuse potential, and withdrawal effects of barbiturates and benzodiazepines. Additionally, the document covers alternative drugs like buspirone, ghb, and rohypnol.
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Psyc 3507 Alcohol, Drugs & Behavior Terms and Concepts Chapter 7
familiar with any relationships between terms and concepts as you will be expected to apply your knowledge on exams. Be sure to ask questions if there is something that you don’t understand. What are tranquilizers primarily used for? What are sedative-hypnotics primarily used for? What would be ideal characteristics for drugs used as tranquilizers or anxiolytics? What would be ideal characteristics for drugs used as sedative hypnotics? What is common to both tranquilizers/anxiolytics and sedative hypnotics, in terms of their general mechanism of action? How are barbiturates and benzodiazepines alike and different in how they produce their actions? What is the end result of their action? What are three ways that barbiturates (and benzodiazepines) differ in their pharmacokinetic properties? Which tranquilizers/anxiolytics and sedative hypnotics are most likely to be abused? Why? When should different routes of administration be considered for barbiturates and benzodiazepines? Why are there differences in the speed of absorption of barbiturates and benzodiazepines? What major factor determines the distribution and excretion of barbiturates and benzodiazepines? When considering the “maximum effect” of a given dose of barbiturate or benzodiazepine, why does this effect generally have a fast onset of action and short duration of action? As barbiturates and benzodiazepines get redistributed in body fat, what is the effect on blood levels of the drug? As barbiturates and benzodiazepines in the blood are metabolized, what is the effect on blood levels of the drug? Why? What two things ultimately determine the duration of action of barbiturates and benzodiazepines? What are some of the factors that account for why benzodiazepines are only effective in relieving anxiety in a portion of persons suffering from anxiety? How are barbiturates and benzodiazepines similar to alcohol in terms of characteristics of their actions and the effects they produce? To which effects of benzodiazepines is tolerance likely to develop quickly? Slowly? Not at all? When does physical dependence usually occur when taking benzodiazepines? What major factor influences the severity of withdrawal from benzodiazepines? Why is the severity generally less than that seen with most sedative hypnotics?
Psyc 3507 Alcohol, Drugs & Behavior Terms and Concepts Chapter 7 When are noticeable withdrawal symptoms from benzodiazepines most likely to be seen? (Hint: answer is not when all drug is removed from blood stream) What are some of the liabilities associated with use of barbiturates? Why is it so dangerous to take tranquilizers/anxiolytics or barbiturates with alcohol? What type of tolerance is most often associated with barbiturates/benzodiazepines? Why is buspirone a good alternative to benzodiazepines? What is GHB? What is it used as? What are its biphasic effects? How is it similar and dissimilar to alcohol? What is Rohypnol? What is its relationship to benzodiazepines? What are the two major patterns of benzodiazepine use? Terms Tranquilizer Sedative Hypnotic GABA GHB Rohypnol Barbiturate Benzodiazepine Iatrogenic Use Street Use *If given examples, be able to recognize that a drug ending with “ital” is a barbiturate and those ending with “pam” are benzodiazepines