NUTR 4320 – FINAL QUESTIONS WITH VERIFIED
ACCURATE ANSWERS
Expression of genes in different microbiomes of the body - Answers - There are distinct
genes expressed in different microbiomes
Gene count in obesity - Answers - Obese individuals have lower gene counts compared
to non-obese
What do LCG individuals exhibit? - Answers - More adiposity
Insulin resistance
Dyslipidemia
Increase inflammatory mediators
What does inflammation in colon lead to? - Answers - Tissue damage
Loss of epi. integrity
Polyps
FODMAP for IBD and IBS - Answers - FODMAP is an effective tool for IBS BUT only
short term usage for IBD
Issue with FODMAP - Answers - No good SCFA production
Why would fibre/SCFA be good in IBS or IBD? - Answers - Increase remission time
Decrease inflammation
Butyrate effect in colonic homeostasis - Answers - Treatment for colitis
- increase colonic IL-10 secretion
Proliferation and apoptosis
Decrease pH
- inhibit growth of pathogenic
Stimulate mucin and anti-microbial peptides (REG3y)
inhibit TNF-a
Why is butyrate production low in IBD patients? - Answers - Decrease abundance of
butyrate producers (e.g. Prevotella and Roseburia species)
IBD dysbiosis - Answers - Decrease
- abundance
- diversity
- function and gene count
What do sulfate-reducing bacteria (SRB) produce? - Answers - H2S
