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Immunology Key Concepts: Complement Pathways and B Cell Activation, Exams of Advanced Education

University of OxfordAdvanced Education

A concise overview of key concepts in immunology, focusing on complement pathways and b cell activation. It includes questions and answers related to tfh cell function, complement receptor roles (cr1, cr2), and the effects of various cytokines (il-4, il-5, ifn-y, tgf-b) on immunoglobulin production. Additionally, it covers the differences between naive b cells and plasma cells, th2 cell functions, and the sequential steps of complement pathways (alternative, lectin, classical). This material is useful for students studying immunology or related fields, offering a quick reference for understanding complex immune mechanisms and their components. It also includes information about the role of th1 and th2 cells in immune responses, detailing their cytokine production and effects on macrophages and b cells.

Typology: Exams

2024/2025

Available from 11/18/2025

Toperthetop
Toperthetop 🇬🇧

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PCB 3233 chapter 9 and 10
Phase 5 - correct answer ✔✔finding infection
Phase 6 - correct answer ✔✔Attacking Infection
TFH cell cytokines - correct answer ✔✔IL-16
TGF-beta
IL-23
TFH cell transcription factor - correct answer ✔✔Bcl6
TFH cell characteristic cytokines - correct answer ✔✔IL-21
TFH cell function - correct answer ✔✔activate B cells maturation of antibody
response
CR1 is on - correct answer ✔✔B cells
C3b is on - correct answer ✔✔the pathogen
Cr1 binds to - correct answer ✔✔C3b: facilitates its cleavage by factor I to iC3b and
C3d
CR2 is on - correct answer ✔✔B cell (also)
C3d is on - correct answer ✔✔the pathogen (also)
Cr2 binds to - correct answer ✔✔C3d: signal is sent through CD19
pf3
pf4

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PCB 3233 chapter 9 and 10

Phase 5 - correct answer ✔✔finding infection Phase 6 - correct answer ✔✔Attacking Infection TFH cell cytokines - correct answer ✔✔IL- TGF-beta IL- TFH cell transcription factor - correct answer ✔✔Bcl TFH cell characteristic cytokines - correct answer ✔✔IL- TFH cell function - correct answer ✔✔activate B cells maturation of antibody response CR1 is on - correct answer ✔✔B cells C3b is on - correct answer ✔✔the pathogen Cr1 binds to - correct answer ✔✔C3b: facilitates its cleavage by factor I to iC3b and C3d CR2 is on - correct answer ✔✔B cell (also) C3d is on - correct answer ✔✔the pathogen (also) Cr2 binds to - correct answer ✔✔C3d: signal is sent through CD

IL-4 induces - correct answer ✔✔IgG1 and IgE IL-4 inhibits - correct answer ✔✔IgM IgG IgG2a IL-5 augments production of - correct answer ✔✔IgA IFN-y induces - correct answer ✔✔IgG3 and IgG2a IFN-y inhibits - correct answer ✔✔IgM IgG IgE TGF-B induces - correct answer ✔✔IgG2b and IgA TGF-B inhibits - correct answer ✔✔IgM and IgG Naive B cell - correct answer ✔✔Surface Ig- Yes Surface MHC class 2- Yes High rate Ig secretion- No Growth- Yes Somatic hyper-mutation- Yes Isotype switch- Yes Plasma Cell - correct answer ✔✔Surface Ig- No Surface MHC class 2- No High rate Ig secretion- Yes Growth- No

Classical pathway C5 convertase - correct answer ✔✔C4b2a3b (also) Alternative pathway C3 convertase - correct answer ✔✔C3bBb Alternative pathway C5 convertase - correct answer ✔✔C3B2Bb soluble C3 convertase of alternative pathway - correct answer ✔✔iC3Bb