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Pharm Comprehensive Study Guide Review Updates
1.
volume
of
distribution:
amount of drug in body/plasma drug
concentration
2.
Lipid
solubility
+
partition
coefficient:
higher
lipid
solubility
=
higher
partition
coefficient
3.Alkalkine Drugs : examples and pH + pKa:
LA, opioids
-
pH > pkA = unionized
-
pH = pKa = unionized and ionized are equal
-
pH
<
pKa
=
ionized
4.Acidic Drugs: examples and pH + pKa:
barbituates
-
pH > pkA = ionized
-
pH = pKa = unionized and ionized are equal
-
pH
<
pKa
=
unionized
5.Normal creatine clearance males and females: males 97-137 mL/min
females 88-
128mL/min
6.
creatinine
clearance
formula:
((140-age)
x
weight
(kg))
/
(72
x
SCr)
multiply
by
.85
if
female
7.Therapeutic Index:
LD50/ED50
LD50-
dose
required
to
produce
death
in
50%
of
patient
ED50-
dose
required
to
produce
specific
response
in
50%
of
patient
want
this
to
be
large
as
possible
8.
TC:
1 TC - 63%
2
TC
-
86%
3
TC
-
95%
4
TC
-
98%
