Pharmaceutical Analysis Test 1, Exercises of Pharmaceutical Analysis

Pharmaceutical Analysis Test 1

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Pharmaceutical Analysis 24/09/2014
Test 1: Name & student number: _____________________________________
Duration: 1 hour, Total marks: 54
Answer ALL questions
1. Which of the following is the strongest Bronsted base?
A. Ammonia
B. Hydrofluoride
C. Water
D. methane
2. Which quantity is directly measured in titration?
A. Mass
B. Volume
C. Concentration
D. Viscosity
3. The end point is changed by which of the following?
A. By adding reagent
B. By adding the catalyst
C. By adding water
D. By increasing the temperature
4. Which of the following combination forms buffer solution?
A. NaI, HI
B. KBr, HBr
C. CsF, HF
D. RbCl, HCl
5. Buffers are prepared by_______.
A. weak acid and weak base
B. strong acid and strong base
C. salt and acid
D. weak acid and its conjugate base
6. Which of the following is the most appropriate indicator for the titration of acetic acid with
the NaOH?
A. Indigo caramine
B. Phenolphthalein
C. Methyl red
D. Bromocresol green
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Pharmaceutical Analysis 24/09/

Test 1 : Name & student number: _____________________________________

Duration: 1 hour, Total marks: 54

Answer ALL questions

  1. Which of the following is the strongest Bronsted base? A. Ammonia B. Hydrofluoride C. Water D. methane
  2. Which quantity is directly measured in titration? A. Mass B. Volume C. Concentration D. Viscosity
  3. The end point is changed by which of the following? A. By adding reagent B. By adding the catalyst C. By adding water D. By increasing the temperature
  4. Which of the following combination forms buffer solution? A. NaI, HI B. KBr, HBr C. CsF, HF D. RbCl, HCl
  5. Buffers are prepared by_______. A. weak acid and weak base B. strong acid and strong base C. salt and acid D. weak acid and its conjugate base
  6. Which of the following is the most appropriate indicator for the titration of acetic acid with the NaOH? A. Indigo caramine B. Phenolphthalein C. Methyl red D. Bromocresol green
  1. Which of the following acts as acid buffer? A. HCl and NaOH B. KOH and KBr C. NH3 and NH4Cl D. CH3COOH and NH3COO
  2. Assay of secobarbitol is done by which of the following titration? A. Acid-base titrimetry B. Non-aqueous titrimetry C. Complexometry D. Argentometry
  3. Which of the following is not true? A. Lewis acids contains hydrogen ion B. All Lewis acids are Bronsted acids C. Lewis acids are electron acceptors D. Water acts as acid and base according to Bronsted-Lowry theory
  4. When the concentration of weak acid and its conjugate base are equal_______. A. buffer capacity is decreased B. equilibrium point is not obtained C. hydrogen ion concentration and the acid constant are equal D. buffer capacity is unchanged
  5. Codeine phosphate is assayed by______. A. sodium methoxide B. perchloric acid C. HCl D. tetra butyl ammonium hydroxide
  6. Erythromycin is assayed by ______. A. conductometry B. polarography C. acid-base titrimetry D. non-aqueous titrimetry
  7. Which of the following drug is not assayed by the non-aqueous titrimetry? A. Sulfadrug B. Isoprenaline C. Lignocaine D. Paracetamol
  8. Nor triptyline is assayed by______. A. perchloric acid B. sodium methoxide C. tetrabutyl ammonium hydroxide D. HCl
  9. Which of the following is an example of amphiprotic solvent? A. Water B. HCl C. HF D. H2SO
  1. Which of the following is the protophillic solvent? A. Benzene B. HCl C. Water D. Ammonia
  2. Which of the following drug is not assayed by the non-aqueous titrimetry? A. Thiamine B. Ethambutol C. Salbutamol D. Ascorbic acid
  3. Which of the following is a strong oxidizing agent? A. Sn+ B. Pb+ C. Cu+ D. Ni+
  4. When a substance is oxidized the oxidation number_________. A. increases with electron loss B. decreases with electrons loss C. increase with electrons gain D. decreases with electrons gain
  5. Which of the following acts as self-indicator? A. Methylene blue B. Phenathrolene blue C. Safferine D. Potassium permanganate
  6. 2,6 – dichloro indophenol is used as redox titrant in the assay of________. A. thiamine B. ribofavin C. cyanacobalamin D. ascorbic acid
  7. Which of the following has the bromine oxidation number as +1? A. HBr B. BR C. HBrO D. HBrO
  8. Reducing agent undergoes_________. A. oxidation with loss of electrons B. oxidation with gain of electrons C. Reduction with loss of electrons D. reduction with gain of electrons
  9. What is the oxidation number of nitrous acid? A. + B. + C. + D. +
  1. Which of the following is the strong reducing agent? A. Hg B. Sn C. Zn D. Ag
  2. Isoniazid assay is carried by which of the following method? A. Acid-base titrimetry B. Non-aqueous titrimetry C. Redox titrimetry D. Complexometry
  3. The oxidizing agent used in the analysis of metallic peroxides________. A. ceric ammonium sulphate B. potassium permanganate C. iodine solution D. bromine solution
  4. Diazotization is mainly used for the determination of which of the following? A. Alcohols B. Carboxylic acids C. Phenols D. Amines
  5. Which of the following is the indicator used in the diazotization titrations? A. Methyl orange B. Methyl red C. Phenolphthalein D. Starch mucilage
  6. The temperature maintained for the diazotization titration is_______. A. 10 – 25 °C B. 0 – 10 °C C. 5 – 15 °C D. 15 – 30 °C
  7. The diazotization titration does not depend upon_______. A. rate of titration B. temperature C. concentration D. order of addition of the reactants
  8. Diazotization titration is used for which of the following drug determination? A. Salbutamol B. Ethambutol C. Secobarbitol D. Chloropheneramine
  9. Which of the following drug cannot be assayed by the diazotization titration? A. Amphetamine B. Procaine C. Ephedrine D. Ethambutol
  1. By which of the following complexometric method, calcium gluconate is titrated? A. Direct titration B. Indirect titration C. Replacement titration D. Back titration
  2. Masking is not affected by which of the following? A. Complexation B. Precipitation C. pH D. Temperature
  3. Complexometry titration end point is affected by the___________. A. nature of metal ion B. concentration of metal ion C. ability of the ligand D. all of these

Pharmaceutical Analysis: Test 1 24/09/

Name & student number: _____________________________________

ANSWER SHEET

27 TOTAL